Showing 76–100 of 200 documents
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Tarun Narang, Divya Kamat, Vishal Thakur, Mallika Lavania, Itu Singh, et al.
…dia. It is believed that bacilli persisting even after multidrug therapy can cause relapse; recently, however, drug resistance as a cause for recurrences and chronic erythema nodosum leprosum (ENL) has been speculated. AIM: To study drug-resistance patterns in cases of leprosy re…
Wei Wang, Yuxin Gao, Yong Gao, Tuantuan Li, Yan Liu, et al.
**OBJECTIVE:** This study aimed to analyze drug resistance patterns and inpatient medication utilization among drug-resistant tuberculosis (DR-TB) patients in Fuyang City (2021-2023), and to identify factors associated with unsuccessful treatment outcomes in multidrug-resistant t…
Christoph Lange, Keertan Dheda, Dumitru Chesov, Anna M. Mandalakas, Zarir Udwadia, et al.
…search and development and in implementation, to reduce the drug-resistant tuberculosis epidemic.1Lange C Dheda K Chesov D Mandalakas AM Udwadia Z Horsburgh Jr, CR Management of drug-resistant tuberculosis.Lancet. 2019; 394: 953-966Summary Full Text Full Text PDF PubMed Scopus (1…
Yenew B, Kebede A, Alemu A, Diriba G, Mehammed Z, et al.
Background The emergence of drug-resistant tuberculosis (DR-TB) has been a major obstacle to global tuberculosis control programs, especially in developing countries, including Ethiopia. This study investigated drug resistance patterns and associated mutations of Mycobacterium tu…
Getu Diriba, Hilina Mollalign, Abyot Meaza, Melak Getu, Betselot Zerihun, et al.
**BACKGROUND:** Rapid and accurate detection of extensively drug-resistant tuberculosis is crucial for effective intervention. Next-generation sequencing technologies have been recommended to rapidly and accurately detect resistance to second-line anti-TB drugs. We deployed whole…
Garg RK, Rizvi I, Malhotra HS, Uniyal R, Kumar N
Introduction Drug-resistant tuberculous meningitis has been reported worldwide. Isoniazid mono-resistance is the most frequent cause of drug-resistant tuberculous meningitis, a life-threatening disease. Extensive drug-resistant tuberculous meningitis has also been reported in som…
Hailemariam TG, Ayele A, Gelanew T, Atnafu A, Brennan M, et al.
…jor global health challenge, particularly due to increasing drug resistance. Beyond the well-characterized mutations, the mechanisms involved in driving resistance appear to be more complex. This study investigated the differential gene expression of Ethiopian drug-resistant Mtb …
Ansarin K, Sahebi L
Background and objectives Drug-resistant tuberculosis (Tb) is a major public health issue across the world. Therefore, it is crucial to determine its pattern in different regions of the world. The aim of this study was to review the prevalence of drug resistant TB in the west and…
Li M, Deng B, Huang Y, Li Q, Han J, et al.
To investigate the status of the drug-resistant tuberculosis (DR-TB) among children in Sichuan, and to find out the risk factors and high-risk population related to drug resistance among children. The clinical data of tuberculosis patients ≤14 years old with culture-confirmed tub…
Ncha R, Variava E, Otwombe K, Kawonga M, Martinson NA
…SCC) and factors predictive of TTSCC in patients with multi-drug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) in the North-West Province. Methods A retrospective cohort study, abstracting patient demographic and clinical data, laboratory re…
Keertan Dheda, MD/PhD
Resistance to anti-tuberculosis drugs is a continually growing problem. Multidrug-resistant tuberculosis (MDRTB) is resistance to at least rifampicin and isoniazid, and extensively drug-resistant TB is additional resistance to a fluoroquinolone and a second injectable line drug. …
Ulan Kozhamkulov, Zhannur Abilova, Ainur Akhmetova, Saule Rakhimova, Nuray Tynyshtykbayeva, et al.
…khstan is among the countries with a high incidence rate of drug-resistant TB, especially MDR TB. This study collected 161 drug-resistant <italic>M.tuberculosis</italic> and selected 7 XDR and 42 pre-XDR isolates for whole genome sequencing (WGS). Drug susceptibility testing of <…
E. E. Lesnik, S. Ginda
…e main parameters of cellular, humoral immunity and natural resistance in tuberculosis patients with primary and acquired multiple drug resistance; to study the correlation of these parameters with clinical and radiological manifestations. Subjects and Methods. A prospective stud…
Udhaya Kumar S, Saleem A, Thirumal Kumar D, Anu Preethi V, Younes S, et al.
