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Gupta A, Juneja S, Babawale V, Rustam Majidovich N, Ndjeka N, et al.
…e rollout of new WHO-recommended shorter all-oral treatment regimens for drug-resistant TB (DR-TB), which remains a public-health crisis. The all-oral, 6-month BPaL/M regimen comprises 3-4 drugs: pretomanid used in combination with bedaquiline and linezolid, with or without moxif…
Khan PY, Franke MF, Hewison C, Seung KJ, Huerga H, et al.
…le agents, in use for decades, and endorsed all-oral longer regimens. However, questions remain about the role of the injectable agent, particularly in the context of regimens using new and repurposed drugs. We compared the effectiveness of an injectable-containing regimen to tha…
Nguyen TMP, Nguyen BH, Hoang TTT, Nguyen HA, Vu DH, et al.
…on (WHO) recently recommended standardized all-oral shorter regimens for rifampicin resistant Tuberculosis (RR-TB). For highly resistant Tuberculosis patients such as pre-XDR-TB: RR-TB plus additional resistance to fluoroquinolones (FQ), the 6-9-months bedaquiline (bedaquiline)-b…
Malaisamy Muniyandi, Balaji Ramraj, Sathishkumar Vadamalai, Sahil Abdul Salam, Bella Devaleenal, et al.
**BACKGROUND:** Short-course regimens are currently explored to improve multidrug-resistant tuberculosis effects, reduce costs, as well as enhance patient adherence. Currently, we are determining the most cost-effective shorter regimen out of seven short-course regimens (6-9 …
Muniyandi M, Ramesh PM, Wells WA, Alavadi U, Sahu S, et al.
Objective To measure the economic impacts of the longer pre-XDR-TB treatment regimen and the shorter BEAT-TB India regimen. Methods In the current study, the economic impacts of the current 18-month pre-XDR-TB treatment regimen and the 6-9 month BEAT-TB regimen were evaluated usi…
Joseph M. Cicchese
… antibiotic treatment. Importantly, we find that changes to regimens provide greater improvements in granuloma sterilization times for these individuals. We also present a new pharmacodynamic model that incorporates the synergistic and antagonistic interactions associated with co…
Norbert Ndjeka, Rubeshan Perumal, Kamila Romanowski, Hlengani Mathema, Lateef Babatunde Amusa, et al.
**BACKGROUND:** Shorter all-oral regimens for the treatment of multidrug-resistant tuberculosis or rifampicin-resistant tuberculosis (MDR/RR-TB) have improved efficacy, but their performance under programmatic conditions remains insufficiently characterized. **METHODS:** We retr…
Wenhong Zhang, PHD
…l to evaluate the efficacy and safety of seven 9-month oral regimens compared to a 9-month standard of care (SOC) regimen in RR-TB participants susceptible to fluoroquinolones, and a bedaquiline-containing 9-month oral regimen compared to a 20-month conventional regimen in RR-TB …
Vijay Kumar, G S Sri Bharathi, Mohit Bhatia, Sankha Shubhra Chakrabarti, Upinder Kaur, et al.
…nalyze therapeutic outcomes with bedaquiline-based all-oral regimens for drug-resistant tuberculosis. A prospective observational study was conducted from August 2022 to March 2024 and patients of drug-resistant tuberculosis on all-oral regimens were enrolled. Among 100 patients …
Beijing Chest Hospital
…dard of care in China has historically involved 18-20 month regimens, the World Health Organization (WHO) has recently endorsed shorter, all-oral regimens. The BLMZ regimen, composed of Bedaquiline (B), Linezolid (L), Moxifloxacin (M), and Pyrazinamide (Z), demonstrated high effi…
J. A. M. Raaijmakers, Mike Marvin Ruth, Jodie A. Schildkraut, Erik van den Hombergh, Rob E. Aarnoutse, et al.
…ls infected with M. avium ATCC 700898 were exposed to these regimens for 21 d. PK profiles were determined at d 0 and d 21. The pharmacodynamic effect was measured by determining bacterial densities at d 0, 3, 7, 14 and 21 for intra- and extracellular fractions. Emergence of macr…
Ilangovan Ilavarasan, Vidhyanathan Ariharanathan, Chandrasekaran Sabitha Devi
…CI). Conclusion: The weekly HP regimen is superior to other regimens in reducing the incidence of TB. Additionally, the duration of the HP regimen is shorter compared to the commonly advised nine-month Isoniazid regimen. Compared with the daily dosage of Isoniazid, the weekly HP …
В. П. Гусева, Irina Vasilyeva, V. V. Testov
…dities. Therefore, developing alternative shortened therapy regimens with a favourable safety profile and proven efficacy remains an urgent task. Objective To compare the effectiveness of treatment of pulmonary TB with preserved susceptibility of M. tuberculosis to isoniazid, rif…
J van Ingen, F -Q ter Bruggen, A Lemson, W Hoefsloot
…cure in MAC-PD patients treated with clofazimine-containing regimens at a Dutch tertiary care center. Methods Single-centre retrospective cohort study of adults with macrolide-susceptible MAC-PD who initiated treatment with clofazimine as part of either a standard ethambutol-macr…
Yilin Zhang, Yang Li, Yan Ren, Ting Li, Yajiao Xing, et al.
