Showing 76–100 of 107 documents
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David S.C. Hui, Chi Chiu Leung
Respiratory tract infections (RTI), such as community-acquired pneumonia (CAP) and tuberculosis (TB), are important causes of morbidity and mortality. The ongoing outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) infection and epidemic waves of avian influenza …
Kavitha Saravu, Madhukar Pai
Drug-resistant tuberculosis (DR-TB) continues to be a global health crisis. In 2017, an estimated 558 000 people had rifampicin-resistant TB (RR-TB), and 82% of them had multidrug-resistant TB (MDR-TB); 3.5% of new TB cases and 18% of previously treated cases had MDR/RR-TB. A qua…
Supriya Dhakne
Introduction: Multidrug‑resistant tuberculosis (MDR‑TB) has created a significant health problem in most of the countries, and it is an obstacle to effective TB control. Aims and Objectives: The study aims to study the prevalence of MDR‑TB among new cases, retreatment cases and t…
Harichander S, Bangalee V, Oosthuizen F
Background Children represent a particularly vulnerable demographic in the context of drug-resistant (DR) tuberculosis (TB) due to their increased likelihood of close contact with adults diagnosed with the disease. Approximately 25 000-30 000 children develop DR-TB annually. Whil…
Shah I, Gandhi S, Shetty NS
Bedaquiline and delamanid used to treat extensively drug-resistant tuberculosis are known to cause prolonged QTc. Two children with extensively drug-resistant tuberculosis were put on bedaquiline and delamanid and had prolonged QTc on the Bazett formula but normal QTc by the Frid…
Human Sciences Research Council
A community based drug resistant tuberculosis (DR-TB) program has been incrementally implemented in Khayelitsha, a high HIV and TB burden community in South Africa. We investigated loss from treatment (LFT), and post treatment outcomes of DR-TB patients in this setting. LFT, defi…
Azfar A. Ishaqui, Salman A. Ahmad, Shoaib Alam, Narendar Kumar, Javeria Farooq, et al.
Objectives: Tuberculosis (TB) continues to drive infectious mortality worldwide. The study characterized the evolution of drug-susceptible TB (DS-TB), multidrug-resistant TB (MDR-TB), and extensively drug-resistant TB (XDR-TB) in 30 WHO high-burden countries, linking current patt…
Adwait Suhas Bendre, Onella Fernandes, Mahvish Naser Shaikh, Ira Shah
Abstract Introduction Central nervous system tuberculosis (CNS-TB) commonly presents with tuberculous meningitis and may be complicated by hydrocephalus, usually early in the disease course. Late-onset hydrocephalus occurring after prolonged anti-tubercular therapy (ATT) is rare.…
Senlin Zhan, Kaihua Pang, Xiang Li, Liangzi Yang, Yuxiang Wang, et al.
<title>Abstract</title> Background Linezolid (LZD), a pivotal agent in the treatment of tuberculosis (TB), is constrained by its adverse event (AE) profile. Contezolid (CZD), an innovative oxazolidinone derivative approved in China in 2021 for complicated skin and soft tissue inf…
I. Zhanybekov
The article presents a comparative analysis of the medical, social and clinical and epidemiological characteristics of patients with tuberculosis, the causative agent of which has broad (XDR-TB) and pre-wide (pre-XDR-TB) drug resistance in the Kyrgyz Republic. The study included …
Anjali Krishnan P, Praveen Kumar N, Raghul Raj S, Ankit Kumar Bharti S, J. A. Pulatov
Background: Drug-resistant tuberculosis (DR-TB) remains a major global health challenge. Treatment for multidrug-resistant and rifampicin-resistant TB (MDR/RR-TB) is often prolonged, toxic, and burdensome, contributing to poor outcomes. Despite improvements, MDR/RR-TB still has a…
M. Santhana Kumar, M. Arhoul Rennies, Rajeshwari Sivaraj, R Sneha, S. Vennila
Background: Tuberculosis (TB) remains a major global public health challenge, presenting primarily as pulmonary TB (PTB) or, less commonly, as extra pulmonary TB (EPTB). Objectives: This study aimed to: (1) document the clinical symptoms of PTB and EPTB; (2) identify associated r…
Odete Bambi Receado, Paulo Ney Solary, Emanuel Catumbela, Carlos Alberto Pinto de Sousa
Introduction Multidrug-Resistant Pulmonary Tuberculosis (MDR-TB) represents a serious public health problem, hindering disease control and increasing morbidity and mortality. This study aimed to identify risk factors associated with MDR-TB in patients over 15 years old at the San…
Zulfiya Haybullo Tilloeva, Roberta Horth, A. S. Mirzoev, Rajabali Sharifov, Dilyara Nabirova, et al.
