Showing 76–100 of 200 documents
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Gloria Guillermina Guerrero Manríquez
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTb). TB causes mortality of millions of people every year. Mycobacterium bovis Bacillus Calmette Güerin (BCG) is the only officially approved vaccine that protects against miliary TB and children bu…
Nasiri MJ, Lutfy K, Venketaraman V
… immune evasion strategies. Furthermore, the development of vaccines aimed at upregulating glutathione synthesis in macrophages represents a promising strategy to bolster the immune response and improve treatment outcomes. By integrating glutathione and innovative vaccine approac…
Vincent J. C. van Winden, Edith N. G. Houben, Miriam Braunstein
…is and physiology to advance the development of new anti-TB vaccines and antibiotics.
Aymar Akilimali, Hugues Cakwira, Chrispin Biamba, Malik Olatunde Oduoye, Fabrice Kibukila, et al.
The Democratic Republic of Congo (DR Congo), as an African country, has been classified as one of the poorest countries in the world with a weakened and paralyzed healthcare system with various outbreaks of infectious diseases such as tuberculosis (TB) and Corona Virus Disease 20…
Camila Agostinis Silva, Gabriella Montandon Lassi Nunes, Erica Prevital Nery, Maria Gabriela Franco Pereira, Hannah De Araújo Costa Dias, et al.
…ionally, the development of innovative technologies such as vaccines to prevent TB reinfection and immunotherapies to strengthen the immune response against latent tuberculosis is in focus, aiming to shorten the duration of the disease and prevent bacterial resistance.Final Consi…
В. Н. Даниленко
…rains of TB and HIV; (3) develop new genetically engineered vaccines; and, (4) develop new vaccine adjuvants based on probiotic Lactobacillus and Bifidobacterium stains, with selective immunomodulatory activity.
Ravikoti S, Bhatia V, Mohanasundari SK
…ent advancements in TB treatment regimens, diagnostics, and vaccines, emphasizing the importance of these innovations in addressing drug-resistant TB and improving global TB control efforts.
Roland Maes
The WHO was created in 1950 with the prime assignment to fight tuberculosis. To this end, it was granted immunity against any prosecution. The French state immediately exploited this advantage to impose the BCG vaccine developed by the Pasteur institute, although this vaccine was…
Shaik Mallika, Sunil Kumar Kadiri, B. Solomon Sunder Raj, K. Vadivel
…cant challenges, progress in diagnostics, therapeutics, and vaccines provides hope for its eradication by 2050. Continued international collaboration and strong policy efforts remain essential to achieving this global health goal.
Mingyu Gan, Dan Wang, Suqing Li, Qinglan Wang, Qingyun Liu
The Proline-Glutamate/Proline-Proline-Glutamate (PE/PPE) gene family comprises approximately 10% of the(Mtb) genome and is characterized by GC-rich, highly repetitive sequences. As a result, these genes are usually excluded from short-read-based whole-genome sequencing analyses, …
Arth Nana, Nitipatana Chierakul
The Thoracic Society of Thailand under Royal Patronage held their annual scientific conference from 17 to 19 February 2022 in the city of Pattaya, Thailand. The theme was ‘The New Horizon in Pulmonary Medicine’. It was a hybrid meeting with over 300 onsite participants and anothe…
Jamil, Emmama, Aziz, Muhammad Majid, Amir, Afreenish, Godman, Brian, Campbell, Stephen M., et al.
Background/Objectives: Community-acquired pneumonia (CAP) imposes a significant health burden among low and middle-income countries (LMICs). The burden is exacerbated by antimicrobial resistance (AMR) often due to antibiotic misuse and gaps in antimicrobial stewardship (AMS) acti…
Kottakkaran Sooppy Nisar, Muhammad Farman, Dumitru Bǎleanu, SABA JAMIL, Changjin Xu, et al.
