Showing 101–125 of 200 documents
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Hu Y, Zheng X, Davies Forsman L, Ning Z, Chen C, et al.
Objectives Little is known about how additional second-line drug resistance emerges during multidrug-resistant tuberculosis (MDR-TB) treatment. The present study aimed to investigate the influence of microevolution, exogenous reinfection and mixed infection on second-line drug re…
Che Y, Lin Y, Yang T, Chen T, Sang G, et al.
Setting Controlling drug-resistant tuberculosis in Ningbo, China. Objective Whole-genome sequencing (WGS) has not been employed to comprehensively study Mycobacterium tuberculosis isolates, especially rifampicin-resistant tuberculosis , in Ningbo, China. Here, we aim to character…
Alyssa Schami, M. Nurul Islam, Matthew J. Wall, Amberlee Hicks, Reagan J. Meredith, et al.
…the top infectious killers in the world. In recent decades, drug resistant (DR) strains of M.tb have emerged that make TB even more difficult to treat and pose a threat to public health. M.tb has a complex cell envelope that provides protection to the bacterium from chemotherapeu…
Jaber AAS, Ibrahim B
…nization (WHO) has reported that Yemen has a high burden of drug resistance and a worrying shortage of implemented diagnostic methods and drug treatment regimens. Therefore, in this study, we evaluated the risk factors associated with multidrug-resistant tuberculosis (MDR-TB) and…
Abebaw Y, Abebe M, Tola HH, Mehammed Z, Getahun M, et al.
…acteriologically confirmed childhood Tuberculosis (PTB) and drug-resistant TB in Ethiopia is limited due to difficulties related to its diagnosis in this population. Therefore, this study aimed to assess bacteriologically confirmed childhood PTB Case Notification Rates (CNRs) and…
Anila Jaleel, Farouk Qamar Malik, Imran Ali Zaidi, Sana Hafeez, Kiran Namoos
…se which is approximately 270 per 100,000. The emergence of drug resistant MTB poses a serious threat to the ongoing efforts to control the disease epidemic. Drug resistance to the first line drugs such as Isoniazid (INH) and Rifampicin (RIF) needs to be investigated. In this res…
Xu P, Li M, Jiang Q, Yang C, Liu X, et al.
Objective Drug resistance is the critical determinant for appropriate tuberculosis (TB) treatment regimens and an important indicator of the local TB burden. We aimed to investigate and compare trends in TB drug resistance in the urban Songjiang District of Shanghai from 2011 to …
Bhosale S, Prabhakar A, Srivastava S, Raj A, Purohit S, et al.
…of cases among extra pulmonary osteoarticular tuberculosis. Resistance to drugs in spinal tuberculosis patients is on a rise and there is inadequate literature concentrating on the precise pattern of resistance in Indian subcontinent which harbors 24% of global prevalence. The ai…
Chen Yang, Guangchuan Dai, Yicheng Guo, Tianzhen Wang, Weiwei Gao, et al.
**BACKGROUND:** Drug-resistant tuberculosis has emerged as a major public health issue that requires immediate attention. NTS is an innovative method that allows for the direct detection of clinical samples without the need for culture. It could provide more accurate, reliable, a…
Anderson K, Pietersen E, Shepherd BE, Bian A, Dheda K, et al.
…een HIV-positive and HIV-negative South African adults with drug-resistant tuberculosis (DR-TB) and high incidence of acquired second-line drug resistance. Methods We performed a retrospective review of DR-TB patients with serial second-line TB drug susceptibility tests (2008-201…
Satyendra N. Shukla, Nitin Bhardwaj, Ashutosh Singh
…has emerged as a health risk due to its ability to adapt to drugs . The emergence of drug-resistant Mtb is affected by factors such as drug-resistant gene mutations, the efficacy of TB treatment, genetic background of the strain, and its ability to adapt to host and specific envi…
Suman SK, Chandrasekaran N, Priya Doss CG
…b ) and has become increasingly challenging to treat due to drug resistance. The World Health Organization declared TB a global health emergency in 1993. Drug resistance in TB is driven by mutations in the bacterial genome that can be influenced by prolonged drug exposure and poo…
Osei-Wusu S, Amo Omari M, Asante-Poku A, Darko Otchere I, Asare P, et al.