Abstract Background Multidrug resistant TB (MDR-TB) incidence is increasing in Central Asia, especially in Tajikistan, which is among the top 30 high-burden countries. Delays in treatment initiation are associated with increased transmission and poor health outcomes. In Dushanbe,…
Prof Tubonye Harry, Dimie Ogoina, Dr Peter Nwakile, P. Ikuabe, Mr Jonathan Nanakede, et al.
shorter regimens, and 7 (13,2%) -with longer regimens (p < 0.05).Treatment outcomes were not evaluated in 6 patients (10,3%) who had started on shorter regimens and in 9 (17.0%)-on longer regimens (p > 0.05).One patient (1,7%) in the short regimen group died of TB and 2 (3.8%) in…
Sarika Gupta, Mala Kumar, S. N. Singh, Shalini Tripathi, Sakshi Singh, et al.
Abstract Congenital tuberculosis (TB) is an uncommon yet severe form of TB, where the diagnosis and management are challenging due to nonspecific clinical manifestations. Pre-extensively drug-resistant tuberculosis (Pre-XDR TB) shows resistance to at least one fluoroquinolone alo…
Boris Jolly Lokoti, Alain Farra, Alexandre Manirakiza, Herve Gando, Doriane Ouanibilo, et al.
Multidrug-resistant tuberculosis (MDR-TB) poses a major challenge in the Central African Republic (CAR), as the high incidence of tuberculosis and resistance rates to anti-tuberculosis drugs compromise efforts to manage MDR/RR-TB patients. This study evaluates the efficacy of bed…
A. S. (Abdullaeva) Sh
A third of the world's population is infected with Mycobacterium tuberculosis (MTB) and more than 9 million cases of tuberculosis (TB) are diagnosed annually, resulting in almost 2 million deaths each year (WHO., 2015). TB accounts for more than a quarter of all preventable death…
Pratik Kumar, Amardeepak Toppo, Sagarika Pradhan
Abstract Background: Studies on resistance pattern and profile of patients with drug resistant tuberculosis (DRTB) are valuable as they provide insights into what are the rates of DRTB locally. Based on these data, treatment may be optimized. They also help in prevention of sprea…
Yani Jane Sugiri, Rezki Tantular, Silvy Amalia Falyani, Uray Riki Arif Maulana
Introduction. Mycobacterium tuberculosis (MTB) is continually evolving in order to resist treatment. This has resulted in drug-resistant tuberculosis, which has a greater rate of therapy failure and mortality, as well as the necessity for other ways of disease transmission preven…
Anita Mesić, Ine I. Decuyper, Sadiqqullah Ishaq, Taiba Azizi, Fazal Hadi Ziamal, et al.
Clinical trials, evaluating 9-month/7-drug and 6-month/4-drug all-oral rifampicin-resistant tuberculosis (RR-TB) treatment regimens showed that these are at least as effective and safer than previously used longer and injectable-containing regimens [1–4]. Findings directly inform…
Malik Zohaib Ali, Taru S. Dutt, Amy L. MacNeill, Amanda Walz, Johnathan Patterson, et al.
The Nix-TB clinical trial evaluated a new 6-month regimen containing three-oral-drugs; bedaquiline (B), pretomanid (Pa) and linezolid (L) (BPaL regimen) for treatment of tuberculosis (TB). This regimen achieved remarkable results as almost 90% of the multidrug resistant (MDR) or …
Giller Db, В.В. Короев, O.Sh. Kesaev, G. V. Shcherbakova, А. А. Попова, et al.
Treatment of cavernous or fibro-cavernous pulmonary ТВ, especially multidrug-resistant (MDR-TB) or extensively drug resistant TB (XDR-TB), in children is a huge challenge. At the same time, the incidence of drug-resistant TB is growing throughout the world year after year. We ana…
Mahaman Laouali Harouna Amadou, Ibrahim Maman Lawan, Abdoulaye Ousmane, Abdoul Kadir Ibrahim Mamadou, AMADOU, Oumarou, et al.
Aim of study: To describe the clinical, therapeutic and evolutionary profile of patients followed for rifampicin-resistant pulmonary tuberculosis (RR-TB) at the Regional Hospital Centre (RHC) of Maradi (Niger) from 2014 to 2018. Methods: We conducted a retrospective and descripti…
Olena Ivanova, Dragoș Băiceanu, Abhishek Bakuli, M. Vogel, Cristina Popa, et al.
Abstract Background Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) patients are likely to suffer from TB-related morbidity, social and economic consequences during and beyond anti-TB treatment. The aim of this study is to describe clinical and so…