Showing 76–100 of 103 documents
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Rupasinghe P, Vereecken J, Graulus P, Decroo T, Ardizzoni E, et al.
…ing media, remains a challenge for fastidious Mycobacterium tuberculosis complex (MTBc) isolates due to insufficient growth on the growth controls (GC). Middlebrook 7H11 (M7H11) medium contains casein hydrolysate, which may favor the growth of such strains. Method In this study, …
Bouziane F, Allem R, Sebaihia M, Kumanski S, Mougari F, et al.
…se the genotypes of multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) isolated in Algeria, where there is a low MDR-MTB incidence rate. Methods Ten MDR isolates and one resistant to isoniazid were investigated by PCR-Sanger sequencing for 10 loci involved in resistance. …
Suneel Bhooshan, P. K. Khatri
…nd alcohol consumption was associated in 31.2% and 25.8% of tuberculosis cases. In our study mono resistance in isoniazid was 14.20% which was higher than mono rifampicin resistance of 9.20%. Our findings suggest high resistance to isoniazid alone is alarming as these strains may…
Saeed DK, Shakoor S, Razzak SA, Hasan Z, Sabzwari SF, et al.
…tations in the Rv0678, pepQ and atpE genes of Mycobacterium tuberculosis (MTB) have been reported to be associated with reduced antimycobacterial susceptibility to bedaquiline (BDQ). Resistance conferring mutations in treatment naïve MTB strains is likely to have implications for…
…ound of anti-tuberculo-sis chemotherapy, a clinical cure of tuberculosis of the sole lung was achieved with the formation of metatu-berculous fibrotic focal changes without destruction. All patients were persistently abacillated. Conclusion. The proposed multi-stage therapeutic s…
Gupta M, Ish P, Malhotra N
…guidelines on the Programmatic Management of Drug-Resistant Tuberculosis (DR-TB) in India (PMDT) have been released in March 2021 on World TB Day. The new guidelines have considered emerging diagnostic trends including TrueNat, Xpert Mtb/XDR, Next generation sequencing and evalua…
Tatiana Minogina, Leonid Lavrenchuk, Diana Vakhrusheva, Sergey Skornyakov
…l complications and difficulties in detecting Mycobacterium tuberculosis (Mtb) in bone tissue. Molecular diagnostics have improved pathogen detection; however, cases with concomitant HIV andHCV infections remain problematic. These conditions, marked by immunosuppression, systemic…
Akinduti Paul Akinniyi, Ajanaku Christiana Oluwatoyin, Oluwaseun Ejilude, Olumuyiwa Emmanuel Olukayode, Ofem Oluchi Gladys, et al.
… by the clonally diverse multi-drug resistant Mycobacterium tuberculosis complex (MDR-Mtbc) is alarming due to increasing resistance to available antimicrobials which further exacerbates the disease burden. The constituted chemical compounds (chemotypes) in Ocimum sanctum essenti…
Beauty Makamure, Dan Ward, Tsitsi Bandason, Martha Chipinduro, Collins Timire, et al.
Background: Drug-resistant tuberculosis (DR-TB) is a major public health issue in Zimbabwe. Whole-genome-sequencing (WGS) is recommended for studying drug-resistant mutations, lineages, prevalence, and transmission patterns. However, there are limited data on drug-resistant confe…
Pinhata JMW, Brandao AP, Gallo JF, Oliveira RS, Ferrazoli L
… tests 385 phenotypically multidrug-resistant-Mycobacterium tuberculosis isolates from Sao Paulo, Brazil. Discordances were resolved by Sanger sequencing. MTBDRsl correctly detected 99.7% of the multidrug-resistant isolates, 87.8% of the pre-XDR, and 73.9% of the XDR. The assay s…
Lindiwe Modest Faye, Mojisola Clara Hosu, Ntandazo Dlatu, Vatiswa Henge-Daweti, Teke Apalata
…cularly in patients undergoing treatment for drug-resistant tuberculosis (DR-TB). In South Africa, where both TB and HIV are prevalent, the risk of treatment-related auditory damage is especially high. This study aimed to assess the prevalence and predictors of hearing impairment…
Alexandra Isakova, Yu. D. Mikhailova, M. A. Sviridenko, Anastasia Khakhalina, Ksenia Galkina, et al.
… testing the drug susceptibility of clinical isolates of M. tuberculosis (MTB) to fluoroquinolones and injectable drugs using molecular genetic tests and phenotypic methods. We demonstrated the diagnostic capabilities of the hybridization technologies «TB-TEST and GenoType MTBDRs…
Arash Ghodousi, Alamdar Hussain Rizvi, Aiman Baloch, Abdul Ghafoor, Faisal Masood Khanzada, et al.
