Showing 76–100 of 119 documents
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Emmanuel Ifeanyi Obeagu, Bessie Nonyelum Esimai, Getrude Uzoma Obeagu, O. M. T. B. Ochiabuto, Ejike Felix Chukwurah, et al.
…igeria. This study was carried out at the directly observed treatment-short course Tuberculosis (TB DOTS) centre of Federal Medical Centre, Umuahia, located in South-Eastern Nigeria. Therefore, sample size of 240 was used to give room for attrition. A total of two hundred and for…
Carroll A, Vincenti-Delmas M, Maung BM, Htun WPP, Nosten F, et al.
…B programme. METHODS: Routinely collected data on TB cases, treatment outcomes and causes of death were analysed for adult TB cases diagnosed between January 2013 and April 2017. Mortality in the 6 months post-diagnosis was calculated and risk factors were identified using multiv…
Declan I Emegano, Basil B Duwa, A G Usman, Hijaz Ahmad, Dilber Uzun Ozsahin, et al.
…eases the risk of active TB recurrence and prolongs medical treatment for tuberculosis (TB). The study focuses on using advanced machine learning (ML) techniques to predict TB incidence and HIV-TB co-infection using data from the 2023 World Health Organization (WHO) Global TB bur…
Stoica Călăraşu C, Popa Miulescu AM, Turcu AA, Nitu FM
…s (HIV) / tuberculosis (TB) raises important diagnostic and treatment problems as the lung is one of the target organs for HIV. Studies have shown that an HIV patient is 5-15 times more likely to switch from Koch's bacillus-infected status to active tuberculosis. Material and met…
Wondmagegn T, Damtie D, Genetu M, Biadgo B, Lemma M, et al.
… lymphocyte subpopulations before and after anti-tubercular treatment and the effect of intestinal parasites on the cell populations of tuberculosis patients before the initiation of anti TB treatment. Method A prospective cohort study was conducted in the outpatient TB Clinic, U…
Birhanu MY, Bekele GM, Jemberie SS
…both developing and developed countries has made diagnosis, treatment, and control of tuberculosis more difficult. The PCR assay, which is a fast and sensitive technique and an alternative method for detecting multidrug-resistant tuberculosis, is used to determine rifampicin (RIF…
Berra TZ, Gomes D, Ramos ACV, Alves YM, Bruce ATI, et al.
… of 0.69% per month in TB and human immunodeficiency virus (TB-HIV) co-infection, a fall of 0.01% per month in general and lung TB and a fall of 0.33% per month in extrapulmonary TB. With the breakpoint technique, general and pulmonary TB changed in structure in late 2007, and ex…
Tanmaya Talukdar, Shweta Sharma, Vikas Kumar, Kanishk Sinha, Anjali Soin, et al.
TB-HIV coinfection imposes a double-edged sword effect on the patient’s health. Awareness about HIV among the TB patients is very essential for prevention, early detection and appropriate therapy. We aimed to evaluate the knowledge about HIV prevention and transmission among TB p…
Marian Loveday, Jennifer Hughes, Nobuhle Mchunu, Nonhlanhla Yende-Zuma, Kerry Holloway, et al.
… in pregnant women. **METHODS:** Pregnant women initiating treatment for multidrug-resistant/rifampicin-resistant (MDR/RR) TB from 1 January 2018 to 31 March 2024 were included in this prospective, observational study. Maternal TB treatment and pregnancy outcomes were documented…
Gerades Dely Djoufack, Lem Edith Abongwa, Allan Olayemi Campbell, Julian Sydney Olufemi Campbell, Kabir Gorden, et al.
… higher risk of Mycobacterium tuberculosis (MTB) infection. TB-HIV coinfection complicates disease management due to drug interactions, overlapping toxicities, immune reconstitution inflammatory syndrome, and high treatment burdens, potentially driving drug resistance. The emerge…
Ohene SA, Fordah S, Dela Boni P
…. The study objective was to assess the characteristics and treatment outcomes of children with TB from multiple health facilities in Accra, Ghana. Methods A retrospective analyses was conducted using secondary data on children less than 15 years collected from 11 facilities duri…
Roen AO, Podlekareva D, Miller RF, Mocroft A, Panteleev A, et al.