…great threat to global health. Increasing evidence of novel regimens in trial settings has risen, but the combinations of oral shorter regimens have not been optimised. An evaluation of the efficacy and safety of short-term regimens utilizing various drug combinations is essentia…
Thi Mai Phuong Nguyen, Van Luong Dinh, Binh Hoa Nguyen, Thi Thanh Thuy Hoang, Viet Nhung Nguyen, et al.
…in-resistant TB (RR-TB) burden country. Different new RR-TB regimens were recommended in recent years. Locally-generated evidence about nationwide implementation of different RR-TB regimens is essential to inform national treatment guidelines. **METHODS:** A retrospective cohort…
Yilin Zhang, Yang Li, Yuanyuan Chen, Cui Cai, Hengzhong Yi, et al.
…IVES:** Effective rifampicin-resistant tuberculosis (RR-TB) regimens often include multiple QT-prolonging drugs, necessitating evaluation across different combinations. **METHODS:** Using pooled electrocardiogram data from two trials, three QT-prolonging shorter regimens for RR-…
Hasan T, Medcalf E, Nyang'wa BT, Egizi E, Berry C, et al.
…cal considerations in shifting to shorter tuberculosis (TB) regimens. Novel 6-month oral regimens that include bedaquiline (B), pretomanid (Pa), and linezolid (L), with or without a fourth drug, have been shown to be as or more effective than the established longer regimens for t…
Y. I. Feshchenko, N.А. Lytvynenko, L.M. Protsyk, M.V. Pohrebna, Yu.О. Senko
BACKGROUND. Six-month short-term treatment regimens for drug-resistant tuberculosis (DR-TB) are more effective and better tolerated compared to longer regimens. There is a need to develop a clear algorithm for their prescription. OBJECTIVE. To develop a clinical algorithm for sel…
Y. I. Feshchenko, N.А. Lytvynenko, L.M. Protsyk, M.V. Pohrebna, Yu.О. Senko
BACKGROUND. Six-month short-term treatment regimens for drug-resistant tuberculosis (DR-TB) are more effective and better tolerated compared to longer regimens. There is a need to develop a clear algorithm for their prescription. OBJECTIVE. To develop a clinical algorithm for sel…
Xueyi Chen, Oscar J Nino-Meza, Mona O. Sarhan, Bhavatharini Arun, Byeonghoon Jeon, et al.
…dicted tissue exposures which were used to design optimized regimens (Fig.1).Figure 1.Study design. Dynamic positron emission tomography (PET) was performed using radioanalogs of antibiotics (18F-pretomanid, 18F-sutezolid, 18F-linezolid and 76Br-bedaquiline) active against MDR st…
Shabadi N, Prashanth Kumar NK, Prakash B, Kulkarni P, Narayana Murthy MR
Introduction In the context of changing over from an intermittent treatment regimen to a daily regimen, it becomes crucial to understand the impact of a daily regimen on the treatment process and outcome. It enables health professionals to strengthen strategies, to enhance the qu…
Rashmi Ratnam, Parul Jain, Ram Awadh Singh Kushwaha, Amita Jain, Urmila Singh, et al.
…the World Health Organization (WHO) recommends two all-oral regimens for rifampicin-resistant (RR), multidrug-resistant (MDR), and extensively drug-resistant (XDR) TB: a longer M/XDR-TB regimen (18–20 months) and a shorter bedaquiline-containing MDR/RR-TB regimen (9–11 months). T…
Ionescu AM, Mpobela Agnarson A, Kambili C, Metz L, Kfoury J, et al.
…ared the cost-effectiveness of bedaquiline (BDQ) containing regimens with injectable containing regimens (short-course regimen [SCR] and long-course regiman [LCR]) in India, Russia, and South Africa. Methods The analysis evaluated the direct costs of DR-TB treatment which include…
Xinxin Zeng, Hao Xu, Aole Li, Juanjuan Liu, Yuhang Wu, et al.
…for childhood tuberculosis (TB), evaluation of TB treatment regimens for children in real-world settings in China remained limited, particularly regarding treatment duration, utilization of second-line anti-TB drugs (SLDs), and adverse events. This study aimed to describe the tre…