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Siamisang K, Rankgoane-Pono G, Madisa TM, Mudiayi TK, Tlhakanelo JT, et al.
…male patients. Of the extracted data, 1,366 (22.8%) were of HIV positive patients and 2,966 (49.4%) were of HIV negative patients. The rest of the data were of patients with unknown HIV status. Pulmonary TB accounted for 4,701 (78.3%) of the cases. Overall, 5,591 (93.1%) of the p…
Saadick Mugerwa Ssentongo, Bonniface Oryokot, Ronald Opito, Gerald Ochieng, Peter Sekiranda, et al.
…t completion), which stands at 89.1% for people living with HIV and 91.2% for those without HIV. The Teso region, one of the high TB burden regions in the country, has consistently had a lower treatment success rate (TSR). **OBJECTIVES:** To determine the treatment success and a…
Munanura Turyasiima, Daniel Muliika, Gaston Turinawe, Miriam Acheng, Antony Ikiriza, et al.
…atment completion rate was 82.6% (185/224), with a 30.4% TB-HIV co-infection rate. Significant positive predictors included high TB knowledge (AOR = 14.0; 95% CI: 3.06-24.5), high economic status (AOR = 7.2; 95% CI: 1.63-31.5), belief in treatment effi…
Chihota V, Gombe M, Gupta A, Salazar-Austin N, Ryckman T, et al.
…nate and acquired immunity, many do not. People living with HIV, TB-exposed household contacts, other individuals recently infected, and immunosuppressed individuals are at especially high risk of progressing to TB disease. There have been major advances in recent years to suppor…
Haile H, Tema L, Anjulo A, Temesgen Z, Jerene D
Introduction A large proportion of the global burden of HIV-associated TB occurs in sub-Saharan Africa; including 74% of new cases of TB and 79% of deaths occurs in this area. Spontaneous pneumothorax occurs more frequently in patients with AIDS than the general population with t…
Andrew D. Kerkhoff, Jason Zucker, Diane V. Havlir
…. Clinically focused insights regarding TB, mpox, and other HIV-associated infectious complications that were presented at the 2024 Conference on Retroviruses and Opportunistic Infections (CROI) are summarized in this review.
Kerkhoff AD, Zucker J, Havlir DV
…. Clinically focused insights regarding TB, mpox, and other HIV-associated infectious complications that were presented at the 2024 Conference on Retroviruses and Opportunistic Infections (CROI) are summarized in this review.
Wijk M, Gausi K, Malatesta S, Weber SE, Court R, et al.
… prospectively enrolled participants ≥15 years old, without HIV, and initiating drug-susceptible TB treatment in Worcester, South Africa. Alcohol use was measured via self-report and blood biomarkers. Other illicit substances were captured through a urine drug test. Plasma sample…
Ronald Opito, Keneth Kwenya, Mark Kizito, Susan Alwedo, Baker Bakashaba, et al.
…t 10.4% (n = 129). Older age, undernutrition (Red MUAC) and HIV positive status were significantly associated with lower treatment success: aPR = 0.87(95%CI; 0.80–0.94), aPR = 0.91 (95%CI; 0.85–0.98) and aPR = 0.88 (95%CI; 0.78–0.98); respectively. Patients who were enrolled in 2…
Morounfolu Olugbosi, MD MSc
…atified for co-infection with human immunodeficiency virus (HIV) and cavitation. Participants with Drug Resistant TB (DR-TB): Participants with DR-TB will be assigned to receive BPaMZ daily for 26 weeks (6 months).
Siamisang K, Rankgoane-Pono G, Madisa TM, Mudiayi T, Tlhakanelo JT
…36 years and 41.5% were female. A total of 728 (49.4%) were HIV positive. Pulmonary TB (PTB) accounted for 87.3% of all cases. The overall treatment success rate (TSR) was 81.9% and the mortality rate was 9.4%. Compared to the 16-25 years age group, patients aged more than 65 yea…
Karen D. Serrano, Scott A. Fruhan
… in much of the developing world. Rates of coinfection with HIV are high, and HIV increases the morbidity and mortality associated with TB. This review details the pathophysiology, epidemiology, clinical presentation, and treatment of pulmonary infection, including pneumonia, emp…
Karen D. Serrano, Scott A. Fruhan
… in much of the developing world. Rates of coinfection with HIV are high, and HIV increases the morbidity and mortality associated with TB. This review details the pathophysiology, epidemiology, clinical presentation, and treatment of pulmonary infection, including pneumonia, emp…
Opito R, Kwenya K, Ssentongo SM, Kizito M, Alwedo S, et al.
