Showing 76–100 of 200 documents
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Ruiz L, Maya MA, Rueda ZV, López L, Vélez LA
…To describe the epidemiology, clinical features, diagnosis, resistance patterns, tuberculosis drug effects and mortality in co-infected patients. Materials and methods Retrospective study based on the review of medical records of hospitalized co-infected adults in a university ho…
Amit Budhori, Abhishek Tiwari, Varsha Tiwari, Manish Kumar
… the world as per the WHO. It has emerged as new threat and drug resistance strains of Mycobacterium are emerging throws a challenge to human’s health like Covid-19 in current scenario. TB is now come in the form of bone TB, which is very difficult to diagnosis due to very slow-g…
Gao W, Yang C, Wang T, Guo Y, Zeng Y
…were 82.4, 88.2, 94.1, and 94.1%, respectively. Analysis of drug resistance based on tNGS results indicated that 10 of 93 TB patients (10.75%) had potential drug resistance. Conclusion Targeted next-generation sequencing achieved higher accuracy than other established diagnostic …
Dhiman A, Kumar C, Mishra SK, Sikri K, Datta I, et al.
…gnosis and treatment. Further, the increasing prevalence of drug-resistant TB highlights the urgent need to develop novel inhibitors against both drug-susceptible and drug-resistant forms of disease. Malate synthase (MS), an enzyme of the glyoxylate pathway, plays a vital role in…
Mailing Huang, Yujin Wang, Tao Chen, Yu Lu, Naihui Chu, et al.
… 0.008). Blood concentrations were higher than CSF for both drugs at all time points. No serious drug-related adverse events occurred. Contezolid effectively penetrates the blood-CSF barrier in TBM patients, achieving CSF concentrations above the MIC for Mtb. Although its CSF exp…
Vipin Kumar, Manju Bala, Anil Kanga, Neha Gautam
…y automated cartridge-based real-time PCR to detect MTB and resistance to rifampicin within two hours using three specific primers and five unique molecular probes to target the rpoB gene. This study was done to detect RR-TB cases and frequency of missing probes, which target mut…
Seipone ID, Singh R, Patel VB, Singh A, Gordon ML, et al.
…sociated meningitides, we assessed HIV-1 viral load levels, drug resistance patterns in antiretroviral therapy (ART)-experienced patients with persistent viremia and soluble immunological analytes in peripheral blood and cerebrospinal fluid (CSF) of HIV-1 infected patients with T…
Pranger AD, van der Werf TS, Kosterink JGW, Alffenaar JWC
The inability to use powerful antituberculosis drugs in an increasing number of patients seems to be the biggest threat towards global tuberculosis (TB) elimination. Simplified, shorter and preferably less toxic drug regimens are being investigated for pulmonary TB to counteract …
Walzl G, McNerney R, du Plessis N, Bates M, McHugh TD, et al.
…se worldwide. Early and accurate diagnosis and detection of drug-sensitive and drug-resistant tuberculosis is essential for achieving global tuberculosis control. Despite the introduction of the Xpert MTB/RIF assay as the first-line rapid tuberculosis diagnostic test, the gap bet…
Shireen Yan Ling Tan, Jamie Bee Xian Tan, Dorothy Hui Lin Ng
… an extremely difficult pathogen to treat, requiring a multidrug combination regimen for protracted durations,[11] with disappointingly high rates of recurrence.[4,5,12,13] The choice of antibiotics is complicated by the high rates of intrinsic resistance in MABC to many antibiot…
Md. Masud Karim, Mohammad Ashik Imran Khan, Farzana Banu, Md Zahirul Islam Shakil, Golam Sarwar Liaquat Hossain Bhuiyan, et al.
…osis (EPTB) is a growing public health concern, and data on drug resistance in EPTB are limited. Objective: To detect Mycobacterium Tuberculosis in extrapulmonary specimens and to find out identity the pattern of drug sensitivity among extrapulmonary specimens Methods: This cross…
Joanna Drozd-Sokołowska, Gloria Tridello, Inge Verheggen, Musa Karakukcu, Nour Ben Abdeljelil, et al.