Background and aim The persistence of extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (MTB) continue to pose a significant challenge to the treatment and control of tuberculosis infections worldwide. XDR-MTB strains exhibit resistance against first-line ant…
Chen S, Shang Y, Zheng J, Huo F, Xue Y, et al.
Objectives The co-resistance between bedaquiline and clofazimine raises significant concerns, as they are commonly co-administered as core drugs in drug-resistant TB regimens. The present study aimed to monitor drug resistance-associated gene mutations and the phenotypic change i…
Hira Ashfaq, Ayesha Humayun, Muhammad Ahmad Naseem, Sarmad Wahaj Siddiqui, Asifa Kamal, et al.
**BACKGROUND:** Globally, the prevalence of drug-resistant (DR-TB) tuberculosis is rising, and Pakistan is currently one of the nations with the highest burden. It is imperative to track changes in the prevalence of DR-TB, particularly the extensively drug-resistant (XDR-TB) tube…
Rajeev Ranjan, Venkata Siva Reddy Devireddy
Drug resistant tuberculosis is a major public health concern, since the causative agent Mycobacterium tuberculosis is resistant to the most effective drugs against tuberculosis treatment ie., rifampicin and isoniazid. Globally, it accounts 4.6 percent of the patients with tubercu…
Abbas Abel Anzaku
Abstract Background: This study evaluated the prevalence of drug resistant tuberculosis infection among suspected tuberculosis patients attending Asokoro District Hospital (ADH), Abuja, Nigeria. Methods: A total of 301 AFB+/- sputum specimens from suspected TB patients were colle…
Chawla GK, Garg K, Kaur K, Chopra V, Suri R
Background Drug resistant tuberculosis (DR-TB), particularly multidrug resistance (MDR-TB) and extensive drug resistance (XDR-TB) pose a serious threat to public health. This study aimed to identify drug resistance in pulmonary tuberculosis patients and to see their association w…
Heyckendorf J, Andres S, Köser CU, Olaru ID, Schön T, et al.
Rapid and accurate drug susceptibility testing (DST) is essential for the treatment of multi- and extensively drug-resistant tuberculosis (M/XDR-TB). We compared the utility of genotypic DST assays with phenotypic DST (pDST) using Bactec 960 MGIT or Löwenstein-Jensen to construct…
Bharath Kathi, Vubbara Anupama, Attili Sasi Kiran, Balaji Patamsetty, Gorthi Aruna, et al.
Background: Extensively drug-resistant tuberculosis (XDR TB) is a type of tuberculosis (TB) characterized by resistance to isoniazid and rifampicin, along with resistance to one of the fluoroquinolones and at least one of the second line injectable drugs. Bedaquiline is a diarylq…
Kamolwat P, Nateniyom S, Chaiprasert A, Disratthakit A, Mahasirimongkol S, et al.
Objective To assess the prevalence and risk factors of drug-resistant tuberculosis (TB), the fifth national anti-TB drug resistance survey was conducted in Thailand. Methods A cross-sectional study was conducted by stratified cluster sampling with probability proportional to size…
Lei Wang, Zhidong Teng, Ramziya Rifhat, Kai Wang
Tuberculosis has been prevalent in Xinjiang with severe drug resistance situation. It is unclear that which Mycobacterium tuberculosis (M.tb) infections (drug sensitive or drug resistant) most affected the tuberculosis incidence, how to identify the relative contribution of prima…
Ei PW, Aung WW, Nyunt WW, Swe TL, Htwe MM, et al.
…nmar. Objectives To determine the proportion of extensively drug-resistant TB (XDR-TB) cases among multidrug-resistant TB (MDR-TB) cases and the mutations that cause resistance to second-line drugs in Myanmar. Design This was a cross-sectional, retrospective study. Multidrug-resi…
Sahjid Mukhida, Chanda Vyawahare
…ng are not in common people regarding various categories of drug-resistant TB (DRTB).[2] They don’t have awareness and differentiation about mono-resistant, multidrug-resistant (MDR), poly-drug-resistant (pDR), pre-extensive drug resistance (Pre-XDR), extensive drug resistance (X…