Showing 76–100 of 200 documents
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Bæk O, Schaltz-Buchholzer F, Campbell A, Amenyogbe N, Campbell J, et al.
…ntentionally targeted pathogen) effects of BCG and smallpox vaccines hold significant translational potential. Yet despite their use for centuries, how scar formation occurs and how local skin-based events relate to systemic effects that allow these two vaccines to deliver powerf…
van Meijgaarden KE, Li W, Moorlag SJCFM, Koeken VACM, Koenen HJPM, et al.
Bacillus Calmette-Guèrin - vaccination induces not only protection in infants and young children against severe forms of tuberculosis, but also against non-tuberculosis related all-cause mortality. To delineate different factors influencing mycobacterial growth control, here we f…
Chatzikleanthous D, O'Hagan DT, Adamo R
…re are still unmet needs that may enable the development of vaccines suitable for more challenging pathogens (e.g., HIV and tuberculosis) and for cancer vaccines. Liposomes have already been shown to be highly effective as adjuvant/delivery systems due to their versatility and li…
Joanna J Regan, Zanju Wang, Christina R Phares
… the 4 weeks following live-virus vaccination because these vaccines are thought to increase the risk of false-negative results. **METHODS:** We retrospectively analyzed TST and IGRA results for 158 484 US-bound immigrant and refugee children aged 2-14 years who received …
Joan Joseph-Munné, Milena Maya-Hoyos, Narcís Saubi, Santiago Perez, Miguel Angel Martinez Lopez, et al.
During 2022, AIDS claimed a life every minute and about 9.2 million HIV-infected people were not on treatment. In addition, a person living with HIV is estimated to be 20-30 times more susceptible to developing active tuberculosis. Every year, 130,000 infants are newly infected, …
Ari MM, Beig M, Sholeh M, Khoshmirsafa M
…usative agent for this infection. Different antibiotics and vaccines have been discussed as potential treatments and prevention. Currently, there is only one licensed vaccine against TB, Bacillus Calmette-Guérin (BCG). Despite its protective efficacy against TB in children, BCG h…
Engi Seif E. Shaker, Noha Nabil Doghim, Arwa M. Hassan, Samia S. Musafa, Mohamed M. Fawzy
BACKGROUND: Warts are common viral infection of the skin. Treating warts are still an ongoing challenge and no general agreement is reached, on the best treatment, despite different therapeutic approaches. Intralesional (IL) immunotherapy has recently been shown to be effective i…
U. Yu. Sirodzhidinova, U. I. Rozikov, S. M. Saydaliev, J. M. Yusupdzhanova
Aim . To study morphological changes in the lymph nodes of experimental animals vaccinated with BCG vaccine in high and low mountains. Material and Methods . Guinea pigs from the vivarium of the Central Research Laboratory of the Avicenna Tajik State Medical University were used …
Александр Сидорчук, Александр Сидорчук
The article describes the historical stages of creating vaccines against two of the most dangerous diseases, which, after the discovery of the microbial theory, were devoted to the efforts of scientists ― rabies and tuberculosis. The lecture describes the main achievements of L. …
Fleck-Vidal C, Doubell A, Gerke C, Lamichhane U, Ogilvie L, et al.
Background Vaccines are critical tools to prevent the emergence and spread of antimicrobial resistance (AMR) through prevention of infection and reduction of subsequent antibiotic use. Since AMR is a critical issue disproportionately affecting Low- and Middle- Income Countries (L…
Aspatwar A, Gong W, Wang S, Wu X, Parkkila S
Bacillus Calmette-Guérin (BCG) is a live attenuated M. bovis vaccine that was developed about 100 years ago by Albert Calmette and Camille Guérin. Many countries have been using the vaccine for decades against tuberculosis (TB). The World Health Organization (WHO) recommends a si…
Mobed A
…ucted the present study to provide an overview of DNA based vaccines against TB and highlight the vaccine delivery advances and limitations. This study also aimed to bring a review of mycobacterial antigens, including heat shock protein 65 (Hsp65), antigen 85A (Ag85A), early secr…
Rakshit S, Adiga V, Ahmed A, Parthiban C, Chetan Kumar N, et al.
