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Velayutham B, Jawahar MS, Nair D, Navaneethapandian P, Ponnuraja C, et al.
…iority. We tested the efficacy and safety of 3- and 4-month regimens containing moxifloxacin in a randomised clinical trial in pulmonary TB (PTB) patients in South India. Methods New, sputum-positive, adult, HIV-negative, non-diabetic PTB patients were randomised to 3- or 4-month…
Stagg HR, Thompson JA, Lipman MCI, Sloan DJ, Flook M, et al.
… nonadherence occurs on the forgiveness of antituberculosis regimens. Methods: Using data from three randomized controlled trials comparing experimental 4-month regimens for drug-sensitive tuberculosis with the standard 6-month regimen, we used generalized linear models to examin…
Xueyi Chen, Carlos E Ruiz-Gonzalez, Yuderleys Masias-Leon, Mantej Singh, Oscar J Nino-Meza, et al.
…ains unexplored.Figure 1.Evaluation of rifamycin-containing regimens in the mouse model of TB meningitis.(A) Mice were infected intraventricularly via Burr hole using a syringe and stereotaxic instrument, treatment were initiated two weeks after (designated as day 0) and continue…
Vesga JF, Lienhardt C, Nsengiyumva P, Campbell JR, Oxlade O, et al.
…en important improvements in available preventive treatment regimens for tuberculosis (TB), and research is ongoing to develop these further. To assist with the formulation of target product profiles for future regimens, we examined which regimen properties would be most influent…
Nicholas I Paton, Christopher Cousins, Intan P Sari, Erlina Burhan, Nan-Kai Ng, et al.
…D:** WHO recommends a 2-month optimal duration for new drug regimens for rifampicin-susceptible tuberculosis. We aimed to investigate the efficacy and safety of the 8-week regimens that were assessed as part of the TRUNCATE management strategy of the TRUNCATE-TB trial. **METHODS…
Goodall RL, Meredith SK, Nunn AJ, Bayissa A, Bhatnagar AK, et al.
…EAM stage 2, we aimed to compare two bedaquiline-containing regimens with the 9-month STREAM stage 1 regimen. Methods We did a randomised, phase 3, non-inferiority trial in 13 hospital clinics in seven countries, in individuals aged 15 years or older with rifampicin-resistant tub…
Marcela Muñoz-Torrico, Rafael Laniado-Laborín, Jorge Rojas-Serrano, Eduardo Becerril-Vargas, Wendy Cinecio-Chávez, et al.
…ere mainly related to linezolid use. **CONCLUSIONS:** Oral regimens appear to be effective, although toxicity to linezolid requires strict patient monitoring.
Bavesh D Kana
…ltaneously avoiding the L-associated AEs. The BPaL and BPaS regimens were compared in the Balb/c and C3HeB/FeJ murine chronic TB efficacy models. After 4-weeks of treatment, both regimens promoted equivalent bactericidal effect in both TB murine models. However, treatment with BP…
Malik Zohaib Ali, Taru S. Dutt, Amy L. MacNeill, Amanda Walz, Johnathan Patterson, et al.
…ltaneously avoiding the L-associated AEs. The BPaL and BPaS regimens were compared in the Balb/c and C3HeB/FeJ murine chronic TB efficacy models. After 4-weeks of treatment, both regimens promoted equivalent bactericidal effect in both TB murine models. However, treatment with BP…
Srikant Kashinath Malegaonkar, Valliappan Muthu, Ashutosh N. Aggarwal, Digambar Behera, Ritesh Agarwal
… article by Velayutham and colleagues, reporting on shorter regimens for newly diagnosed pulmonary tuberculosis [1]. Shortening the duration of tuberculosis treatment is an unmet research need [2]. In this regard, the trial by Velayutham et al. is commendable. Nevertheless, it ha…
Malik Zohaib Ali, Taru S. Dutt, Amy L. MacNeill, Amanda Walz, Johnathan Patterson, et al.
…ltaneously avoiding the L-associated AEs. The BPaL and BPaS regimens were compared in the Balb/c and C3HeB/FeJ murine chronic TB efficacy models. After 4-weeks of treatment, both regimens promoted equivalent bactericidal effect in both TB murine models. However, treatment with BP…
Malik Zohaib Ali, Taru S. Dutt, Amy L. MacNeill, Amanda Walz, Johnathan Patterson, et al.
…ltaneously avoiding the L-associated AEs. The BPaL and BPaS regimens were compared in the Balb/c and C3HeB/FeJ murine chronic TB efficacy models. After 4-weeks of treatment, both regimens promoted equivalent bactericidal effect in both TB murine models. However, treatment with BP…
Liu Y, Pertinez H, Davies GR, Gillespie SH, Coates AR, et al.