…as compared to pulmonary TB. Five (22%) of 23 patients with drug-susceptibility testing performed, were resistant to at least one anti-TB drug. Treatment success was achieved in 38/50 (76%) of treated patients. One-year overall survival reached 75.7% and the 1-year cumulative inc…
Gemechu J, Gebremichael B, Tesfaye T, Seyum A, Erkalo D
…were anemia (AHR = 3.6; 95%CI: 1.39-9.31), fair or poor ART drug adherence (AHR = 2.9; 95%CI = 1.15-7.43), extrapulmonary TB (AHR = 3.9; 95%CI: 1.34-11.45) and TB drug resistance (AHR = 5.7; 95%CI: 2.07-15.96). Conclusion Mortality rate of TB/HIV co-infected children in selected …
Shalabh Malik, Puneeta Singh, Vandana Lal
…jectives: The aim and objectives of this study is to assess drug resistance pattern of Streptococcus pneumoniae in Dr Lal Path Labs, Delhi. We did retrospective study from January 2016 to December 2017 on 86 isolates of Streptococcus pneumoniae.
 Materials and Methods: At st…
Admassu W, Ayelign B, Abebe G, Tadesse M
…round Rapid diagnosis of tuberculosis (TB) and detection of drug resistance are very important for timely and appropriate management of patients. Xpert MTB/RIF assay is approved for use in TB and rifampicin-resistance diagnosis. However, data are limited on the impact of Xpert MT…
Reis AJ, Diniz JLCG, Silva ABS, Silveira J, Basso R, et al.
…h the performance of the Xpert MTB/RIF (Xpert) platform and drug resistance profiles. Methodology. We evaluated the performance of the Xpert platform. Samples that tested positive on the BACTEC MGIT 320 (MGIT320) platform were submitted for genotyping and drug susceptibility test…
Saurabh Jain, Ramesh Agrawal
…s incidence in India is 2.74 million including 0.13 million drug resistant cases. According to WHO 0.41 million death in India due to tuberculosis in 2017. Sputum smear microscopy is facing variable sensitivity issue particularly in patients with sputum smear-negative and/or extr…
Balikçi A, Erbakan M, Babalik A
…s sent to our laboratory over five years and the growth and resistance rates in two different (solid and liquid) cultures and compare them with the data from Türkiye and the world. Materials and methods A total of 62.456 clinic samples were accepted in the microbiology laboratory…
Ashima Jamwal, Anjali Swami, Ankita Mohanty, Sujata Baveja
…the availability of rapid diagnostics, conventional culture Drug Susceptibility Testing (DST) is still considered the gold standard in diagnosing TB. Aim: To assess the diagnostic accuracy of culture DST which is considered the gold standard. Materials and Methods: This cross-sec…
Sharma SK, Mohan A, Kohli M
…r diagnostic testing possible. With the advent of universal drug-susceptibility testing, a rapid diagnosis of drug-resistance is now possible in EPTB. Drug-susceptible EPTB usually responds well to first-line anti-TB treatment; TB meningitis, bone and joint TB and lymph node TB r…
Pratyaksha Singh, Saurabh Kumar Bhati, Monika Jain, Rashmi Prabha Singh, Jayaraman Muthukumaran, et al.
…ne of the world's most severe pathogens due to growing multidrug resistance (MDR) and extensively drug resistance (XDR), rendering treatment medications useless. GpgP was chosen as the promising drug target protein in this study because it is primarily involved in the catalysis o…
Bella Devaleenal Daniel, Leeberk Raja Inbaraj, D. Tumu
…t article by Sotgiu et al. highlighted shortages in anti-TB drug supply, its impact on the TB treatment and implications for National TB programmes (NTPs).1 The authors raised various concerns, in-cluding unfavourable treatment outcomes, drug tox-icities, resistance and catastrop…
Kusum Sharma, Megha Sharma, Ritu Shree, Neeraj Singla, Nalini Gupta, et al.
… aid in TB elimination efforts by establishing diagnosis of drug-resistant extrapulmonary tuberculosis (EPTB). 600 EPTB samples (125 microbiologically-confirmed, 275 clinically-suspected and 200 controls) processed between January 2019 and June 2023 were subjected to Truenat MTB …
Boudriiya Tamer, El Mamoune Mostaine, Mejdoub Sara, Souly Karim, Mimoun Zouhdi
…ificant global health concern, with increasing incidence of drug-resistant strains posing challenges to effective treatment. We present a case of rifampicin-resistant tuberculous meningitis in an immunocompetent child, highlighting the severity and complexity of tuberculosis in p…
Saurabh Kumar Singh, Mitali Gupta, Pratibha Yadav
…logical methods. Treatment requires the combination of four drugs (Rifampicin, Isoniazid, ethambutol and pyrazinamide) for a minimum of six months duration. In case of drug resistant tuberculosis reserve drugs are used for the extended period.