Showing 76–100 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Taiwo Isaac Olatunji, M.M. Suleiman, Olatunji Matthew Kolawole
…nsively drug-resistant (XDR) TB, alongside high rates of TB-HIV co-infection. Recognizing these gaps, attention has turned to traditional medicinal plants as potential sources of novel anti-TB compounds. This paper explores the epidemiology of TB, the urgent need for new therapeu…
Zhang P, Xiong J, Zeng J, Zhan S, Chen T, et al.
…pe in both groups (65.1% vs 77.0%). Advanced TB (23.4%) and HIV co-infection (20.8%) were the leading causes of deaths in the young group, but deaths in the elderly group were mostly associated with underlying diseases, including cardiovascular disease (52.9%), diabetes (33.3%), …
Mvelase NR, Balakrishna Y, Lutchminarain K, Mlisana K
…ll benefit patients with RMR. Although DR-TB is widespread, HIV and migration influence its distribution; therefore, TB control strategies should include interventions that target these aspects.
Valencia-Trujillo D, Avila-Trejo AM, García-Reyes RL, Narváez-Díaz L, Mújica-Sánchez MA, et al.
…tality rates in patients with human immunodeficiency virus (HIV). In Mexico, the number of deaths due to TB among the HIV-positive population has tripled in recent years. Methods Ninety-three Mycobacterium tuberculosis strains isolated from the same number of HIV-infected patient…
V.I. Petrenko, O.V. Panasiuk, G.V. Radysh, Sergiy Antonyak, Oleksander Holub, et al.
…y localization organs with multi and extended resistance in HIV-positive patients, depending on the speed of diagnosis of TB and timely adequate antimycobacterial therapy (AMBT) with antiretroviral therapy (ART).Materials and methods. The clinical study involved 44 adult HIV-posi…
World Health Organization. Regional Office for Europe
…vely drug-resistant forms of TB (XDR-TB) and an increase of HIV coinfection, if not adequately addressed, will threaten the Region's ability to achieve the 2030 End TB Strategy targets. A modified Delphi consultation of core experts in the Region was used to obtain a set of resea…
T.I. Danilova, Yu.V. Korneev, D.А. Kudlаy, N. Yu. Nikolenko
…d extensive drug resistance (MDR/XDR MTB). Patients with TB/HIV co-infection providethe significant impact on the situation. The objective of the study is to assess outcomes of chemotherapy regimens containing bedaquiline in patients with MDR/XDR TB including those with concurren…
Oki Nugraha Putra, Telly Purnamasari
… MDR-TB; (2) Adults or adolescents > 14 years regardless of HIV status; (3) Patients with pulmonary TB and all form of extrapulmonary TB, except for central nervous system, osteoarticular, and milary TB; (4) Patients had not received bedaquiline, pretomanid, linezolid, or delaman…
Regional Committee for Africa, 60
…in 2007. An estimated 51% of TB patientstested in 2007 were HIV-positive, making HIV infection the single most important risk factor forTB incidence in the Region. The current TB trends need to be reversed for the African Region tomeet the Millennium Development Goals (MDG).2. At…
Bvumbi MV
…ely drug-resistant TB (XDR-TB) strains. Factors such as the HIV pandemic contribute further. Also, the ineffectiveness of the chemotherapy in current use increases the mortality rate. Therefore, new and repurposed antituberculosis drugs are urgently needed for the treatment of MD…
Zhao XY, Zeng ZY, Hua WH, Yu YH, Guo CP, et al.
A retrospective analysis was performed in two major HIV/AIDS referral hospitals in Beijing to evaluate the prevalence of Mycobacterium tuberculosis (MTB) and non-tuberculous mycobacterial (NTM) infections in HIV-infected patients. A total of 627 patients' data were reviewed, and …
Morrish Okello-Obol, Ivaan Pitua, James Nelson Okema, Doris Ekwem, Felix Bongomin, et al.
