Showing 101–125 of 200 documents
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Suman Saurabh, Pankaj Bhardwaj
The WHO consolidated guidelines covering the treatment of drug-resistant tuberculosis has been released on June 15, 2020.[1] Its release was much anticipated since it was announced in a rapid communication issued in December 2019. The 2020 guidelines[1] are in continuation to the…
Dan Qiu, JianHong Ma, ZhiFang Liu, XiangXing Zeng
…ntified as a high-burden country. Data on the prevalence of drug resistance is crucial for informing the selection of appropriate pharmacological interventions for the treatment of drug-resistant tuberculosis (DR-TB).To evaluate the prevalence and drug resistance patterns among p…
Colman RE, Seifert M, De la Rossa A, Georghiou SB, Hoogland C, et al.
Background Drug-resistant tuberculosis remains a major obstacle in ending the global tuberculosis epidemic. Deployment of molecular tools for comprehensive drug resistance profiling is imperative for successful detection and characterisation of tuberculosis drug resistance. We ai…
Yuanyuan Yu, Jie Cao, Hongqiu Pan, Hui Zhong, Xiaocui Wu, et al.
Bedaquiline (BDQ) has gradually become a core drug in drug-resistant tuberculosis (DR-TB) treatment, and the additional benefits of prolonging BDQ use remain unclear. Patients with DR-TB who received a BDQ-containing regimen from three Chinese clinical centers between 1 March 201…
Sakshita Agnihotri, Kuldeep Yadav
Objective: Resistance against Mycobacterium tuberculosis (MTB) is important in the sense that it has an implication in the control of tuberculosis. The terms used to describe resistance to antituberculosis drugs are resistance among new cases (or primary resistance) and resistanc…
Kazemian H, Heidari H, Heidari H, Kardan-Yamchi J, Ghafourian S, et al.
…ificant global public health threat. Besides extensive multidrug resistance, MTB possesses several properties for long-term viability in the host as well as stress adaptation and resistance in harsh conditions. The role of toxin-antitoxin (TA) systems in disseminating and maintai…
Min Gao, Tianchi Yang, G L Li, R Chen, Hung-Chi Liu, et al.
The results showed the main mutation types of resistance-related genes of MDR strains to many commonly used anti-tuberculosis drugs in China based on whole-genome sequencing, providing a basis for the development of sensitive and specific rapid molecular detection methods. At the…
Getachew Seid, Ayinalem Alemu, Getu Diriba, Betselot Zerihun, Gemechu Tadesse, et al.
…hallenge. Different reports were made on the concordance of drug-resistance profiles between the household contact and the purported index case. This study investigated the drug-resistance pattern concordance of the index-household contact pair in central Ethiopia. **METHOD:** A…
Dong Y, Ou X, Zhao B, Wang Y, Liu Y, et al.
The diagnosis of drug-resistant tuberculosis (TB) by molecular testing of Mycobacterium tuberculosis drug resistance genes is becoming increasingly common clinically. However, M. bovis , as an uncommon pathogen of human TB, may interfere with the test results. A comprehensive und…
Song QS, Zheng CJ, Wang KP, Huang XL, Tartakovsky M, et al.
…terature described radiological feature differences between drug-sensitive pulmonary tuberculosis (DS-PTB) and multidrug-resistant (MDR)-PTB were confounded by that MDR-PTB cases tend to have a longer history. Using history length matched DS-PTB and MDR-PTB cases from a well-defi…
Suranga Manilgama
Multi-drug resistant tuberculosis (MDR-TB), resistant to rifampicin and isoniazid, is more common in individuals previously treated for tuberculosis. The main cause of MDR-TB is transmission rather than de novo resistance during treatment. TB strains lacking catalase are typicall…
Arti D. Shah1 , Anchal Jain2 , Apoorva3 , Kusum V. Shah4 , Yash Rana5 , Saket kumar6
Drug resistant tuberculosis is a major public health concern in many countries including India, Isoniazidresistance (INH) accounts for 7.2 % of new cases globally.1In our case series 3 patients had INH monoresistance out of which 2 patients had no previous history anti tuberculos…
T C, L N, Vo N, L N, Tg T, et al.
