SUSCEPTIBILITY OF PEOPLE VACCINATED AGAINST S. PNEUMONIAE TO SARS-COV-2 – MECHANISMS OF NON-SPECIFIC ACTION OF PNEUMOCOCCAL VACCINE

The review provides data showing the nonspecific effect of preventive vaccines, such as pneumococcus, tuberculosis, and influenza, on the parameters of innate and adaptive immunity, which is reflected in a reduction of susceptibility not only to vaccine antigens, but also to other infectious pathogens. It is also discussed possible variants of immune mechanisms activation after the receiving a pneumococcal vaccine, especially conjugated polysaccharide vaccine, and their role in the interaction between the organism and the new SARS-CoV-2 coronavirus. Three variants of the nonspecific action of the vaccine are considered as the most probable: antigen mimicry, nonspecific activation and trained immunity.