Showing 76–100 of 200 documents
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Maria Norrby
…s long been in use. Globally, human immunodeficiency virus (HIV) is the single strongest medical risk factor for active TB. The implementation of anti-retroviral treatment (ART) in 1996 completely changed the prognosis for persons living with HIV. By restituting the immune defens…
Chiacchio T, Petruccioli E, Vanini V, Cuzzi G, La Manna MP, et al.
Background Human Immunodeficiency Virus (HIV) infection is a risk factor for tuberculosis (TB). Antiretroviral therapy (ART) changed HIV clinical management but it is still unclear how pre-existing HIV/Mycobacterium tuberculosis (Mtb)-specific CD4 + and CD8 + T-cells are restored…
Capocci SJ, Sewell J, Smith C, Cropley I, Bhagani S, et al.
…esting for latent TB infection (LTBI) in people living with HIV. However there are few cost-effectiveness studies to justify this in contemporary high resource, low TB/HIV incidence settings. We sought to assess the uptake, yield and cost-effectiveness of testing for latent and a…
Jintanat Ananworanich, MD, PhD, Piyarat Suntarattiwong, MD, Simon Tsiouris, MD, MPH
…udy to improve the diagnosis and management of latent TB in HIV-infected and HIV uninfected children in Thailand. The objectives are to assess the sensitivity and specificity of IGRAs (T-Spot®.TB, a T-cell-based assay, and QuantiFERON®-TB Gold In-tube, a whole blood assay), TST, …
Devalraju KP, Neela VSK, Gaddam R, Chaudhury A, Van A, et al.
HIV infection markedly increases the likelihood of latent tuberculosis infection progressing to active TB. Information on expression of TLR-2, myeloid differentiation factor (MyD88), IL-1R- associated kinase-4 (IRAK4) and nuclear factor kappa B (NF-kB) in HIV+LTBI+ and HIV+ patie…
Marc Lipman, MD
Human Immunodeficiency Virus (HIV) is the strongest individual risk factor for the reactivation of tuberculosis (TB) after previous exposure to Mycobacterium tuberculosis (MTb). This risk is reduced but not completely eliminated when HIV is treated with antiretroviral therapy (AR…
Mulugeta T, Takale A, Umeta B, Terefe B
Background Human immune deficiency virus (HIV) increases the susceptibility to primary infection or reinfection and the risk of tuberculosis (TB) reactivation for patients with latent TB. There was no current report on the rate of active TB infection among HIV-1 infected patients…
Tavares AM, Garcia AC, Gama A, Abecasis AB, Viveiros M, et al.
…care providers are key interveners in the control of TB and HIV-TB infections. In this study, we aimed to explore the perspectives of healthcare providers working in primary care in Portugal about the provision of TB care for migrant patients with TB or HIV-TB co-infection. Metho…
Gebremicael G, Kassa D, Alemayehu Y, Gebreegziaxier A, Kassahun Y, et al.
…105 immune-related genes were determined in the blood of 80 HIV-negative study participants composed of 40 active TB cases, 20 latent TB infected individuals with positive tuberculin skin test (TST+), and 20 healthy controls with no Mycobacterium tuberculosis (Mtb) infection (TST…
Alimuddin Zumla, Jeremiah Chakaya, Mishal Khan, Razia Fatima, Christian Wejse, et al.
…19, and there were an estimated 1.2 million TB deaths among HIV-negative people and an additional 208,000 deaths among people living with HIV. In addition, preliminary assessments of how the unprecedented, devastating COVID-19 pandemic is affecting TB health services, interruptin…
Namugga JV, Musubika C, Niwagaba S, Mayito J, Sande OJ
…losis (TB) detection among asymptomatic Human Immune Virus (HIV) positive individuals using Interferon Gamma Release Assay (IGRA) (QuantiFERON-TB Gold Plus) as the gold standard and determine the factors associated with anti-MPT51 antibody positivity among asymptomatic HIV positi…
Ayele TK, Doungmo Goufo EF, Mugisha S
The co-epidemics of HIV/AIDS and Tuberculosis (TB) outbreak is one of a serious disease in Ethiopia that demands integrative approaches to combat its transmission. In contrast, epidemiological co-infection models often considered a single latent case and recovered individuals wit…
Queen Mary University of London
…t, an estimated 9.6 million new TB cases (12% of which were HIV co-infected) and 1.5 million deaths (of which 0.4 million were among HIV co-infected people) occurred globally in 2014.4 In addition, one third of the global population is estimated to have latent Mtb infection (LTBI…
Martin-Iguacel R, Llibre JM, Pedersen C, Obel N, Stærke NB, et al.