Background The increasing prevalence and incidence of Multi Drug Resistant Tuberculosis (MDR-TB) is as a result of the defaulting of treatment by patients. Worldwide, several factors that contribute to patients defaulting to tuberculosis treatment protocol have been identified. T…
Gutiérrez-Aroca JB, Ruiz P, Vaquero M, Causse M, Casal M
Multidrug-resistant tuberculosis (MDR-TB) is a cause of increasing concern. This study investigated first-line anti-TB drug resistance in Mycobacterium tuberculosis strains submitted to the Tuberculosis Reference Center in Córdoba (Spain) between 2001 and 2015. A total of 1,207 c…
Lee T, Lee SJ, Jeon D, Lee HY, Kim HJ, et al.
Background Drug-resistance surveillance (DRS) data provide key information for building an effective treatment regimen in patients with multidrug-resistant tuberculosis (MDR-TB). This study was conducted to investigate the patterns and trends of additional drug resistance in MDR-…
Muhammad Sani Aliyu, Issa Garba, M. B. Tijjani, Mhi Doko, Mukhtar, G. L., et al.
This study characterized multi-drug resistant M. tuberculosis phenotypically by LJ-proportion method and genotypically by GenoType MTBDRplus LPA. Out of the forty M. tuberculosis isolates tested, two (5.0%) were found to be multi-drug resistant by the LJ proportion method, and on…
Kassa GM, Merid MW, Muluneh AG
Background Rifampicin and/or multidrug-resistant tuberculosis (RR/MDR-TB) remains an uncontrolled public health emergency that has been synergized by the recently increased person-to-person transmission in the community as primary RR/MDR-TB, which is defined as RR/MDR-TB in new T…
Rida Masood, Iyad Naeem Muhammad, Tuba Siddiqui, Madiha Mushtaque, Asma Irshad
…ort 2018, Pakistan is amongst the 30 countries high TB with drug-resistant Mycobacterium tuberculosis particularly MDR (multi-drug resistant strains). A retrospective study had been designed using DR-TB patients' records from January 2013 to the December 2017 year from a public s…
Wan-mei Song, Jing-yue Liu, Qi Fu, Tingting Xu, Shi-jin Li, et al.
Abstract Background: Finding out more predictors of drug-resistant tuberculosis (DR-TB) helps to facilitate TB prevention and control. Previous study had revealed that tobacco smoking and alcohol drinking might be a risk factor for developing drug-resistant tuberculosis. However,…
Melat Hatiya, Yared Merid, Addis Mola, Fanuel Belayneh, Musa Mohammed Ali
… of TB and TB/HIV co-infection. The emergence and spread of drug-resistant TB present significant challenges to TB care and control efforts, particularly multi-drug-resistant TB, which poses a serious public health issue in low-income countries such as Ethiopia. This study aimed …
Farhat M, Cox H, Ghanem M, Denkinger CM, Rodrigues C, et al.
Drug-resistant tuberculosis (TB) is estimated to cause 13% of all antimicrobial resistance-attributable deaths worldwide and is driven by both ongoing resistance acquisition and person-to-person transmission. Poor outcomes are exacerbated by late diagnosis and inadequate access t…
Parikshana Mathur, Pinky Choudhary, Rajkuberan Chandrasekaran, Ragini Singh, Hemant Kumar Daima
…nt even after the global initiatives and emergence of multi-drug resistance (MDR) strains have made the situation complicated. Herein, the exploitation of the same medications for several decades, ineffective drug administration, and insufficient patient follow-up are some of the…
Kassa GM, Merid MW, Muluneh AG
…l goshuatalay12@gmail.comBackground: Rifampicin and/or multidrug-resistant tuberculosis (RR/MDR-TB) remains an uncontrolled public health emergency that has been synergized by the recently increased person-to-person transmission in the community as primary RR/MDR-TB, which is def…
de Lourdes do Carmo Guimarães Diniz J, von Groll A, Unis G, Dalla-Costa ER, Rosa Rossetti ML, et al.
Treatment of drug-resistant tuberculosis requires extended use of more toxic and less effective drugs and may result in retreatment cases due to failure, abandonment or disease recurrence. It is therefore important to understand the evolutionary process of drug resistance in Myco…
C L Nagaraja, B L Shashibhushan, Mohammad Asif, PH Manjunath, Chandrasekhar Sagar
AIMS AND OBJECTIVES: To study the pattern of drug-resistance and treatment outcomes among patients with confirmed multidrug-resistant pulmonary tuberculosis (MDR-PTB). METHODS: A prospective study was conducted at Rajiv Gandhi Institute of Chest Diseases, Bengaluru, Karnataka, In…