Showing 76–100 of 200 documents
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Monde N, Munyeme M, Chongwe G, Wensman JJ, Zulu M, et al.
Background Drug-resistant tuberculosis has continued to be a serious global health threat defined by complexity as well as higher morbidity and mortality wherever it occurs, Zambia included. However, the paucity of information on drug-susceptibility patterns of both first-line an…
David Kajoba Mumena, Geoffrey Kwenda, Caroline Ngugi, Andrew Nyerere
Drug-Resistant Tuberculosis (DR-TB) causes high mortality and morbidity rates globally. DR-TB and COVID-19 pandemic are posing a major risk to global public health and economic security, and are jeopardizing efforts in the control, prevention and elimination of TB globally. Mycob…
Medina
With 5,000 new active cases each year, tuberculosis in Chile remains as the most important communicable disease in the country. Since the type of control programs are linked to the epidemiologic situation as far as infection, morbidity and mortality are concerned, an effective su…
Abdelgawad, Noha
Tuberculosis (TB) is the primary cause of death from a single infectious agent worldwide. During the coronavirus disease (COVID-19) pandemic, TB briefly fell to second place, but it has now regained its position as the top infectious killer. It is caused by Mycobacterium tubercul…
Gaurav Sharma, Bharti Malhotra, P. J. John, Shipra Bhargava
…ain purpose of this study is the detection of Mycobacterium tuberculosis (MTB) and its drug resistance profile by molecular methods in pediatric patients suspected of pleural tuberculosis. Children ≤ 15 years of age suspected of pleuritis were enrolled in this study. Total 176 pl…
Merker M, Rasigade JP, Barbier M, Cox H, Feuerriegel S, et al.
…ansmission-driven multi-/extensively drug resistant (M/XDR) tuberculosis (TB) is the largest single contributor to human mortality due to antimicrobial resistance. A few major clades of the Mycobacterium tuberculosis complex belonging to lineage 2, responsible for high prevalence…
Diana Vakhrusheva, Kseniya Belousova, Tatyana Umpeleva, Natalya Eremeeva
…sults of drug susceptibility testing (DST) of Mycobacterium tuberculosis (Mtb) isolated from the sputum of the patient at the preoperative stage of treatment and from its surgical material. <b>Aim:</b> Analysis of the results of DST of Mtb isolated from surgical and respiratory m…
Dreyer V, Mandal A, Dev P, Merker M, Barilar I, et al.
Background Multidrug-resistant (MDR) Mycobacterium tuberculosis complex (MTBC) strains are a serious health problem in India, also contributing to one-fourth of the global MDR tuberculosis (TB) burden. About 36% of the MDR MTBC strains are reported fluoroquinolone (FQ) resistant …
Younghun Kim, Da-Gyum Lee, Jinyoung Bae, Jihee Jung, Hyeongrin Jeon, et al.
…tidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB); however, mutations related to LZD resistance still need to be characterised. This study investigated resistance-related mutations on a whole-genome scale in clinical isolates from patients with MDR/XDR…
Trisakul K, Nonghanphithak D, Chaiyachat P, Kaewprasert O, Sakmongkoljit K, et al.
Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) make TB difficult to control. Global susceptibility data for six newly recommended anti-TB drugs against M/XDR-TB are still limited. Using publicly available whole-genome sequences, we …
Sonnenkalb L, Strohe G, Dreyer V, Andres S, Hillemann D, et al.
…tment failure of multi/extensively drug resistant (MDR/XDR) tuberculosis (TB). Intrapatient evolutionary dynamics of Mycobacterium tuberculosis complex (Mtbc) strains and their implications on treatment outcomes are still not completely understood. To elucidate how Mtbc strains e…
Assefa Hamato Kebede, Hassen Mamo Idris
Abstract Background : Tuberculosis (TB) is one of the oldest diseases known and the spread of drug-resistant TB poses significant challenges in TB control and eradication program globally, and also the distribution varies geographically worldwide and within the countries. Lack of…
Preeti Sharma, Jinendra Singh Chauhan, Birjesh Singh
…dosing, incomplete treatment course, and the ability of the tuberculosis bacilli to tolerate and survive current first-line and second-line anti-TB drugs, in either their latent state or active state, has resulted in an increased prevalence of multidrug-resistant (MDR), extensive…
Diriba G, Alemu A, Yenew B, Tola HH, Gamtesa DF, et al.
