Showing 76–100 of 200 documents
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Tembo BP, Malangu NG
…evalence and factors associated with the prevalence of multidrug/rifampicin-resistant tuberculosis among suspected drug resistant tuberculosis patients in Botswana. Methods A retrospective review of medical records of suspected drug resistant tuberculosis patients receiving care …
Dagli N, Haque M, Kumar S
…ovides a comprehensive overview of the current landscape in drug-resistant tuberculosis research. An extensive electronic search was conducted on PubMed and Scopus databases to identify clinical trials related to drug-resistant tuberculosis. Network analysis and visualization wer…
Sharma D, Bisht D, Khan AU
… the deadliest human pathogen of the tuberculosis diseases. Drug resistance leads to emergence of multidrug-resistant and extremely drug resistant strains of M. tuberculosis . Apart from principal targets of resistance, many explanations have been proposed for drug resistance but…
Yannan Xu, Sixuan Liu, Jiaxiong Zheng, Jianxiong Lin, Liwei Gi, et al.
**BACKGROUND:** The situation of drug-resistant tuberculosis in China remains serious and complex. The majority of the study data are still derived from the 2,207 national survey of drug-resistant tuberculosis. In this study, we aimed to comprehensively characterize the prevalenc…
Pei S, Song Z, Yang W, He W, Ou X, et al.
…erium tuberculosis complex (MTBC) mutations associated with drug resistance in 2021. However, country-specific issues might lead to arising complex and additional drug-resistant mutations. We aimed to fully reflect the characteristics of drug resistance mutations in China. Method…
Theron G, Limberis J, Venter R, Smith L, Pietersen E, et al.
A burgeoning epidemic of drug-resistant tuberculosis (TB) threatens to derail global control efforts. Although the mechanisms remain poorly clarified, drug-resistant strains are widely believed to be less infectious than drug-susceptible strains. Consequently, we hypothesized tha…
Téllez-Navarrete NA, Ramon-Luing LA, Muñoz-Torrico M, Preciado-García M, Medina-Quero K, et al.
…ing is required to maintain Treg. Methods A blood sample of drug-susceptible (DS-TB) and drug-resistant tuberculosis (DR-TB) patients was obtained before (basal) and after 2 and 6 months of anti-TB therapy. Expression of TNF, TNFR1, and TNFR2 (transmembrane form, tm) on cTreg, uT…
Saad Ahmed Jamal
…ases, 1.4 million deaths and nearly half a million cases of drug-resistant TB, in 2019. The need of the hour is to prevent the rise of drug resistance in TB. The rise in drug resistance can be mainly attributed to failure to adhere to treatment regimens. Recent studies show that …
He G, Zheng Q, Shi J, Wu L, Huang B, et al.
…ncing (WGS), has greatly facilitated the early diagnosis of drug-resistant tuberculosis patients. Nonetheless, the interpretation of results from various types of mutations in drug-resistant-associated genes has become the primary challenge in the field of molecular drug-resistan…
Maryam Gul, Sajid Ali, Abdul Rehman, Muhammad Qasim, Roomana Ali, et al.
**BACKGROUND:** Resistance to first-line anti-tuberculosis drugs inrepresents a significant public health challenge, particularly in high-burden tuberculosis (TB) settings such as Pakistan, where multidrug-resistant (MDR) forms further complicate disease control efforts. Drug res…
Kumar V, Jorwal P, Soneja M, Sinha S, Nischal N, et al.
Background Early diagnosis and treatment of drug-resistant tuberculosis (TB) is crucial to halt the spread of drug resistance in the community. Aim The aim of the study was to compare rapid diagnostic tests (GeneXpert and line probe assay, LPA) with conventional liquid culture fo…
Mekonnen D, Munshea A, Nibret E, Adnew B, Getachew H, et al.
