Showing 101–125 of 200 documents
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Seyedehsara Motamen
…enging and requires early diagnosis, effective chemotherapy regimens, and drug-resistance screening. Therefore, development of shorter and simpler drug regimens that are safe, suitable for joint tuberculosis/HIV treatment, and well tolerated is essential. Fragment-based drug disc…
Mark Hatherill, MD, FCPaed
…ccinated with routine BCG at birth. However, TB vaccination regimens that depend on newborn BCG will remain unsafe for HIV infected infants. Infants of HIV infected mothers, who constituted 29% of babies born in South Africa in 2009, would benefit from a new TB vaccination strate…
Sahar Gazeran, Mohammad Emami, Fariba Zemorshidi
BACKGROUND AND OBJECTIVE: Mycobacterium tuberculosis affects millions of people in the world and Iran is one of the endemic areas. This disease has a wide range of manifestations, which is pulmonary in 80 – 85% of cases and extrapulmonary in 15 – 20% of cases. The most notable ex…
Y Hafeeza, M Rishitha, Naga Yeseswini S, Venu Babu A, Sumavi Sekhar J, et al.
… and older age group, both males and females, on category I regimens. Patients with comorbidities like HIV, diabetes, and social habits like smoking were included. Record based TB diagnosed data (August 2019 to January 2020) are taken and asses their treatment outcome after 6mont…
Eun Hwa Lee, BumSik Chin, Young Keun Kim, Jin Sae Yoo, Young-Hwa Choi, et al.
…atus, CD4+ T cell counts, viral load, past and current cART regimens, isolated NTM species, results of antimicrobial susceptibility tests, treatment regimens, and outcomes were collected by reviewing medical records. A total of 34 cases of NTM in PLWHA were included. Pulmonary an…
Syahrul Ramadan Rambe, Reza Mahruzza Putra, Heru Rahmadhany
Tuberculous Spondylitisis a secondary infectious disease of the spine that often occurs, from some literature it is found that almost half of all scletal tuberculosis sufferers are Tuberculous Spondylitis. Until now, the management of Tuberculous Spondylitis is still controversia…
Tomohiko Ai, Li Jiang, Q B Liu, Yulong Bai, Yang Yang, et al.
The efficacy of HRZEL regimen is similar to conventional HRZE regimen in children with TBM, but with higher adverse effect. Prudentially evaluating the pros and cons of linezolid in the usage of drug-susceptible TB and carefully monitoring of linezolid associated adverse effects …
Fadia Bejja, Badreddine Dahou, Fatiha Aboulhoda, A. Mokhtari, Abdelmajid Soulaymani
…ounted for 46%. There were two main stages to the treatment regimens recommended by the WHO. During the initial phase, 96% of patients received a two-month quadritherapy (for new cases), 3% received a three-month regimen (for retreatment cases), and 2% received a three-drug thera…
Tejal Pareshkumar Patel, Stanley Mwenda Aruyar, Paul Bundi Karau
Abdominal tuberculosis (TB), an extrapulmonary manifestation of TB, can present with nonspecific symptoms that may resemble an acute surgical abdomen or abdominal malignancy. Peritoneal tuberculosis/TB peritonitis, typically manifests with abdominal pain, abdominal distension (po…
Claudia L. Do Vale, Saraladevi Naicker, Christopher K. Lippincott
IntroductionAcute kidney injury (AKI) in hospitalized individuals is associated with increased length of hospitalization and mortality.1Vachiat A.I. Musenge E. Wadee S. Naicker S. Renal failure in HIV-positive patients—a South African experience.Clin Kidney J. 2013; 6: 584-594htt…
Nargiza Parpieva, Askar Anvarovich Adilkhodzhaev, Zarifa Abdiraubovna Muminova
The incidence of tuberculosis caused by Mycobacterium bovis, not only the pulmonary form, but also the form developing in the extrapulmonary organs, is also increasing from year to year. Despite the large number of EPTB, TBPLN occupies a leading place among diseases of this type …
Tshavhungwe, Mvuwo phophi
…ease. There has been little adjustment to the standard drug regimens over several decades, but there remain many unknowns about their effectiveness, especially because penetration across the blood-brain barrier (BBB) has been difficult to study. Rifampicin (RIF) is a leading drug…
Ashraf ALakkad, Mahmoud Sami, Jehad Saleh Abdalla, Nasifa Batool Tahir
This case study revolves around a 38-year-old male patient who arrived at the Emergency department complaining of decreased levels of consciousness, agitation, and disorientation. The case follows his admittance to the ICU, while a team of doctors worked on finding a possible dia…
Universidad Cuauhtémoc Aguascalientes. Aguascalientes, Mexico., Juan Fausto Martínez González, Ana Cristina González, Universidad Popular Autónoma del Estado de Puebla. Puebla, Mexico., Manuel Servı́n, et al.