…l strategy, considering the potential future application of vaccines for infants and adults. Additionally, the model introduces a quarantine class to address the specific challenges of multidrug-resistant tuberculosis (TB). To capture the complex dynamics of the disease, fractal-…
Fihiruddin Mr., Wayan Tunas Artama, Tri Wibawa, Ni Made Mertaniasih
The effective treatment and accurate diagnosis of tuberculosis (TB) are not established yet. The Bacillus Chalmette-Guerin vaccine did not provide significant results in the prevention of TB and had only 0-80% efficacy. The fbpA and fbpB genes of M. tuberculosis are antigenic pro…
Sichen L, Rui W, Yue Y, Xin L, Youbin C, et al.
Objective: The objective of this study is to determine the drug resistance status of pulmonary tuberculosis patients in Jilin Province. Methods: A retrospective survey was conducted on 395 sputum culture TB-positive patients admitted to the tuberculosis hospital in Jilin Province…
Naidu A, Nayak SS, Lulu S S, Sundararajan V
…discovery and in the designing of the next-generation of TB vaccines. At the end, we give an insight on other computational tools and Machine Learning approaches which have successfully been applied in biomedical research and discuss their prospects and applications against TB.
World Health Organization. Regional Office for Europe
This meeting report highlights the pressing health challenges faced by the WHO European Region, including noncommunicable diseases, tobacco use, vaccine-preventable diseases, vector-borne diseases, HIV, multidrug-resistant tuberculosis, antimicrobial resistance and an aging popul…
Chakaya J, Khan M, Ntoumi F, Aklillu E, Fatima R, et al.
…ancial investments have led to the development of effective vaccines against SARS-CoV2 infection. The world now needs to similarly focus on development of new vaccines for TB utilizing new technological methods.
Ferdous Ara Ahmed, Beatrice Onyinyechi Mkpa, Sadia Afroz, M. Naimul Islam Nakib, Md Nabiul Islam
Background: Tuberculosis (TB) remains a critical public health challenge in Dhaka, Bangladesh, characterized by significant prevalence, treatment, and prevention complexities. This study aims to investigate the trends of TB prevalence, treatment efficacy, and prevention efforts i…
Esteve-Sole A, Sánchez-Dávila SP, Deyà-Martínez A, Freeman AF, Zelazny AM, et al.
Purpose Mendelian suceptibility to mycobacterial disease (MSMD) is a rare primary immunodeficiency predisposing to severe disease caused by mycobacteria and other intracellular pathogens. Delay in diagnosis can have an impact on the patient's prognosis. Methods We evaluated the I…
Dmytro Butov, MD
…e significant efforts are directed at finding new drugs and vaccines against TB. Immune-based interventions are actively sought as an adjunct therapy to conventional ATT. In earlier study the investigators have accidentally observed that when patients with chronic hepatitis C and…
Snow KJ, Cruz AT, Seddon JA, Ferrand RA, Chiang SS, et al.
Adolescence is characterised by a substantial increase in the incidence of tuberculosis, a known fact since the early 20th century. Most of the world's adolescents live in low-income and middle-income countries where tuberculosis remains common, and where they comprise a quarter …
Hadizadeh Tasbiti A, Yari S, Siadat SD, Tabarsi P, Saeedfar K, et al.
Tuberculosis (TB) is a crucial public health problem with prevalence of multidrug resistant (MDR) rising. An accurate TB biomarker is urgently needed to monitor the response to treatment in patients with MDR tuberculosis. To analyze interaction between selected MDR-TB purified pr…
Ashenafi Kelemu Mengistu, Peter J. Witbooi
Despite the recent progress of global control efforts, tuberculosis (TB) remains a significant public health threat worldwide, especially in developing countries, including Ethiopia. Furthermore, the emergence of multidrug-resistant tuberculosis (MDR-TB) has further complicated t…
Mareike Rabe, Jennifer A Hughes
Tuberculosis (TB), particularly drug-resistant TB (DR-TB), remains a major public health concern in South Africa (SA), with children, adolescents, and pregnant and postpartum women (CAPPW) facing heightened risks because of biological and social vulnerabilities. This article high…