TB Research

From Eradication to Reality: Innovative Approaches to TuberculosisTreatment and Control

Shaik Mallika, Sunil Kumar Kadiri, B. Solomon Sunder Raj, K. Vadivel

Anti-Infective Agents · 2026-04

Abstract

Introduction: Tuberculosis (TB) remains a critical global health issue, affecting millions annually. This article examines its worldwide implications, focusing on epidemiology, economic consequences, treatment challenges, antibiotic resistance, and mitigation strategies. Methods: A comprehensive scientific analysis was conducted by reviewing current literature and statistical data on the TB burden, economic impact, and emerging treatment solutions. Results: TB disproportionately affects low- and middle-income nations, particularly India, and leads to long-term financial repercussions. The rise of multidrug-resistant and rifampicinresistant TB (MDR/RR-TB) has further complicated treatment protocols, increasing costs and reducing therapeutic efficacy. However, advancements in diagnostic tools and vaccine development offer promising solutions. Discussion: Policy interventions are crucial to reducing treatment costs and preventing financial hardship caused by high out-of-pocket expenses. Strengthening healthcare infrastructure and improving access to affordable medications are necessary steps. Innovative technologies and new treatment strategies could further enhance global TB management. Conclusion: Although TB presents significant challenges, progress in diagnostics, therapeutics, and vaccines provides hope for its eradication by 2050. Continued international collaboration and strong policy efforts remain essential to achieving this global health goal.

MeSH terms

  • Medicine
  • Tuberculosis
  • Global health
  • Psychological intervention
  • Risk analysis (engineering)
  • Control (management)
  • Intensive care medicine
  • Healthcare system
  • Health care
  • Business
  • Economic growth