…oxifloxacin for isoniazid or ethambutol in standard anti-TB regimens reduces the treatment duration and relapse rates in animal studies, and 4-month regimens were not noninferior in clinical trials. Resuscitation-promoting factor (RPF)-dependent bacilli have recently been implica…
University College, London
…: The objective of the Phase 2B stage is to identify novel regimens of 16 weeks' duration with acceptable safety profile and the greatest potential, based on assessment of quantitative sputum liquid culture and treatment failure/relapse, to progress to investigation of optimal t…
Wenhong Zhang, PhD
The purpose of this study is to assess the efficacy, safety and tolerability of a combination of levofloxacin, linezolid, cycloserine and pyrazinamide (or clofazimine if resistant to pyrazinamide) treatments for 24 to 32 weeks (regimen consisted of clofazimine for 36\~44 weeks) i…
Soumya Swaminathan, MD MNAMS
…l trial to assess the efficacy of short course intermittent regimens for the treatment of HIV-associated tuberculosis Phase: Phase III trial Population: 300 HIV positive patients with tuberculosis. Number of Sites:Four 1. Tuberculosis Research Centre, Chennai 2. Government Ge…
Ju Mi Lee, Jiyun Park, Sang‐Won Choi, Byung Woo Jhun, Su‐Young Kim, et al.
…se (MAC-PD) remain unsatisfactory. Thus, improved treatment regimens for MAC-PD are required. Clofazimine has recently been revisited as an effective drug against mycobacterial infection. We performed a comparison between the standard regimen and an alternative regimen (replacing…
Suman Saurabh, Pankaj Bhardwaj
…ed as a key drug with its inclusion in all the standardized regimens for drug-resistant tuberculosis. Therefore, it is important to prevent the emergence of resistance to bedaquiline. Active drug safety monitoring (aDSM) should be rigorously implemented in addition to ensuring co…
Aliya Moreira, Dana Hassneiah, Susan E. Beekmann, Philip M. Polgreen, Maunank Shah, et al.
…e 2020, CDC guidance has preferentially recommended shorter regimens for tuberculosis (TB) infection and since 2022, recommendations include 6-month regimens for drug-resistant (DR-TB) disease containing bedaquiline, linezolid, and pretomanid (BPaL) and a 4-month regimen for drug…
Raehan Satya Deanasa, Arya Marganda Simanjuntak, Fara Syafira, Putri Mahirah Afladhanti, Anisa Hawari, et al.
… and moxifloxacin was active in ABSTRACT INTRODUCTION Newer regimens are needed and expected to have a shorter therapeutic time to increase drug adherence to completion in drug sensitive tuberculosis (DS-TB) patients.METHODS We conducted first a systematic review and meta-analysi…
Dr. Banurekha MBBS., MPH
The 4-month daily regimen containing moxifloxacin (2HRZEM 7 / 2HRM7) of ICMR-NIRT was studied in 321 sputum positive pulmonary TB patients in a randomised clinical trial. Of the 321, there were 96% with sputum smear grading of 2+/3+ and 80% with \>2 zone involvement in the chest …
Malik Zohaib Ali, Taru S. Dutt, Amy L. MacNeill, Amanda Walz, Camron Pearce, et al.
…ltaneously avoiding the L-associated AEs. The BPaL and BPaS regimens were compared in the BALB/c and C3HeB/FeJ murine chronic TB efficacy models. After 4-weeks of treatment, both regimens promoted equivalent bactericidal effect in both TB murine models. However, treatment with BP…
Adriana Chacón, Yamile Celis Bustos, Dany Martinez, Felix Chong, Clara Freile, et al.
…ogrammatic cohort, the nine-month all-oral shorter and BPaL regimens were associated with favorable treatment outcomes, acceptable safety profiles, improved adherence, and reduced loss to follow-up compared with injectable-based therapy. These findings supported Ecuador’s …
Kohler S, Sitali N, Achar J, Paul N
…nd their import are costly. We assessed how shorter TB drug regimens, which were non-inferior or superior in recent TB trials, can affect the costs for purchasing and importing TB drugs. Methods We estimated the drug costs and import costs of 39 longer and shorter TB drug regimen…
Ryckman TS, Schumacher SG, Lienhardt C, Sweeney S, Dowdy DW, et al.
…tent to which future improvements in tuberculosis treatment regimens could offset potential increases in drug costs. Methods In this modelling analysis, we used an ingredients-based approach to estimate prices at which novel regimens for rifampin-susceptible and rifampin-resistan…