Introduction Drug resistance (DR) in Mycobacterium tuberculosis complex (MTBC) is mainly associated with certain lineages and varies across regions and countries. The Beijing genotype is the leading resistant lineage in Asia and western countries. M. tuberculosis (Mtb) (sub) line…
Liebenberg D, Gordhan BG, Kana BD
Drug resistant tuberculosis contributes significantly to the global burden of antimicrobial resistance, often consuming a large proportion of the healthcare budget and associated resources in many endemic countries. The rapid emergence of resistance to newer tuberculosis therapie…
Li S, Chen W, Feng M, Liu Y, Wang F
…by the disease have been decreasing. However, the number of drug-resistant tuberculosis patients is increasing rapidly year by year. Here, a total of 380 Mycobacterium tuberculosis (MTB)-positive formalin-fixed and paraffin-embedded tissue (FFPE) specimens diagnosed in the Depart…
Okumu Albert, Odeny Lazarus, Ochieng John Benjamin, Odhiambo Ben, Sitati Ruth, et al.
…treatment. Molecular techniques enable characterization and drug resistance profiling, this study sought to determine NTM prevalence, circulating species, and distribution factors among presumptive multidrug-resistant tuberculosis (MDR-TB) patients in western Kenya. **METHOD:** …
Gygli SM, Keller PM, Ballif M, Blöchliger N, Hömke R, et al.
Whole-genome sequencing allows rapid detection of drug-resistant Mycobacterium tuberculosis isolates. However, the availability of high-quality data linking quantitative phenotypic drug susceptibility testing (DST) and genomic data have thus far been limited. We determined drug r…
Baijayantimala Mishra, PrasantaRaghab Mohapatra
Multidrug-resistant tuberculosis (MDR-TB) is one of the most pressing and problematic challenges being faced globally. The dynamic transmission microsimulation model of TB in India estimates that 42 per cent of the new MDR cases are spread by transmission and this proportion cont…
Deepshikha Singh, Vikram Jeet Singh, Subhankar P. Mandal, Karen N. DSouza, B. R. Prashantha Kumar, et al.
Abstract: Multi drug-resistant or extensive drug resistance Mycobacterium tuberculosis poses numerous challenges for health care workers and for public health authorities. Treating multidrug resistant or extensive drug resistance tuberculosis continues to be a difficult task, as …
Truden S, Sodja E, Žolnir-Dovč M
…cterium tuberculosis (MT) complex with mutations conferring resistance to isoniazid (INH), ethionamide (ETH), fluoroquinolone (FQ), and second-line injectable drugs (SLIDs). The aim of our study was to evaluate the performance of the Xpert MTB/XDR rapid molecular assay on rifampi…
Wu Q, Wang M, Zhang Y, Wang W, Ye TF, et al.
…cerns, while the comprehensive evaluations of DM status and drug resistance in TB patients are still lacking. Methods All details of TB cases were collected from drug resistance monitoring sentinels in Zhejiang province. Fisher's exact test or Pearson chi-square test (χ 2 ) was u…
Li X, Sheng L, Tu J, Lou L
…he bactericidal effect of nano silver and anti-tuberculosis drugs on drug-resistant Mycobacterium tuberculosis . Solid-state drug sensitivity tests with streptomycin (SM), isoniazid (INH), RIF, EMB, kanamycin (km), and ofloxacin (ofx) were carried out on H37Rv and different clini…
Fang WJ, Tang SN, Liang RY, Zheng QT, Yao DQ, et al.
…he two most promising imaging signs in differentiating multidrug-resistant (MDR)-pulmonary tuberculosis (PTB) from drug-sensitive (DS)-PTB. However, there have been concerns that literature described radiological feature differences between DS-PTB and MDR-PTB were confounded by t…
Jiang F, Xu C, Wang Y, Xu Q
…tomography based radiomics in the differential diagnosis of drug-sensitive and drug-resistant pulmonary tuberculosis. Methods The clinical and computed tomography image data of 177 patients who were diagnosed with pulmonary tuberculosis through sputum culture and completed drug-s…
Wang Y, Xu H, Li Y, Gao H, Zhang Z, et al.
Drug-resistant tuberculosis (DR-TB), particularly multidrug-resistant tuberculosis (MDR-TB), has been identified as a major challenge for effective TB control. For rapid detection and proper treatment, molecular assays based on the identification of mutations in genes associated …
Sylverken AA, Kwarteng A, Twumasi-Ankrah S, Owusu M, Arthur RA, et al.
Resistance to Tuberculosis drugs has become a major threat to the control of tuberculosis (TB) globally. We conducted the first nation-wide drug resistance survey to investigate the level and pattern of resistance to first-line TB drugs among newly and previously treated sputum s…