Background Drug resistance surveillance is crucial for tuberculosis (TB) control. Therefore, our goal was to determine the prevalence of second-line anti-TB drug resistance among diverse primary drug-resistant Mycobacterium tuberculosis complex (MTBC) isolates in Ghana. Materials…
Yiwang Chen, Howard Takiff, Qian Gao
…g (WGS) has shown great potential in the rapid diagnosis of drug-resistant tuberculosis;1Finci I Albertini A Merker M et al.Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multice…
Balasundaram Revathi Mani, Usharani Brammacharry, Venkateswari Ramachandra, Suganthi Palavesam, Muthuraj Muthaiah
The emergence of drug-resistant tuberculosis jeopardizes the TB control programme activities globally. Multidrug-resistant TB is defined as tuberculosis strains resistant to at least two first-line drugs, rifampicin (RIF) and isoniazid (INH). Extensively drug-resistant TB refers …
Bhat ZS, Rather MA, Ul Lah H, Hussain A, Maqbool M, et al.
…cidal agents that can shorten treatment duration and target drug resistance still remain a top priority in the discovery of anti-TB drugs. The objective of this study was to investigate the bactericidal potential of 3-cinnamoyl-4-hydroxy-6-methyl-2-pyrone (CHP) against drug-susce…
Oostvogels S, Ley SD, Heupink TH, Dippenaar A, Streicher EM, et al.
Extensively drug-resistant tuberculosis (XDR-TB), defined as resistance to at least isoniazid (INH), rifampicin (RIF), a fluoroquinolone (FQ) and a second-line injectable drug (SLID), is difficult to treat and poses a major threat to TB control. The transmission dynamics and dist…
Paryani RH, Gupta V, Singh P, Verma M, Sheikh S, et al.
… is high among household contacts (HHCs) of pre-extensively drug resistant (pre-XDR) TB and XDR-TB, data on yield of systematic longitudinal screening are lacking. We aim to describe the yield of systematic longitudinal TB contact tracing among HHCs of patients with pre-XDR-TB an…
Norbert Ndjeka, Nazir Ismail
Bedaquiline, a novel therapeutic drug, and clofazimine, a re-purposed drug, are front-line therapies recommended by WHO to treat rifampicin-resistant or multidrug-resistant tuberculosis. Both drugs have been in use in South Africa at least 10 years: bedaquiline since 2007 and clo…
Sharma AK, Gupta N, Kala DK, Patni T, Dixit R, et al.
…s and objectives To determine the prevalence and pattern of resistance to second line drugs among multi drug resistant (MDR) tuberculosis patients being treated on category IV regimen. Methodology This study was conducted at Department of Respiratory Medicine, J.L.N. Medical Coll…
Shah V, Yogesh M, Kothari DR, Gandhi RB, Nagda JJ
Background Characterizing risk factors for drug-resistant tuberculosis (TB) is critical to guide targeted interventions in high-burden settings like India. We aimed to identify socioeconomic, lifestyle, and clinical factors associated with drug-sensitive and drug-resistant TB acq…
Hiral Gadhavi, Akansha Goyal, Binita Aring, Summaiya Mullan
The rate of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) has been steadily increasing in developing countries like India. The availability of rapid and reliable methods for the detection of drug resistance to second-line drugs is vital for adeq…
David Kajoba Mumena, Geoffrey Kwenda, Caroline Ngugi, Andrew Nyerere
Drug-Resistant Tuberculosis (DR-TB) causes high mortality and morbidity rates globally. DR-TB and COVID-19 pandemic are posing a major risk to global public health and economic security, and are jeopardizing efforts in the control, prevention and elimination of TB globally. Mycob…
Platon Eliseev, Irina Vasilyeva, Anatoly Vinokurov, E. A. Kuznetsov, Kirill Baibekov, et al.
…utations in M. tuberculosis (MTB) associated with delamanid drug resistance in patients with tuberculosis (TB) in Russia. Delamanid is important in treatment of multi- and extensively drug-resistant TB. Reports on delamanid drug resistance are increasing making it necessary to pe…
Liu D, Huang F, Zhang G, He W, Ou X, et al.
Objectives Phenotypic drug susceptibility testing for prediction of tuberculosis (TB) drug resistance is slow and unreliable, limiting individualized therapy and monitoring of national TB data. Our study evaluated whole-genome sequencing (WGS) for its predictive accuracy, use in …