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Spinal tuberculosis in pediatric patients is frequently associated with multiple vertebral lesions and could be complicated by kyphosis. The diagnosis should be confirmed by culturing or molecular–genetic study of the pathological tissues that are harvested from the zone of bone …
…ground The WHO currently estimates that at least a third of pediatric and adolescent tuberculosis cases go untreated or incompletely treated each year. Many cases are detected but lost to follow-up due to underreporting to national or private surveillance systems. Methods We cond…
Muljadi R, Koesbandono, Octavius GS
Introduction Despite medical advancement, pediatric pulmonary tuberculosis (PTB) still has high morbidity and mortality, due to challenging detection in clinical practice. Ultrasound has been touted as the next best diagnostic tool but currently, this claim is unfounded. Therefor…
Taye K, Tolesa N, Tadewos A, Ketema W
…ckground Because of the pauci bacillary nature of childhood tuberculosis and the difficulties in obtaining proper sputum samples from young children, diagnosing childhood tuberculosis (TB) is difficult. Childhood TB needs early identification and care since it advances swiftly to…
Zainab Farooq, Hamza Sajid, Noor Un Nisa Irshad, Sakan Binte Imran
To the Editor, Pediatric TB is a significant global public health issue, with accurate diagnosis being a primary barrier to finding and treating afflicted children. According to WHO Global Tuberculosis Report 2024, an estimated 10.8 million people were diagnosed with TB worldwide…
Matthew Willis, Joelle Van de Wetering, Heynes Brown, Ewelina Julia Barnowska, Sophie Cw Stuetzle, et al.
**BACKGROUND:** Pediatric tuberculosis (TB) is a significant public health concern in India, contributing to 28% of the global pediatric TB burden. Despite its impact on child health, strategies to control TB have inadequately addressed pediatric cases, resulting in suboptimal ma…
Çakır E, Özdemir A, Daşkaya H, Umutoğlu T, Yüksel M
…e, gastric aspirate and bronchoalveolar lavage fluid in the diagnosis of childhood tuberculosis. Turk J Pediatr 2018; 60: 10-13. Pulmonary tuberculosis (TB) is an important cause of morbidity and mortality especially in developing countries. A definitive microbiologic confirmatio…
Shu‐Han Yu
As a new immunoassay, T-SPOT.TB has been widely used in the diagnosis of tuberculosis in children.A large number of clinical trials show that it has better sensitivity and specificity simultaneously, compared with other diagnostic methods for tuberculosis in children.This article…
M.D. Zvereva, Sunita Kanash, S.I. Petrova, В. А. Евсеев, Elena Malyarova, et al.
Diagnosis of tuberculosis in children is challenging because of variable clinical symptoms and no specific signs. We report a case of tuberculous osteomyelitis of the ribs, which demonstrates difficulties associated with the diagnosis of generalized tuberculosis in an 8-year-old …
Suba Guruprasad, Mukesh Sanklecha, Rama Yelikar
To study the usefulness of Xpert TB/Rif in diagnosis of childhood tuberculosis in India. Prospective study was including children from 1 month to 18 years of age with clinical suspicion of tuberculosis. All cases were classified as pulmonary and extra pulmonary tuberculosis based…
A Mosses, D Philbert, F Ngadaya, D Solomon, F Msafiri, et al.
Abstract Rationale Tuberculosis (TB) is a significant public health problem in sub-Saharan Africa, affecting individuals of all ages, including children. Tanzania, one of the countries with a high TB burden, faces persistent challenges in the timely diagnosis and treatment of ped…
Dhaked S, Sharma N, Chopra KK, Khanna A, Kumar R
…ovides the extent of patient and health system delays among pediatric tuberculosis (TB) patients. Objectives The study attempted to understand the treatment seeking pathways of pediatric TB patients under revised national tuberculosis control program (RNTCP). Study design and set…
AW Mesman, María José Morán Soto, Julia Coit, Róger Calderón, Juan Aliaga, et al.