…Denmark in people living with human immunodeficiency virus (HIV) (PLWH). Methods In this nationwide, population-based cohort study we included all adult PLWH from the Danish HIV Cohort Study (1995-2017) without previous TB. We estimated TB incidence rate (IR), all-cause mortality…
Hook K, Sereda Y, Makarenko O, Bendiks S, Rybak NR, et al.
…rceived TB stigma have not been assessed specifically among HIV-positive people who inject drugs (PWIDs). It is also unclear how perceived TB stigma intersects with other forms of stigma affecting this population. We aimed to evaluate perceived TB stigma, its correlates and its i…
Rebecca F. Baggaley, Christopher Martin, Helen Eborall, Marjan Gohar, Kashif Aziz, et al.
…is (TB) with an interferon gamma release assay (IGRA) test, HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV) infection when patients first registered with general practices (GPs) in Leicester, UK, using test yields, numbers of new diagnoses and numbers linked to care. Fin…
Norrby M, Wannheden C, Ekström AM, Berggren I, Lindquist L
… factors of active tuberculosis (TB) in persons living with HIV in a low endemic setting over a 17-year time period when combination antiretroviral therapy (ART) has been available. We thereby aimed to understand the usefulness of TB chemoprophylaxis among HIV patients with laten…
José Cobeña-Reyes, Celestine N. Wanjalla, Manuel G. Feria, Joshua D. Simmons, Tecla M. Temu, et al.
…ound: Coronary artery disease (CAD), tuberculosis (TB), and HIV are major global health concerns. Individuals affected by one or more of these conditions often exhibit chronic inflammation and immune dysregulation, with monocytes playing a central role. Monocyte subsets are known…
José Cobeña-Reyes, Celestine N Wanjalla, Manuel G Feria, Joshua Simmons, Tecla Temu, et al.
…ND:** Coronary artery disease (CAD), tuberculosis (TB), and HIV are major global health concerns. Individuals affected by one or more of these conditions often exhibit chronic inflammation and immune dysregulation, with monocytes playing a central role. Monocyte subsets are known…
White HA
…is infection (LTBI) reactivation amongst people living with HIV (PLWH) remains significant, despite HIV virological control. Methods: Four studies were undertaken. A UK survey of HIV clinicians determined current LTBI screening practice in PLWH. An evaluation of the Leicester HIV…
М. В. Синицын, Evgeniy Belilovsky, E. M. Bogorodskaya, Borisov Se, D.А. Kudlаy, et al.
…ct Background The difficult epidemic situation caused by TB/HIV co-infection and, accordingly, the need to strengthen measures for the prevention of tuberculosis among HIV patients, identified the need to create a model of collaborating tuberculosis management facilities and AIDS…
Kulkarni S, Endsley JJ, Lai Z, Bradley T, Sharan R
Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) co-infection continues to pose a significant healthcare burden. HIV co-infection during TB predisposes the host to the reactivation of latent TB infection (LTBI), worsening disease conditions and mortality. There is a lack …
MRaveendran Nair
…ients include diabetes mellitus (DM), malnutrition, anemia, HIV, tobacco smoking, alcohol use, depression, and chronic lung diseases. Both pulmonary TB (PTB) and extra-PTB (EPTB) may cluster with the various comorbidities. Major comorbidities associated with active TB and the key…
Shui Shan Lee
…the hallmark of the immunocompromised state associated with HIV infection. In the last decade, advances in antiretroviral therapy (ART) and its early initiation have led to effective immune restoration in people living with HIV (PLHIV), as demonstrated by the significant reductio…
Hjelmar KJS, de Armas LR, Goldberg E, Pallikkuth S, Mathad J, et al.
…ection (LTBI) is a common coinfection in people living with HIV (PWH). How LTBI and HIV exposure in utero influence the development of infant humoral immunity is not well characterized. To address this question, we assessed the relationship between maternal humoral responses in p…