Showing 101–125 of 200 documents
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Madhvi A, Mishra H, Leisching GR, Mahlobo PZ, Baker B
…l uptake and intracellular growth over time of a pathogenic drug-resistant and drug-susceptible M.tb strains (R179 and H37Rv) through colony forming units (CFUs). Both strains depicted similar uptake and intracellular growth in hMDMs and THP-1 macrophages over time (R179, p = 0.9…
Muhammed S Bah, Kyaw Ko Ko Htet, Gregory P Bisson, Celso Khosa, Refiloe Masekela, et al.
… the WHO list of highest-TB burden countries. We identified drug-susceptible, drug-resistant, and consolidated guidelines through web searches and personal contacts within TB programs. We translated guidelines into English as needed and systematically extracted, recorded, and rev…
Svetlana G. Frolova, В. Н. Даниленко, Dmitry A. Maslov
The spread of drug-resistant strains of Mycobacterium tuberculosis is a major threat to the global control of tuberculosis (TB), urging the need to constantly develop new anti-TB drugs. Tryptanthrins are convenient compounds for the development of candidate anti-TB drugs due to t…
Li X, Qi X, Wang B, Fu L, Chen X, et al.
Background The lengthy duration and high frequency of drug resistance associated with currently used antimycobacterial drug treatments have intensified the need for alternative therapies against Mycobacterium tuberculosis, the causative agent of TB. Methods MICs and intracellular…
Silvia S. Chiang, Helen E. Jenkins
…a national surveillance database of individuals treated for drug-susceptible TB. The study includes ∼85 000 HIV coinfected children and adolescents, of whom nearly one-half were not receiving ART at TB diagnosis. The authors found that, compared with HIV-uninfected children and a…
Gilbert Eshun, Umaru Sesay, Augustus Osborne
…catastrophic costs due to TB. Inequalities were assessed by drug resistance status, comparing drug-susceptible TB (DS-TB) and drug-resistant TB (DR-TB), using four summary measures: Difference (D), Ratio (R), Population Attributable Risk (PAR), and Population Attributable Fractio…
Sadovska D, Nodieva A, Pole I, Ķimsis J, Vīksna A, et al.
…IT53 (n=9), and SIT254 (n=7) spoligotypes, and in 27 cases, resistance to at least one anti-TB drug was found in either isolate. Drug susceptibility was more common in the recurrent TB patient cohort, and longitudinal single TB episode isolates were more prone to be drug-resistan…
Huang CK, Yu MC, Hung CS, Lin JC
Pyrazinamide (PZA) is considered to be a pivotal drug to shorten the treatment of both drug-susceptible and drug-resistant tuberculosis, but its use is challenged by the reliability of drug-susceptibility testing (DST). PZA resistance in Mycobacterium tuberculosis (MTB) is releva…
Du W, Zhao Y, Zhang C, Zhang L, Zhou L, et al.
…an provide valuable information for preventing and treating drug resistant tuberculosis (DR-TB). High-throughput 16S rRNA sequencing was employed to analyze the bacteriome in pulmonary TB lesions from 14 patients with DR-TB and 47 patients with drug sensitive tuberculosis (DS-TB)…
Du W, Zhao Y, Zhang C, Zhang L, Zhou L, et al.
…an provide valuable information for preventing and treating drug resistant tuberculosis (DR-TB). High-throughput 16S rRNA sequencing was employed to analyze the bacteriome in pulmonary TB lesions from 14 patients with DR-TB and 47 patients with drug sensitive tuberculosis (DS-TB)…
Kumar Sahoo S, Naiyaz Ahmad M, Kaul G, Nanduri S, Dasgupta A, et al.
In pursuit of potent anti-TB agents active against drug resistant tuberculosis (DR-TB), herein we report synthesis and bio-evaluation of a new series of isoxazole-carboxylic acid methyl ester based 2-substituted quinoline derivatives. Preliminary evaluation indicated selectivity …
Zhang J, Lair C, Roubert C, Amaning K, Barrio MB, et al.