…in 12 months. Use of rifamycin/isoniazid/pyrazinamide-based treatment (HR 0.67, 95% CI 0.50-0.89), TB drug susceptibility testing (DST) and number of active TB drugs (DST + . Lower HCI was associated with an increased probability of death; 30% (95% CI 26-35) vs. 9% (95% CI 6-13) …
Shireen Ashkar
…iting the enzyme. Rifampin is the cornerstone of current TB treatment. It is highly potent against MTB RNAP and MTB with the capability of permeating its thick cell envelope. It has also displayed sterilizing effects against low-metabolizing and slow-replicating MTB in vitro whic…
Atwine D, Bonnet M, Taburet AM
…ugs in human immunodeficiency virus (HIV)-tuberculosis (TB) coinfection treatment but with complex drug interactions, efficacy and safety challenges. We reviewed recent data on EFV and RH interaction in TB/HIV high-burden countries. Methods We conducted a systematic review of stu…
Nilaramba Adhikari, Ratna Bhattarai, Rajendra Basnet, Bhim Singh Tinkari, Badri Nath Gyawali, et al.
…mong 1664 tuberculosis patients registered for tuberculosis treatment during the study period. More than two thirds of tuberculosis patients (67%) were male. The median age of tuberculosis patients was found 32 years. During human immunodeficiency virus testing, 41 out of 1664 tu…
Gebremicael G, Gebreegziabxier A, Kassa D
…enes in the survived control was increased at the end of TB treatment from that at baseline, while decreased in the deceased group. The expression of PTPRCv1, CD3E, CCL5, and IL7R host genes in peripheral blood of patients with TB-HIV coinfected can potentially be used as a predi…
Ogbudebe CL, Adepoju V, Ekerete-Udofia C, Abu E, Egesemba G, et al.
… Understanding the factors that influence tuberculosis (TB) treatment outcomes in children is key to designing interventions to address them. This study aimed to determine the case category distribution of childhood TB in Nigeria and assess which clinical and demographic factors …
Rupani MP, Vyas S
…d a descriptive cross-sectional study among 234 co-infected TB-HIV patients notified in the Bhavnagar region of western India from 2017 to 2020 to estimate the costs incurred, followed by in-depth interviews among program functionaries and patients to explore the solutions for re…
Ayele TK, Doungmo Goufo EF, Mugisha S
… both HIV and TB diseases, case finding for TB and HIV/AIDS treatment. This study aimed to develop optimal HIV/AIDS-TB co-infection mathematical model to explore the best cost-effective measure to mitigate the disease burden. The model is analysed analytically by firstly segregat…
Weldegebreal F, Mitiku H, Teklemariam Z
…ctions are endemic. The aim of this study was to assess the treatment outcome of tuberculosis among Human Immunodeficiency Virus positive patients attending in three hospitals of Eastern Ethiopia. Methods A retrospective clinical record review was conducted for 627 Tuberculosis a…
Ngouanom Kuate MP, Bongomin F, Ndip RN
…cribe the first case of a patient surviving from SARS-CoV-2-TB-HIV triple co-infection in Cameroon. A 36-year-old Cameroonian woman presented at the emergency unit of the Jamot Hospital, Yaoundé with symptoms of anorexia, productive cough, weight loss, and fever. The SARS-CoV-2 r…
Sameer Thakur, Gokul Mishra, Suman Supratik, Sulav Supratik
…tcomes. Understanding the global epidemiology of TB and HIV coinfection is crucial for effective prevention, diagnosis, and management. This intricate interplay between the two diseases significantly impacts diagnosis, treatment, and overall health outcomes. This overview delves …
Olha Konstantynovska, Petro Poteiko, T Synenko, Oleg Stepanov, O Zinenko, et al.
…oportion of patients who died after at least 30 days of the treatment (17 % in 2019 versus 25 % in 2021). Thus, increasing lethality and proportion of TB-HIV coinfection together with the decrease in the number of treated patients may indicate on hidden process of TB in…
Valeria C Rolla, PhD, Valeria C Rolla, PhD
…ients, to be laboratory and clinically monitored during the treatment with lopinavir-ritonavir and rifampin medications. Study population: Thirty patients older than 18 years, both male and female, which present active tuberculosis and failure or contraindication for any motive …
Hosseinian K, Gerami A, Bral M, Venketaraman V
…he emphasis is on the changes that occur as a result of HIV coinfection. With the progression of HIV infection, the primary source of IFN-γ changes from CD4+ to CD8+ T cells, especially when latent TB advances to an active state. This study sheds light on the necessity of develop…