…f drug-resistant TB (DR-TB) and its strong association with HIV. Bedaquiline (BDQ), approved by the WHO in 2013, offers a promising treatment for DR-TB, including multidrug-resistant TB (MDR-TB) and extensively DR-TB (XDR-TB). However, BDQ has been associated with QT interval pro…
Habous M, Elimam M, AlDabal L, Chidambaran B, AlDeesi Z
…he extent of association with human immunodeficiency virus (HIV) and diabetes mellitus (DM). Method This is a retrospective analysis of 1116 clinical isolates were collected from patients who were newly diagnosed with TB at TB Laboratory between January 2016 and November 2019 and…
Human Sciences Research Council
…m has been incrementally implemented in Khayelitsha, a high HIV and TB burden community in South Africa. We investigated loss from treatment (LFT), and post treatment outcomes of DR-TB patients in this setting. LFT, defined as interruption of treatment for 2 consecutive months wa…
Ruth Chipampe Kafwanka, Rogers Chilyabanyama, Richard Chirwa, Mubanga Lackson Chipimo
…strategies. Key risk factors include previous TB treatment, HIV co-infection, delayed diagnosis, and poor treatment adherence. Diagnostic challenges persist, with limited access to drug susceptibility testing (DST) and delayed MDR-TB detection contributing to prolonged infectious…
Martina L. Reichmuth, Kathrin Zürcher, Marie Ballif, Chloé Loiseau, Sònia Borrell, et al.
… patients in Africa, Latin America, and Asia, stratified by HIV status and drug resistance, from 2013 to 2016. Participating sites performed drug susceptibility testing (DST) locally, using routinely available methods. WGS was done using Illumina HiSeq 2500 at laboratories in the…
Rajesh Nanaware, Anuruddha R. Chabukswar, Vishal Tekade, Kunal Kashid, Tejas Vidhate, et al.
…tiretroviral medications because many TB patients also have HIV. Additionally, it must work well with other anti-TB medications to form at least an effective three-drug regimen. This article discusses the analysis of a few FDA-approved anti-tubercular medications and their bindin…
Olayanju O, Esmail A, Limberis J, Gina P, Dheda K
…e relationship between these are lacking from resource-poor HIV-endemic settings. Methods This was a prospective follow-up study of 63 South African XDR-TB patients (58.7% HIV-infected; median CD4 131 cells/μl) between 2014 and 2018. The frequency and severity of linezolid-associ…
Chawla GK, Garg K, Kaur K, Chopra V, Suri R
…ir association with diabetes, human immunodeficiency virus (HIV), previous history of tuberculosis (TB) and family history of TB. Method Sputum specimens obtained from 11,874 pulmonary tuberculosis patients were subjected to smear microscopy, cartridge based nucleic acid amplific…
Johnson JM, Mohapatra AK, Velladath SU, Shettigar KS
… There were 68.2% of new and 31.8% retreatment cases of TB. HIV co-infection was found in 2.3% (n = 14) of TB cases, and among them, 64.3% (n = 9) were found in PTB cases. The major comorbidities found were diabetes (21.2%), weight loss (12.6%), and anemia (12.6%). There was a di…
Chaves Torres NM, Quijano Rodríguez JJ, Porras Andrade PS, Arriaga MB, Netto EM
… was 84.8% (95% CI: 77.7-90.7); in patients coinfected with HIV, it was 71.0% (95% CI: 63.7-77.8), in patients with multidrug-resistant TB, it was 58.4% (95% CI: 51.4-64.6), in patients with and extensively drug-resistant TB it was 27.1% (12.7-44.5). Patients with negative sputum…
Sharenja Ratnakumar, Xin Yi Choon, Moerida Belton, Paramita Palchaudhuri, Louise Cotton
…TB was high, 82%.11% had previous diagnosis of TB. Of those HIV tested, 10% were positive cf. Europe-wide rates of 4.5%. 6.4% had isoniazid resistance (INH-R); 3.2% MDRTB; 3.2% extremely drug resistant TB (XDRTB). Completion of treatment was confirmed in 84%; 11% transferring car…
Misra N, Padayatchi N, Naidoo P
…) were <50 kg and 390 (90.5%) ≥50 kg. Overall 77.2% were HIV-positive, with 93.95% on antiretroviral medicine. The majority of patients presented with extremely drug-resistant TB (55.3%). Forty-seven and a half percent of patients received a standardised background regimen, an…
John Metcalfe, Peter Bacchetti, Aliasgar Esmail, Andrew Reckers, David Aguilar, et al.
…for all drugs except isoniazid) using an external cohort of HIV-positive patients treated for latent TB infection with daily isoniazid (HIV/LTBI cohort) in Uganda. Results Among the 57 DR-TB patients (58% with pre-XDR/XDR-TB; 70% HIV-positive) contributing analyzable hair samples…
Metcalfe J, Bacchetti P, Esmail A, Reckers A, Aguilar D, et al.
…for all drugs except isoniazid) using an external cohort of HIV-positive patients treated for latent TB infection with daily isoniazid (HIV/LTBI cohort) in Uganda. Results Among the 57 DR-TB patients (58% with pre-XDR/XDR-TB; 70% HIV-positive) contributing analyzable hair samples…