Abstract Background Rapid and accurate diagnosis of childhood tuberculosis (TB) is challenging because children are often unable to produce the sputum sample required for conventional tests. Stool is an alternative sample type that is easy to collect from children, and studies in…
The COVID-19 pandemic has affected the diagnosis and treatment of pediatric tuberculosis (TB), which can pose a public health burden if not properly treated. This study aims to find out the risk factors for pediatric TB. The design of this study was cross-sectional, using TB surv…
NanoPin Technologies, Inc.
…stigate the accuracy of the NanoDetect-TB kit in diagnosing tuberculosis (TB) using frozen serum and plasma samples collected from individuals suspected to have TB disease. The main question\[s\] it aims to answer are: * How does this investigational device compare to the gold …
Basile FW, Nabeta P, Ruhwald M, Song R
The current diagnostic abilities for the detection of pediatric tuberculosis are suboptimal. Multiple factors contribute to the under-diagnosis of intrathoracic tuberculosis in children, namely the absence of pathognomonic features of the disease, low bacillary loads in respirato…
Gunawan H, Lamsu G, Achdiat PA, Suwarsa O, Hindritiani R
Multifocal tuberculosis (TB) is rare. The risk of occurrence of multifocal TB is increasing in immunocompromised patients. Cutaneous entanglement in multifocal TB occurs more infrequently, and its association with multifocal TB is scarcely reported. The aim of this case report wa…
Yuqing Chen, Hui Tang, Jieyuan Zheng, Qing Yang, Dongsheng Han
Tuberculosis (TB) remains a leading global infectious killer, yet traditional diagnostic methods are inadequate. Acid-fast staining suffers from low sensitivity, and mycobacterial culture requires prolonged incubation because of the slow growth of. PCR-based molecular assays allo…
Andreia Leite, Pollyanna Mafra Soares, Jêniffer Costa Dos Santos, Carla Nunes
Abstract Background Delays in diagnosing tuberculosis lead to longer infectious periods, posing a challenge in tuberculosis control. This is particularly relevant in high incidence areas (critical). Thus, the objectives of this work were to characterize tuberculosis diagnosis del…
Joelma Clotilde Costa Da Silva, Emília Marcelina Dos Santos, Dionisio Mendes, Raquel Duarte
<b>Introduction:</b> Delay in tuberculosis diagnosis implies a delay in its treatment and perpetuation of the transmission chain. This delay may be due to the patient, but it may also be due to the health system. <b>Objectives:</b> This study aimed to identify factors associated …
Damla Sel Coban, Hıncal Özbakır, Berna Avci Yavuz, Berna Kahraman Çetin, Özlem Erdoğan, et al.
To the Editors: Tuberculosis (TB) remains a significant public health concern in children, particularly in endemic regions. However, diagnosis can be challenging due to other respiratory infections that present with similar clinical and radiological features. Here, we report the …
М. С. Опанасенко, O.V. Tereshkovich, S. М. Shalahai, L. І. Levanda, T.V. Kirillova
Pediatric surgeons often to have different indications for the diagnosis and treatment of pathology of the thoracic cavity. Often, only invasive techniques, such as a biopsy, can help diagnose and determine further treatment. One of the reasons for performing thoracic operations …
Sun L, Qi X, Liu F, Wu X, Yin Q, et al.
Objectives Xpert Mycobacterium tuberculosis and rifampicin (MTB/RIF) Ultra assay has increasingly been used in adult tuberculosis diagnosis, but data relating to its diagnostic accuracy in children are lacking. Because a qualified sputum specimen is difficult to obtain in childre…
Peter J Kitonsa, Devan Jaganath
**INTRODUCTION:** Pediatric tuberculosis (TB), especially among children co-infected with HIV, remains a significant global health challenge. Traditional sputum-based diagnostics are less effective in this population due to difficulties in sample collection and paucibacillary dis…
The Lancet Microbe
When approximately 40% of people who develop tuberculosis (4·2 million of an estimated 10·6 million people, in 2021, according to WHO) are not diagnosed, how can the widespread use of sputum smear microscopy for initial diagnosis—a method developed over a century ago—still be jus…