Showing 51–75 of 200 documents
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Arnold Louie, Michael Neely, Sarah Kim, Charles A Scanga, JoAnne L Flynn, et al.
… There has been little prior effort to identify combination regimens that employ new or repurposed drugs in a rational way. **METHODS AND FINDINGS:** Our group developed a pathway to combine agents to achieve this end. This pathway starts with standard baseline evaluations (e.g.…
Berg A, Clary J, Hanna D, Nuermberger E, Lenaerts A, et al.
…necessitating the development of new and improved treatment regimens. Nonclinical evaluation of candidate drug combinations via the relapsing mouse model (RMM) is an important step in regimen development, through which candidate regimens that provide the greatest decrease in the …
Jindani A, Atwine D, Grint D, Bah B, Adams J, et al.
BACKGROUND: Shorter but effective tuberculosis treatment regimens would be of value to the tuberculosis treatment community. High-dose rifampicin has been associated with more rapid and secure lung sterilization and may enable shorter tuberculosis treatment regimens. METHODS: We …
Soni H, Kumar-M P, Mishra S, Bellam BL, Singh H, et al.
…jective : To compare risk of hepatotoxicity between various regimens for reintroduction of antitubercular therapy (ATT) in patients with previous episode of ATT hepatitis. Methods : We searched various databases (PubMed, Embase, CENTRAL, Scopus, WoS and LILACS) for studies compar…
David Branigan, Claudia M. Denkinger, Jennifer Furin, Petra Heitkamp, Stijn Deborggraeve, et al.
…s to implement the shortest and best available tuberculosis regimens—1 month or once-weekly for tuberculosis prevention, 4 months for drug-sensitive tuberculosis, and 6 months for drug-resistant tuberculosis—by the end of 2024.1McKenna L Frick M Angami K et al.The 1/4/6x24 campai…
Singhal KK, Shinde M
…acceptability of ATT. The available "short-course treatment regimens" are still relatively long, thereby adversely affecting treatment compliance. There is a need for effective, safe, short and intensive regimens for TB which can reduce the treatment cost and adverse effects, the…
Tasneen R, Garcia A, Converse PJ, Zimmerman MD, Dartois V, et al.
…rine models of tuberculosis were used to test whether novel regimens replacing rifapentine and isoniazid with bedaquiline and another drug would maintain or increase the sterilizing activity of the regimen. In BALB/c mice, replacing rifapentine in the PZM backbone with bedaquilin…
Musfardi Rustam, Ratna Djuwita, Sudarto Ronoatmodjo, Erlina Burhan, Evi Martha, et al.
…ster on the 272 th day. The risk of T2DM group with the new regimens in the treatment of DR-TB was 10.66 times (95% CI 3.23-35.12). Whereas, the treatment on NonT2DM group with old regimen with marital status that was controlled showed a significant statistic value with value p&l…
Yohanes Widjaja, Khairuddin Djawad, Saffruddin Amin, Widyawati Djamaluddin, Dirmawati Kadir, et al.
Abstract Introduction . Leprosy is a disease that predominantly affects the skin and peripheral nerves, resulting in neuropathy and associated long-term consequences, including deformities and disabilities. According to the WHO classification, there are two categories of leprosy,…
Jorge Torresi, Ana Angélica Bulcão Portela Lindoso
…lable drugs. The recent implementation of bedaquiline-based regimens represents an advance in combating this condition, although few studies have evaluated the public health impact of their implementation. The present study aimed to evaluate the impacts of implementing oral regim…
Modongo C, Wang Q, Dima M, Matsiri O, Kgwaadira B, et al.
… patients concomitantly receiving rifampicin- and DTG-based regimens under programmatic conditions in Botswana. The outcomes of interest were successful TB treatment and viral load suppression. We used multivariable logistic models to determine predictors for each outcome of inte…
Zhang Y, Zhu H, Fu L, Wang B, Guo S, et al.
…mine in in vitro and animal experiments. To identify potent regimens containing TBI-166 in TB chemotherapy, TBI-166 was assessed for pharmacological interactions in vitro and in vivo with several anti-TB drugs, including isoniazid (INH), rifampin (RFP), bedaquiline (BDQ), pretoma…
Rais M, Abdelaal H, Reese VA, Ferede D, Larsen SE, et al.
…me/boost regimen. More significantly, among all the vaccine regimens tested only repRNA-ID91/ID91+GLA-SE induced IFN-γ and TNF-secreting CD8 + T cells. Furthermore, the repRNA-ID91/ID91+GLA-SE vaccine strategy elicited high systemic proinflammatory cytokine responses and induced …
Gauri Goswami, Pradeep Nirala, Rajeev Tandon, Pulkit Kalra, Mohammed Tariq, et al.
