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Özlem Tezol
Objectives: Pediatric tuberculosis is a major public health problem. Malnutrition characterized with wasting is prevalent among pediatric tuberculosis patients. We aimed to review pediatric tuberculosis cases by considering their nutrition manifestations. Materials and Methods: T…
Christiane Mello Schmidt, Claudete Aparecida Araújo Cardoso, Rafaela Baroni Aurílio, Maria de Fátima Bazhuni Pombo Sant’ Anna, Clemax Couto Sant’Anna
As children develop paucibacillary forms of tuberculosis (TB), bacteriological tests usually are negative. This chapter describes aspects of the laboratory tests available for clinical practicePractice. It also discusses perspectives, such as biomarkers, which can be utilized in …
Pace D, Pellegrino R, Dalpiaz I, Renni M, Galli L, et al.
Introduction The diagnosis of pediatric tuberculosis (TB) is challenging, due to the lower sensitivity of microbiological tests, such as culture and microscopy, compared to their performance in adult cases. Guidelines have introduced molecular tests, including GeneXpert MTB/ RIF …
Constantin Iavorschi, Stela Kulcitkaia, Igor Ivanes, Nadejda Pisarenco
Pediatric tuberculosis (TB) presents unique diagnostic challenges due to various factors, including the low sensitivity of sputum examination, difficulties in obtaining samples, and the presence of paucibacillary forms of the disease. This retrospective-descriptive study aimed to…
Babafemi EO, Cherian BP, Ouma B, Mogoko GM
Background Rapid and accurate diagnosis of paediatric tuberculosis (TB) is key to manage the disease and to control and prevent its transmission. Collection of quality sputum samples without invasion methods from paediatrics (age Methods We conducted a systematic review and meta-…
Maria Eugênia Julio, Alexandra Monteiro, Mônica de Cássia Firmida, Diego Rodrigues Tavares, Ana Josiele Ferreira Coutinho
Pulmonary tuberculosis in childhood is difficult diagnosis taking into account the difficulty of microbiological confirmation, being diagnosis based on the presence of clinical signs, radiological alterations, history of contact with a bacilliferous adult, and interpretation of t…
Tulane University
Pediatric tuberculosis (TB) continues to pose diagnostic challenges in low- and middle-income countries with high rates of TB disease, due to the well-described impact of paucibacillary disease in children, and current TB culture and polymerase-chain reaction tests are of limited…
Sayyahfar S, Davoodzadeh F, Hoseini R, Rahimzadeh N, Otukesh H
…till a valuable diagnostic tool with high accuracy rate for diagnosis of LTBI in children candidates for renal transplantation and can still be used as an accurate test for screening Mycobacterium TB infection.
Shrinivasa B. Marinaik, Sriram Selvaraju, R. Srinivasan, Krishnamoorthy, Sunil Kumar Raina, et al.
Background: About one-fifth of the global gap in TB diagnosis was contributed by India which translates to roughly over half a million cases. Meanwhile the National tuberculosis elimination programme has made coordinated efforts to involve public and private health providers in a…
Sharma S, Shulania A, Achra A, Jeram H, Kansra S, et al.
… and Mycobacteria Growth Indicator Tube (MGIT™) culture for diagnosis of pediatric pulmonary tuberculosis from gastric aspirate (GA) samples and to compare Xpert assay and ZN staining with MGIT rapid liquid culture. Materials and methods GA samples from 210 nonexpectorating child…
Krunal Patel, Kinjal Patel, Pooja Gandhi, Bhavini Rathwa, Dipak M. Nakum
Introduction: Tuberculosis is a chronic infectious disease caused by predominantly Mycobacterium tubercle bacilli. Pediatric tuberculosis is among the top 10 causes of death in children. India accounts for one fourth of the global tuberculosis burden, standing one among the thirt…
Isabelle Munyangaju, Andreas Jahnen, Ridwaan Esmail, Benedita José, Jacinta Adrigwe, et al.
**BACKGROUND:** Pediatric tuberculosis diagnosis relies heavily on imaging, yet access, equipment standards, and dose monitoring differ widely across health systems. Evidence describing how these contextual factors influence imaging use and radiation exposure in children remains …
Aybüke Akaslan Kara, Kamile Ötiken Arıkan, Elif Böncüoğlu, Elif Kıymet, Şahika Şahinkaya, et al.