…s: Seventy three sequential isolates from 31 drug-resistant-tuberculosis patients on bedaquiline-containing regimens were retrospectively tested for bedaquiline resistance by MIC testing in 7H11 medium, and for all isolates showing an increased MIC compared to the baseline isolat…
Olabisi Flora Davies-Bolorunduro, Bharkbhoom Jaemsai, Wuthiwat Ruangchai, Thanakron Noppanamas, Manon Boonbangyang, et al.
There are four major lineages of Mycobacterium tuberculosis (Mtb) whose geographic ranges vary considerably. Mtb lineage 2 (L2) or the East Asia lineage is particularly common in East and Southeast Asia, and also reported worldwide. Most L2 isolates belong to a sublineage L2.2 wh…
MEH Mohamed, MM Mukhtar, ME Hamad, AA Daffalla
… diagnosis, and management outcomes of Multi Drug Resistant-Tuberculosis (MDR-TB) in Sudan.This study aimed to assess MDR-TB diagnosis, management, treatment outcomes and predictors of treatment in Abu-Anga TB Reference Hospital in Sudan between the period 2015 -2021.A retrospect…
Faye LM, Hosu MC, Apalata T
…stigated the characteristics and outcomes of drug-resistant tuberculosis patients in selected rural healthcare facilities in the Eastern Cape, South Africa. A retrospective review of clinical records from 456 patients, covering the period from January 2018 to December 2020, revea…
Wrohan I, Nguyen TA, Nguyen VN, Nguyen BH, Hoang TTT, et al.
…ground Improving treatment outcomes for multidrug-resistant tuberculosis (MDR-TB) is a leading priority for global TB control. This retrospective cohort study evaluated the factors associated with treatment success among patients treated for MDR-TB in two provinces in Vietnam. Me…
Sahjid Mukhida, Chanda Vyawahare
Dear Editor, The global burden of tuberculosis (TB) is not hidden from everyone. Every year, national and international annual reports show the prevalence, disease burden, and mortality of TB nationally and Worldwide.[1] However, there is a lack of adequate knowledge and understa…
Campos DL, Canales CSC, Demarqui FM, Fernandes GFS, Dos Santos CG, et al.
Tuberculosis remains a serious global health threat, exacerbated by the rise of resistant strains. This study investigates the potential of two benzofuroxan ( Bfx ) derivatives, 5n and 5b, as targeted treatments for MDR-TB using in silico , in vitro , and in vivo methodologies. I…
Nurlan Takenov, Alibi Kaziyev, Asfendiyar Mukhamadi, Lyailya Chingissova, Bekzat Toxanbayeva, et al.
Tuberculosis, particularly multidrug-resistant TB (MDR-TB), remains a major public health concern in Kazakhstan, where 26% of new TB cases are MDR, far exceeding the global average. To better understand the genetic diversity, drug resistance, and transmission dynamics ofin Kazakh…
Divya Bhatt, Rashmi Ratnam, Faisal Abbas, Manu Singh, Urmila Singh, et al.
… address such challenges. Robust data analysis of geriatric tuberculosis (TB) is thus essential for preparedness to improve outcomes in this expanding vulnerable population. This study aims to identify the epidemiological, clinical, and comorbidity profiles of TB across various a…
Natalya Eremeeva, Tatyana Umpeleva, Diana Vakhrusheva, Sergey Skornyakov, Leonid Lavrenchuk
The problem of resistance of <i>Mtb</i> to antibiotics is a global threat to humanity. Along with drug resistance, <i>Mtb</i> can also develop resistance to other biocides (e.g. disinfectants), but this phenomenon is currently not well understood and became the goal of this …
Gopalaswamy R, Palani N, Viswanathan D, Preysingh B, Rajendran S, et al.
Background : Patients with first-line drug resistance (DR) to rifampicin (RIF) or isoniazid (INH) as a first-line (FL) line probe assay (LPA) were subjected to genotypic DST using second-line (SL) LPA to identify SL-DR (including pre-XDR) under the National TB Elimination Program…
Elisa Tagliani, Emanuele Borroni, Daniela María Cirillo
Aims and objectives: In the present study, we report on the cross-border clusters involving Italian MDR-TB strains collected in the framework of the ECDC supported EUSeqMyTB project. This pilot study was conducted as retrospective/prospectic WGS-based surveillance project to moni…
Rens C, Ceyssens PJ, Laval F, Lefèvre P, Mathys V, et al.
Treatment of tuberculosis still represent a major public health issue. The emergence of multi-and extensively-drug resistant (MDR and XDR) Mycobacterium tuberculosis clinical strains further pinpoint the urgent need for new anti-tuberculous drugs. We previously showed that vancom…