… 10.4% (n = 129). Older age, undernutrition (Red MUAC), and HIV-positive status were significantly associated with lower treatment success: aPR = 0.87(95%CI; 0.80-0.94), aPR = 0.91 (95%CI; 0.85-0.98) and aPR = 0.88 (95%CI; 0.78-0.98); respectively. Patients who were enrolled in 2…
N Sesay, I F Kamara, A M V Kumar, P Thekkur, A A Alwani, et al.
…comes (7% death, 30% loss to follow-up, 31% not evaluated). HIV co-infection (aRR = 1.2) and HIV-unknown status (aRR = 1.5), residence outside urban areas (aRR = 1.3), and extra-pulmonary TB (aRR = 1.2) were significantly associated with unfavourable outcomes. Children treated in…
Liza Khutsishvili, Carolin Fabian, Kennedy Ngowi, Margaretha Sariko, Krisanta Wilhelm, et al.
…opted to support treatment of human immunodeficiency virus (HIV) in the US was adapted and piloted for HIV/TB care in a distinct urban population, with high usage and improved clinical outcomes. Systematic evaluation of potential contextual influences on mHealth implementation is…
National Institute of Allergy and Infectious Diseases (NIAID)
…participants will include 758 human immunodeficiency virus (HIV)-non-infected individuals, ages 18-60. Participants will be treated with 4 standard drugs called isoniazid, rifampicin, pyrazinamide and ethambutol. All individuals will take TB medicines for at least 4 months. After…
Tijani Sulaimon
… to be alarmingly common, and significantly associated with HIV status, history of previous TB treatment, age, and resistance patterns.Better management of TB, a persistent and complex infectious disease, will require substantial additional research to be conducted in the coming …
Kumari Neha, Jitender K Malik
…ectious diseases that kill people worldwide, second only to HIV, despite advances in detection and treatment. The World Health Organization (WHO) claims that TB is an international pandemic. It is the main cause of death for those with HIV. In India, the fight against TB has larg…
Tyler Scott Johnson, Leah Nanziri, Amanda J Gupta, Joseph M Ggita, Mari Armstrong-Hough, et al.
…** We enrolled 80 participants (28% female; 36% living with HIV). Overall TB knowledge scores increased by 25 points (95% CI 22-28), from 53 to 78, yet only 9% achieved TB literacy (an overall TB knowledge score ≥90) after TB education, peaking at 18% at two weeks, before …
Nurlilah Ab Rahman
…20. Additionally, the increased incidences and spread of TB-HIV dual infections worldwide and the ongoing COVID-19 pandemic have introduced setbacks in the World Health Organization’s plan to diagnose, treat and eradicate TB disease by 2030. Although the introduction of new drugs…
Jennings K, Lembani M, Hesseling AC, Mbula N, Mohr-Holland E, et al.
…ted and compared across cohorts, disaggregated by sex, age, HIV status, TB treatment history and mode of diagnosis. Results There were 27,481 and 19,800 individuals diagnosed with drug-susceptible TB in the pre- and during-COVID-19 cohorts respectively, a relative reduction of 28…
Anil S, Satish Ghatage, Kiran K, Shubha Davalgi, Swathi S Aithal, et al.
…ears, 70.3% were male, 15.3% had a history of TB, 5.5% were HIV reactive, and 20.7% had diabetes. The mean BMI was 18.9 ± 2.8 kg/m². Liquid culture testing found 40 (7.8%; 95% CI: 5.6%-10.5%) patients to be culture positive. Thus, the TB treatment failure rate was 7.8%.…
Ekaterina M. Petrunina, Sergey Skornyakov
…went lung resection in 2024 for localized TB. Patients with HIV or significant comorbidities were excluded. Indications for elective surgery, selection of treatment regimens and evaluation of their effectiveness were conducted in accordance with national Clinical Guidelines. MTB …
Budgell EP, Evans D, Leuner R, Long L, Rosen S
… years (interquartile range 1.0 - 9.5), 44.3% female, 22.7% HIV co-infected, 92.0% pulmonary TB). Treatment success was high (89.8%; 13.6% cured, 76.1% completed treatment), and the mean (standard deviation (SD)) cost per patient with treatment success was ZAR1 820/USD143 (ZAR593…