…we aimed to evaluate the approaches and knowledge levels of pediatric infectious diseases research workers and pediatricians in the diagnosis and treatment of tuberculosis under the guidelines updated by the Ministry of Health in 2019. Method: This survey is a descriptive study a…
Pierre-Louis MH, Rouzier V, Rivera V, Systrom HK, Julma P, et al.
… (Xpert) assay is a useful adjunct to culture for the rapid diagnosis of tuberculosis (TB) using gastric lavage aspirates (GLAs) in children aged Methods We reviewed the yield from diagnostic modalities in children suspected of having TB followed at an infectious disease research…
Emad Siddiqui, Tooba Siddiqui, Abdus Salam Khan
Abstract Background Tuberculosis (TB), a preventable airborne infectious disease, early detection is essential to improve health outcomes. Extent of childhood tuberculosis is unknown and is estimated to be around 6% of all incidences. Diagnosis of pediatric tuberculosis is always…
Olesya Pankratova
Tuberculosis is one of the 10 leading causes of death in the world. According to the WHO global strategy, one of the health targets of the Sustainable Development Goals is to end the tuberculosis epidemic by 2030. The article summarizes the basic theoretical data from various pro…
Francesca Montagnani, PhD, MD
…T, Cellestis Limited, Carnegie, Victoria, Australia) in the diagnosis of tuberculosis (TB - active or latent) in pediatric subjects (0 and 17 year)s recently exposed to infection (indicated as "contacts") or with clinical suspicion of active TB, and to compare the results obtaine…
Tran ST, Le HT, Dang HTT, Dao TM, Van Nguyen L, et al.
Diagnosis of pediatric tuberculosis is notoriously difficult. We investigated the additional yield of blood culture in hospitalized children in Vietnam. Among 554 enrolled clinically suspected patients, an additional 6 cases were diagnosed, while the incremental cost per case was…
Dutta NK, Tornheim JA, Fukutani KF, Paradkar M, Tiburcio RT, et al.
Pediatric tuberculosis (TB) remains a major global health problem. Improved pediatric diagnostics using readily available biosources are urgently needed. We used liquid chromatography-mass spectrometry to analyze plasma metabolite profiles of Indian children with active TB (n = 1…
Villarreal EG, Ramos-Barrera E, Estrada-Mendizabal RJ, Treviño-Valdez PD, Tamez-Rivera O
…d Analyzing the epidemiology and clinical manifestations of pediatric tuberculosis in endemic regions is crucial to meet the goal of ending tuberculosis. The objective was to assess the various clinical scenarios of tuberculosis in a large pediatric cohort in Mexico. Methods This…
Gagni Coulibaly, Fah Gaoussou Traoré, Bassirou Diarra, Aminata Maïga
<h3>Background</h3> The diagnosis of childhood tuberculosis is still a challenge in the world because children are generally paucibacillary moreover obtaining sputum is very difficult. Most of the existing diagnostic tests for tuberculosis are based on sputum sampling in symptoma…
John Cherry
… Summary This preprint examines the time from completion of tuberculosis preventive therapy to later TB diagnosis among people living with HIV on ART in Eastern Uganda. The study uses routine program data from three TASO Centres of Excellence in Mbale, Soroti, and Tororo and incl…
John Cherry
… Summary This preprint examines the time from completion of tuberculosis preventive therapy to later TB diagnosis among people living with HIV on ART in Eastern Uganda. The study uses routine program data from three TASO Centres of Excellence in Mbale, Soroti, and Tororo and incl…
Gupta N, Kashyap B, Dewan P, Hyanki P, Singh NP
Aim and objectives The paucibacillary nature of pediatric tuberculosis (TB) makes diagnosis difficult. The aim of the study was to correlate the clinical spectrum of pediatric TB with microbiological diagnosis. Materials and methods Specimens from clinically suspected pediatric T…
Christian Wejse
… al.Point of care Xpert MTB/RIF versus smear microscopy for tuberculosis diagnosis in southern African primary care clinics: a multicentre economic evaluation.Lancet Glob Health. 2019; 7: e798-e807Summary Full Text Full Text PDF PubMed Scopus (27) Google Scholar present a previou…