Molecular tests for hybridization analysis in the diagnosis of drug susceptibility of <i>M. Tuberculosis</i> to fluoroquinolones and injectable drugs
Alexandra Isakova, Yu. D. Mikhailova, M. A. Sviridenko, Anastasia Khakhalina, Ksenia Galkina, E. Yu. Nosova, S. G. Safonova
Tuberkulez i socialʹno značimye zabolevaniâ · 2023-12
Abstract
The paper presents data on testing the drug susceptibility of clinical isolates of M. tuberculosis (MTB) to fluoroquinolones and injectable drugs using molecular genetic tests and phenotypic methods. We demonstrated the diagnostic capabilities of the hybridization technologies «TB-TEST and GenoType MTBDRsl v.2 to detect the genetic determinants of resistance in MTB isolates with multidrug and extensively drug resistance (MDR, XDR), as well as in MBT with pre-XDR.
MeSH terms
- Drug
- Tuberculosis
- Medicine
- Pharmacology
- Virology