…stimate the pooled proportion of extensively drug-resistant tuberculosis (XDR-TB) and pre-extensively drug-resistant tuberculosis (pre-XDR-TB) in patients with multidrug-resistant TB (MDR-TB). Methods We systematically searched articles from electronic databases: MEDLINE (PubMed)…
Chaiyachat P, Kaewseekhao B, Chaiprasert A, Kamolwat P, Nonghanphithak D, et al.
…of pre-extensively (pre-XDR) and extensively drug-resistant tuberculosis (XDR-TB) is challenging. Drug-susceptibility tests for some anti-TB drugs, especially ethambutol (ETH) and ethionamide (ETO), are problematic due to overlapping thresholds to differentiate between susceptibl…
Harun Patel, Iqrar Ahmad, Harsha Jadhav, Rahul Pawara, Anand B. Mundada, et al.
…is the 9th leading cause of death worldwide above HIV/AIDS. Tuberculosis (TB) management remains challenging due to the emergence of drug-resistant tuberculosis such as MDR-TB and XDR-TB. To improvise therapeutic results for MDR/XDR-TB, 89 nations had started utilizing bedaquilin…
Omar SV, Louw G, Ismail F, Liu X, Ngcamu D, et al.
Drug-resistant tuberculosis (TB) poses a significant public health concern in South Africa due to its complexity in diagnosis, treatment, and management. This study assessed the diagnostic performance of the Xpert MTB/XDR test for detecting drug resistance in patients with TB by …
Puspa Acharya, N. K. Bhattarai, Bhuban Raj Kunwar, Khem R. Sharma, Vijay Kumar Khanal, et al.
Abstract Background Drug-resistant tuberculosis poses a significant threat to global TB control efforts, potentially reversing progress made in reducing TB-related morbidity and mortality. This study aims to identify risk factors for multidrug-resistant TB [MDR-TB] in Province 3,…
Lin M, Chen YW, Li YR, Long LJ, Qi LY, et al.
…-based assays used for the rapid diagnosis of Mycobacterium tuberculosis (MTB) and drug-resistant tuberculosis (DR-TB). But studies on its performance are insufficient. Thus, in this study, we conducted a systematic review and meta-analysis to evaluate the effect of LPAs in the d…
David Kajoba Mumena, Geoffrey Kwenda, Caroline Ngugi, Andrew Nyerere
Drug-resistant tuberculosis is a threat to the control of tuberculosis globally, it develops mainly due to mutations in target genes of (MTB). Mutations in the rpoB gene confer resistance to rifampicin (RIF). The most frequent mutations conferring resistance to RIF include; Ser53…
Xu Y, Li Q, Zhu M, Wu X, Wang D, et al.
…idemiological characteristics and profile of drug-resistant tuberculosis (DR-TB) among children with TB in Sichuan province of China.From January 2015 to December 2018, microbiological culture-confirmed child TB cases (aged <15 years old) were enrolled retrospectively. Epidemiolo…
Parissa Farnia, Poopak Farnia, Jalaledin Ghanavi, Saeid Besharati, Ali Akbar Velayati
…model of latency in same clinical isolates of Mycobacterium tuberculosis (MTB). Methods: MTB strains were isolated from clinically and laboratory-confirmed cases of tuberculosis (TB). The TB isolates were subjected to the Xpert MTB/rifampin test and then, further susceptibility t…
Girija Shankar Udgata, Srikanta Dash -
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB), one of the top 10 causes of death worldwide (ranking above HIV/AIDS). About a quarter of the world's population is infected with TB and thus at risk of developing TB disease. The Global TB Repo…
Sharma A, De Rosa M, Singla N, Singh G, Barnwal RP, et al.
Tuberculosis (TB) is a slow growing, potentially debilitating disease that has plagued humanity for centuries and has claimed numerous lives across the globe. Concerted efforts by researchers have culminated in the development of various strategies to combat this malady. This rev…
World Health Organization. Regional Office for Europe
…est proportion of multidrug- and extensively drug-resistant tuberculosis (M/XDR-TB) patients in the world. The Consolidated Action Plan to Prevent and Combat Multidrug- and Extensively Drug-Resistant Tuberculosis in the WHO European Region, 2011–2015 was developed in 2011 and in …