…omorbidities often necessitate alternative non-standardized regimens. Objective The aim of the study was to identify and evaluate the use, rationale, and outcome of non-standardized ATT regimens in patients with drug-sensitive tuberculosis. Method Our prospective observational st…
Yue-E Wu, Jing Cao, Li Wang, Ying-Ji Wei, Hui-Xin Liu, et al.
**BACKGROUND:** Spinal tuberculosis is the most common form of osteoarticular infection, with recommended anti-tuberculosis treatment durations typically being long (9-18 months), even for mild cases, increasing the risks of drug resistance, toxicity, and poor patient adhere…
Kou Y, Wan M, Shi W, Liu J, Zhao Z, et al.
…of the homologous and heterologous prime-boost immunization regimens of these two viral vector-based vaccines remains unclear. In the present study, we constructed recombinant Ad and MVA expressing an Ag85B-TB10.4 fusion protein (AdH4 and MVAH4) and evaluated the impact of their …
Shah R, Khakhkhar T, Modi B
…lysis, we compared the efficacy and safety of different TPT regimens. We searched PubMed, Google Scholar, and medrxiv.org with search terms Tuberculosis Preventive Treatment, TPT, efficacy, safety, and drug regimens for TPT and all RCT, irrespective of age, setting, or co-morbidi…
Tmp Nguyen, T.H.M. Le, C.S.C. Merle, L. Guglielmetti, N.L. Nguyen, et al.
… in the same year. 1 In 2025, the WHO recommended different regimens for RR-TB patients without confirmed fluoroquinolones (FQ) resistance, one of which is a 5-drug 9-month treatment regimen, based on results of the endTB clinical trial.This so called BCLLfxZ regimen includes bed…
Stephen H Gillespie, MB BCh BAO MD DSc, Andrew Nunn, BSc MSc, Sarah K Meredith, MB BS MSc, Timothy D McHugh, BSc PhD CSi, Ali Zumla, BSc MBChB MSc PhD, et al.
…erculosis". REMoxTB aims to find and evaluate new drugs and regimens that shorten the duration of tuberculosis therapy. The purpose of REMoxTB is to evaluate the efficacy, safety and acceptability of two moxifloxacin-containing treatment combinations to determine whether substit…
Edmund Shen, Mikanda Kwabisha Kunda, Stephane Mpinda, Allison LaHood, Letizia Trevisi, et al.
…. Historically, effective therapy was hindered by prolonged regimens and drug toxicity. Recent clinical trials and observational studies demonstrated the potential of shortened all-oral regimens in improving treatment outcomes, leading the WHO to recommend several standardized 6 …
Kendra Brett, Melissa Severn
…r treating active tuberculosis (TB), some 4-month treatment regimens may be as effective and safe as the standard 6-month treatment regimen. However, there are also 4-month treatment regimens that seem to be less effective than the 6-month treatment regimen for treating active TB…
H. Mursaloglu, Can Akın, Cansu Yilmaz, Pınar Ergenekon, Yasemi̇n Gökdemi̇r, et al.
…redictors of treatment failure, the efficacy of eradication regimens and long-term clinical outcome in our CF center. <b>Methods:</b> 309 patients were involved in the study. All sputum cultures collected between 2015-2019 were reviewed. Clinical findings, demographics and eradic…
Natalia Yatskevich, G. L. Gurevich, E. M. Skryagina, Elmira Gurbanova
… to evaluate the effectiveness of 39- and 24-week treatment regimens in patients with multiple drug resistant or rifampicin-resistant tuberculosis (MDR/RR-TB). Subjects and Methods . We evaluated the effectiveness of 39- and 24-week treatment regimens containing bedaquiline, levo…
Mariah Benedict Raj P, Ganta GK, Durai Singh C, Muthusamy R
…. This study aimed to estimate the efficacy of TB treatment regimens and their successful outcomes in a retrospective analysis carried out in a tertiary health care hospital. Materials and methods A retrospective analysis was carried out on the patients diagnosed with TB and trea…
Aruldhas BW, Hoglund RM, Ranjalkar J, Tarning J, Mathew SK, et al.
…drug levels in children with the currently available dosing regimens. This study attempted to investigate the pharmacokinetics of isoniazid and rifampicin, when used in children, and to optimize their dosing regimens. Methods Data were collected from 41 children, aged 2-16 years,…