… adaptive immune responses to current and emerging COVID-19 vaccines.
Riccomi A, Piccaro G, Christensen D, Palma C, Andersen P, et al.
Most microbes invading through mucosal surfaces cause disease and therefore strategies to induce mucosal immune responses are strongly needed. Vitamin A metabolites, such as retinoic acid (RA), play crucial roles in programming T and B cells to home to mucosal compartments, there…
Hotez PJ
…ment over the potential development and introduction of new vaccines to prevent highly lethal respiratory virus infections, as well as tuberculosis, malaria, HIV/AIDS and several neglected tropical diseases. However, these successes are under threat due to political instability, …
А. M. Kostinov, М. П. Костинов
… provides data showing the nonspecific effect of preventive vaccines, such as pneumococcus, tuberculosis, and influenza, on the parameters of innate and adaptive immunity, which is reflected in a reduction of susceptibility not only to vaccine antigens, but also to other infectio…
Ouaked N, Demoitié MA, Godfroid F, Mortier MC, Vanloubbeeck Y, et al.
A new efficacious tuberculosis vaccine targeting adolescents/adults represents an urgent medical need. The M72/AS01 E vaccine candidate protected half of the latently-infected adults against progression to pulmonary tuberculosis in a Phase IIb trial (NCT01755598). We report that …
van den Berg RA, De Mot L, Leroux-Roels G, Bechtold V, Clement F, et al.
Systems biology has the potential to identify gene signatures associated with vaccine immunogenicity and protective efficacy. The main objective of this study was to identify optimal postvaccination time points for evaluating peripheral blood RNA expression profiles in relation t…
Berendsen MLT, Øland CB, Bles P, Jensen AKG, Kofoed PE, et al.
Background and hypothesis Maternal priming might enhance the beneficial nonspecific effects (NSEs) of live measles vaccination (MV). Children with a bacillus Calmette-Guérin (BCG) vaccine scar have a lower mortality rate than those without a scar that is not explained by protecti…
Gupta PK
Mycobacterium bovis BCG, a live attenuated tuberculosis vaccine offers protection against disseminated TB in children. BCG exhibits heterologous protective effects against unrelated infections and reduces infant mortality due to non-mycobacterial infections. Recent reports have s…
Larsen SE, Baldwin SL, Coler RN
…entified alternative approaches to improve upon traditional vaccines that are based on killed pathogens, live attenuated agents, or subunit recombinant antigens formulated with adjuvants. Massive funding and rapid advances in RNA-based vaccines for immunization have recently tran…
Beura LK, Jameson SC, Masopust D
Although CD8 T-cell vaccines do not have the record of success of humoral-mediated vaccines, they do not receive the same degree of effort. Many diseases, including malaria, tuberculosis, and acquired immune deficiency syndrome (AIDS) have not yielded to vaccines, and intrinsic b…
Barchitta M, Basile G, Lopalco PL, Agodi A
Protection of healthcare workers (HCWs) from biological hazards in the workplace has the added benefit of contributing to the quality of patient care and patient safety. Vaccinated HCWs act as a barrier against the spread of infections and maintain essential healthcare delivery d…
Tatyana Zubkova
The aim of the study is to investigate safety, reactogenicity and immunogenicity of the TB/Flu-05E single-dose intranasal vaccine for the prevention of Tuberculosis infection in BCG-vaccinated Volunteers aged 18-50 years. Study include 51 participants in two cohorts. At the firs…
Helen McShane, Alison Elliot
Mycobacterium tuberculosis (M. tb) is a pathogen with worldwide distribution which infects humans causing tuberculosis (TB), a transmissible disease resulting in very high mortality and morbidity; development of an effective vaccine is a global health priority. Over a billion pe…