Showing 76–93 of 93 documents
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Elisa Tagliani, Emanuele Borroni, Daniela María Cirillo
…an, Italy. A subgroup of the MDR-TB cases showed additional resistance to 2 nd line anti TB drugs as well as resistance to bedaquiline (linked to a large deletion in the rv0678 gene). One clustered case showed also a minimum inhibitory concentration for delamanid close to the dru…
Alexandra Isakova, Yu. D. Mikhailova, M. A. Sviridenko, Anastasia Khakhalina, Ksenia Galkina, et al.
The paper presents data on testing the drug susceptibility of clinical isolates of M. tuberculosis (MTB) to fluoroquinolones and injectable drugs using molecular genetic tests and phenotypic methods. We demonstrated the diagnostic capabilities of the hybridization technologies «T…
Igor Mokrousov, V. V. Sinkov, П. А. Хромова, Alena Gerasimova, Ekaterina Chernyaeva, et al.
…of this resistant cluster. To conclude, the emerging highly drug-resistant Russian cluster of the <i>M. tuberculosis</i> Beijing genotype is characterized by a combination of potentially significant SNPs in the genes coding for intermediate metabolism and respiration and cell and…
Vyazovaya A, Levina K, Zhuravlev V, Viiklepp P, Kütt M, et al.
…a with a special focus on major epidemic/endemic clones and drug resistance determinants. We investigated the hypothesis of the decisive impact of massive human influx on the locally circulating genotypes. Estonia received a mass immigration from Russia during 1945-90 followed by…
Rupasinghe P, Vereecken J, Graulus P, Decroo T, Ardizzoni E, et al.
Background Phenotypic drug-susceptibility testing (pDST), which relies on growth inhibition in the drug-containing media, remains a challenge for fastidious Mycobacterium tuberculosis complex (MTBc) isolates due to insufficient growth on the growth controls (GC). Middlebrook 7H11…
Jun Ma, Lin Fan, Hongcheng Liu, Wenting Li, Wenwen Sun
…: China is a region with a high global burden of Rifampicin Resistance ／Multidrug-Resistant tuberculosis (RR/MDR-TB) and low HIV incidence. Our aim was to assess the epidemiological and clinical characteristics of RR/MDR-extrapulmonary tuberculosis (EPTB) over the past five years…
Ushtanit A, Kulagina E, Mikhailova Y, Makarova M, Safonova S, et al.
…ionamide are now included in group C of the WHO recommended drugs for the treatment of tuberculosis resistant to rifampicin and multidrug-resistant tuberculosis. The clinical relevance of ethionamide and prothionamide has increased with the wide spread of resistant tuberculosis. …
Rens C, Ceyssens PJ, Laval F, Lefèvre P, Mathys V, et al.
…public health issue. The emergence of multi-and extensively-drug resistant (MDR and XDR) Mycobacterium tuberculosis clinical strains further pinpoint the urgent need for new anti-tuberculous drugs. We previously showed that vancomycin can target mycobacteria lacking cell wall int…
Julia Bespyatykh
…he GyrA (D94A) and inhA promoter (t-8c) associated with the drug resistance. The effects of inhA t-8a mutation was observed on the proteomic and transcriptomic levels. Comparative quantitative proteome analysis revealed an increased representation of proteins coded by the mce1 ge…
Conceição EC, Loubser J, Guimarães AEDS, Sharma A, Rutaihwa LK, et al.
…is with a unique genotype (SIT2517/T1) associated with multidrug-resistant tuberculosis (MDR-TB). To improve our understanding of MDR-TB transmission dynamics of these strains within this region, we performed phenotypic and genotypic drug susceptibility testing (pDST/gDST), 24-lo…
С. Н. Жданова, Anna Vyazovaya, I. B. Lebedeva, V. V. Sinkov, И. Г. Кондратов, et al.
…ion — Kuzbass is characterized by a high prevalence of multidrug-resistant (MDR) tuberculosis (TB), including coinfection with HIV (HIV/TB). A previously unknown in Russia relationship between MDR and the Beijing Central Asian Outbreak (CAO) subtype has been discovered, which upd…
С. Н. Жданова, И. Г. Кондратов, О. Б. Огарков
…und. Irkutsk region maintains a high incidence rate of multidrug-resistant (MDR) tuberculosis (TB). Detection of MDR-associated Mycobacterium tuberculosis strains in Irkutsk region requires dynamic assessment of the TB pathogen population, taking into account the emergence of a n…
О. А. Пасечник, Anna Vyazovaya, A. I. Bloch, Irina Yarusova, M. P. Tatarintseva, et al.
…Omsk region was studied (n = 483). M. tuberculosis culture, drug susceptibility testing, DNA extraction were carried out by standard methods. The M. tuberculosis Beijing genotype and its sublineages and clusters B0/W148 and 94-32 were detected based on the PCR analysis of specifi…
Bouziane F, Allem R, Sebaihia M, Kumanski S, Mougari F, et al.
Objectives To characterise the genotypes of multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) isolated in Algeria, where there is a low MDR-MTB incidence rate. Methods Ten MDR isolates and one resistant to isoniazid were investigated by PCR-Sanger sequencing for 10 loci …
Dana Auganova, Sabina Atavliyeva, Nour Gharbi, Elena Zholdybayeva, Yuri Skiba, et al.
…berculosis in Kazakhstan over the last 50 years. Phenotypic drug susceptibility testing revealed a significant proportion of MDR (46.9%) and pre-XDR (14.7%) isolates. Phylogenetic analysis showed that 67.2% of M. tuberculosis L2/Beijing isolates belonged to the Central Asian outb…
Piamlarp Sangsayunh, Thanyanuch Sanchat, Charoen Chuchottaworn, Krisana Cheewakul, Sirijit Rattanawai
…s conducted. The 8 Pre-XDR patients who exhibited quinolone resistance and the 2 MDR-TB patients who encountered side effected from quinolone drugs were treated with BPaL regimen, while the remainder received BPaLM regimens. RESULTS: Among the 28 patients, 23 (82.1 %) successfull…
Campos DL, Canales CSC, Demarqui FM, Fernandes GFS, Dos Santos CG, et al.
…MDR and pre-XDR strains was superior compared to commercial drugs. These Bfx compounds have a narrow spectrum for mycobacteria, which helps avoid dysbiosis of the gut microbiota, and they also exhibit high selectivity and low toxicity. Synergism studies indicate that Bfx derivati…
João Paulo de Lucena Laet, Lílian Maria Lapa Montenegro, Ana Lúcia Figueiredo Porto, Fábio Rocha Formiga, Ronaldo Nascimento de Oliveira, et al.
… significant activity (MIC >128 µg/mL), indicating possible drug release limitation. Regarding cytotoxicity, the nanoformulation was less cytotoxic, with cell viability ranging from 45% to 99.99%, depending on concentration, compared to the free compound (11% to 95%). Nanoencapsu…