…nal Ziehl-Neelsen staining. Treatment requires standard ATT regimens (e.g., 2HRZE/4HR), though drug-resistant cases necessitate tailored regimens. Conclusion: Heightened clinical suspicion, aided by advanced diagnostics, is critical for timely CTB management. Interdisciplinary co…
Badr Aljarallah
Objective: Intestinal tuberculosis (ITB) is an important form of extrapulmonary TB that often mimics other gastrointestinal diseases, making early diagnosis and management challenging. This study aimed to assess the clinical features, diagnostic approaches and treatment response …
Alsehali A, Alrajih H, Al-Jahdali H, Al-Safi E, Layqah L, et al.
Introduction Tuberculosis (TB) is a significant contributor to morbidity and mortality. With a progressively aging population, TB is increasingly encountered in older adults. Understanding the clinical presentation and optimal treatment strategies for TB in this population is ess…
Wirdah A, Andayani YD, Syahrir M, Djamaludin N, Murti K, et al.
…ed a complete response, especially with chemotherapy R-CHOP regimens.
Saylor D
… associated with high mortality even with current treatment regimens, although novel, promising strategies for treatment are under investigation, including a combination of IV isoniazid and ethambutol and high-dose rifampicin. Summary TB can affect the nervous system in various w…
Supot Nimanong
Tuberculosis (TB) remains a significant public health concern in Thailand and globally, especially in tropical regions, with pulmonary TB being predominant. Besides affecting the lungs, TB can also impact extrapulmonary organs. Standard TB treatment involves a combination of drug…
Webster Chewe, Abidan Chansa, Patrick Lungu, Namakando Liusha
Extrapulmonary drug resistant tuberculosis (DRTB) is a rare manifestation of disseminated tuberculosis which carries high mortality more so if the central nervous system (CNS) is affected. This paper reviews two cases of extrapulmonary DR-TB, involving two males both aged 32 year…
Maria Vitória Melo Almeida, Gustavo Alessandro Boritiza da Silva, YGOR MAGALHÃES MIRANDA, Rossela Damasceno Caldeira
Tuberculous Meningoencephalitis (TBME) is a severe manifestation of extrapulmonary tuberculosis, frequently associated with delayed diagnosis due to the nonspecific nature of early symptoms. This case report describes a 46-year-old man residing in Uruará, western Pará, previously…
Chepsy C Philip, Bobby Abraham, Sreehari Rajasekharakurup, Aakash Chozakade, Paul Mathi Vathana Karunagaran, et al.
Background Patients with acute promyelocytic leukemia (APML) undergoing induction therapy are severely immunocompromised and prone to opportunistic infections. Tuberculosis (TB), though less commonly considered, can complicate the clinical course, particularly in endemic regions.…
M Ghufran, H Arshad, P A Mir, S Sahni
Abstract Introduction Tuberculosis (TB) remains a major global health concern. Central nervous system (CNS) involvement, particularly Tuberculous Meningoencephalitis (TBM), is the most severe form, carrying high morbidity and mortality. We present a rare and aggressive case of a …
Lere P. Oluwadare, Pauline K. Akowundu, Joshua O. Awofeso, Oladotun V. Olalusi, Oyindamola O. Aderinto, et al.
The occurrence of tuberculous meningitis in children is relatively rare, but it is associated with higher rates of mortality and severe morbidity. Confirmation of diagnosis is often difficult, and other infectious aetiologies such as bacterial, viral and fungal causes must be rul…
Venugopalan Y. Vishnu, PulikottilWilson Vinny
Tuberculous meningitis (TBM) is a medical emergency. It is the most devastating manifestation of tuberculosis (TB). The outcome depends on early diagnosis and appropriate treatment. Empirical antituberculous therapy should be started if clinical suspicion is high. All patients sh…