The emergence of drug-resistant tuberculosis has created an urgent need for new anti-tubercular agents. Here, we report the discovery of a series of macrolides called sequanamycins with outstanding in vitro and in vivo activity against Mycobacterium tuberculosis (Mtb). Sequanamyc…
Stadler JAM, Maartens G, Meintjes G, Wasserman S
… months), fully oral regimens containing new and repurposed drugs are now the first-choice option for the treatment of drug-resistant tuberculosis (DR-TB). Clofazimine, long used in the treatment of leprosy, is one such repurposed drug that has become a cornerstone of DR-TB treat…
Ellis T, Chiappi M, García-Trenco A, Al-Ejji M, Sarkar S, et al.
…he administration of antibiotics through the development of resistance mechanisms. By rapidly exporting drugs from within the cytosol, these pathogenic bacteria diminish antibiotic potency and drive the presentation of drug-tolerant tuberculosis (TB). The membrane integrity of M.…
Frolova SG, Klimina KM, Kumar R, Vatlin AA, Salunke DB, et al.
…over 1 million deaths annually. The emergence and spread of drug-resistant M. tuberculosis strains (MDR-, XDR- and TDR-TB) is the main challenge in global TB-control, requiring the development of novel drugs acting on new biotargets, thus able to overcome the drug-resistance. Try…
Pujiaty SC, Magdalena SBY, Parluhutan S, Rina Y, Sari WA
… June 2020 to May 2022, involving inpatients diagnosed with drug-sensitive or drug-resistant TB. The data was analyzed from total sampling subjects based on medical records. Results From 125 pulmonary TB patients, 64% had drug-sensitive TB (DS-TB) and 36% had drug-resistant TB (D…
Huan Xia, Zaixing Pan, Yun Hong, Qingzhu Zhao, Weili Fan
…categorized into Beijing and non-Beijing genotype families. Drug susceptibility testing (DST) was performed. All patients underwent pretreatment chest computed tomography (CT), which was evaluated using a semi-quantitative CT severity score (range 0-30) and assessed for key imagi…
Argita D. Salindri
… C co-infections) and post-TB mortality among patients with drug-resistant TB (DRTB) between 2009-2017 (n=1,032). Competing risks models were used to estimate the hazard rate of all-cause mortality post-TB treatment comparing DRTB patients with and without comorbidities. We repor…
Kilinç G, Saris A, Ottenhoff THM, Haks MC
…ntional antibiotics: (a) HDTs can be effective against both drug-resistant and drug-susceptible bacteria, as well as potentially dormant mycobacteria; (b) HDTs are less likely to induce bacterial drug resistance; and (c) HDTs could synergize with, or shorten antibiotic treatment …
Muhammad Shahzad
…of the most difficult to treat infections that require multidrug therapy for prolonged periods, in most cases 6-9 months. Treatment failure is still common and frequently observed (even where adherence to antibiotic therapy is maintained) in 15% of drug-susceptible infections and…
Yadav VD, Boshoff HI, Trifonov L, Roma JSO, Ioerger TR, et al.
The continuing prevalence of drug-resistant tuberculosis threatens global TB control programs, highlighting the need to discover new drug candidates to feed the drug development pipeline. In this study, we describe a high-throughput screening hit (4-benzylpiperidin-1-yl)(1-(5-phe…
Megerso A, Deyessa N, Jarso G, Worku A
…urse directly observed treatment,where patients should take drugs under direct observasion of health care providers, is uniformly applied all over the country. Evidences are scarce on how well does this uniform approach fits with the pastoral community setting. The purpose of thi…
Janmejaya Samal, Ranjit Kumar Dehury, M Benson Thomas, Hari Singh
…r quality of life, low medication adherence, progression to drug-resistant tuberculosis, and ultimately, mortality. **OBJECTIVES:** This study aimed to estimate the pooled prevalence of depression in TB patients and identify the predictors of depression in this population in Ind…
Lun S, Tasneen R, Chaira T, Stec J, Onajole OK, et al.
…e infection model. Since indoleamides are equally active on drug-resistant M. tuberculosis , these findings demonstrate the therapeutic potential of this novel scaffold for the treatment of both drug-susceptible and drug-resistant tuberculosis.
Т. Е. Кононова, О. И. Уразова, V. A. Serebryakova, С. П. Чумакова, O. A. Vasilyeva, et al.
…gene in lymphocytes. Results. In patients with infiltrative drug susceptible and drug resistant pulmonary tuberculosis against the background of normal production of IL-23 by dendritic cells, an increase in blood level of Th17 lymphocytes and the level of mRNA of the RORC2 transc…