Showing 51–75 of 200 documents
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Camilo A. Ruiz-Bedoya, Filipa Mota, Elizabeth W. Tucker, Farina J. Mahmud, Maria Reyes‐Mantilla, et al.
Tuberculous meningitis (TB meningitis) is the most severe form of tuberculosis (TB), requiring 12 months of multidrug treatment for cure, and is associated with high morbidity and mortality. High-dose rifampin (35 mg/kg/d) is safe and improves the bactericidal activity of the sta…
Ethel M Weld, MD
…(IRIS). The option of dual therapy for HIV (i.e., complete regimens to treat HIV composed of only 2 drugs) is of increasing interest and can lower costs for patients, payors, and programs while lowering cumulative lifetime exposure to ART (with potential resultant lessened burde…
Juliana F Oliveira, MD, Marcus B. Conde, PhD, Rosana S. Rodrigues, MD, Sara L. Menezes, PhD, Ana L. Boechat, MD, et al.
Tuberculosis (TB) remains as an important public health problem worldwide. Pleural tuberculosis is the most prevalent form of extrapulmonary presentation in immunocompetent patients. The volume of effusion in the pleural space of patients with pleural TB may cause complications …
Dian S, Ganiem AR, Te Brake LH, van Laarhoven A
… tools and ongoing research aimed at improving TB treatment regimens, the mortality rate for neurotuberculosis remains high. While antituberculosis drugs were discovered in the 1940s, TB treatment regimens were designed for and studied in pulmonary TB and remained largely unchang…
Heid-Picard B, Mougari F, Pouvaret A, Lanternier F, Awad Z, et al.
…an pulmonary M. abscessus infections. To evaluate treatment regimens, we retrospectively analyzed consecutive microbiologically confirmed EP-MAB cases diagnosed in France during 2012-2020. We studied 45 patients with EP-MAB, including 14 bone and joint infections, 10 skin and sof…
Ludi Z, Sule AA, Samy RP, Putera I, Schrijver B, et al.
…challenges combined with the lack of standardized treatment regimens this results in uncertain OTB outcomes. The purpose of this study is to summarize existing diagnostic approaches and recently discovered biomarkers that may contribute to establishing OTB diagnosis, choice of an…
Julie Huynh, Chishala Chabala, Suvasini Sharma, Louise Choo, Varinder Singh, et al.
…randomised clinical trial. Trials evaluating ATT shortening regimens using high-dose rifampicin and drugs with better central nervous system penetration alongside adjuvant anti-inflammatory therapy are needed to improve outcomes. **METHODS AND ANALYSIS:** Thehortened Intensive T…
Rafael Laniado-Laborı́n
Although the underlying general principles of management of tuberculosis are the same for all cases, there are certain special situations in which the treatment regimen must be modified. Uremia and post-renal transplant are both risk factors for tuberculosis due to the underlying…
Ding J, Thuy Thuong Thuong N, Pham TV, Heemskerk D, Pouplin T, et al.
The most effective antituberculosis drug treatment regimen for tuberculous meningitis is uncertain. We conducted a randomized controlled trial comparing standard treatment with a regimen intensified by rifampin 15 mg/kg and levofloxacin for the first 60 days. The intensified regi…
Yang H, Liu Q, Wu Y, He K, Zeng Q, et al.
…er time. Importantly, our data suggest that INSTI-based ART regimens do not elevate the risk of TB-IRIS. Thus, paradoxical TB-IRIS should not be considered an impediment to initiating ART in adults with advanced immunodeficiency, except in the case of tuberculous meningitis (TBM)…
Shi C, Yang B, Yang J, Song W, Chen Y, et al.
… duration, type of TB (extrapulmonary) and some therapeutic regimens between ADR group and non-ADR group, respectively. Multivariate logistic regression analysis showed that treatment duration (OR = 1.029, 95%CI[1.018-1.040], P = .000), type of TB (extrapulmonary, OR = 1.487, 95%…
Qian Su, Jie Xiao, Zhou Peng, Liang Zhou, Juan Wang, et al.
**BACKGROUND:** The early clinical diagnosis of tuberculosis (TB) in kidney transplant recipients is difficult, and TB is one of the major infectious disease-related causes of morbidity and death in transplant recipients. This study analyzed the characteristics of patients who de…
Cybele Lara R Abad, Alex Zimmet, Aruna K Subramanian
…ian of 54.5 (range 2-180) days after starting ATT. Many ATT regimens were modified in the post-transplant phase (31/44, 70.4%). Of nine mortalities among LT recipients, only one was directly attributable to TB disease. For both cohort studies on KT candidates, EPTB was the most c…
Karol F Boschung, Patrick H P Wong, Denise Werry, Inna Sekirov, Shannon L Turvey, et al.
…ncidence setting. Both patients were treated with multidrug regimens including bedaquiline, a nitroimidazole, cycloserine, and linezolid. Drug selection was informed by molecular diagnostics, susceptibility testing, and pharmacokinetic and clinical data. Adverse events included s…
Lanni F, Antilus Sainte R, Hansen M Jr, Parigi P, Kaya F, et al.
…M would also be of great value to prioritize promising drug regimens to be tested in clinical trials, given the healthy state of the development pipeline for the first time in decades. Here, we report the optimization of a rabbit model of TBM disease induced via inoculation of My…
Fahmy Mohammed, Diyar Adnan Mohammed, Mir Misbahuddin, Suneel Mohammed, O.S. Mohammad, et al.
Abstract INTRODUCTION: Central nervous system (CNS) tuberculosis represents approximately 10% of extra pulmonary tuberculosis. Tuberculous arachnoiditis is a rare complication of CNS tuberculosis that can result in debilitating peripheral neurological deficits and varying atypica…
Dr Govind K Makharia, MD, DM, DNB
Most of the guidelines on the treatment of tuberculosis suggest that 6 months treatment is sufficient for extrapulmonary tuberculosis except for bone tuberculosis and tubercular meningitis. Despite these recommendations, most physicians treating abdominal tuberculosis use antitub…
Charlie L, Abay SM, Tesfaye A, Mlera RN, Mwango S, et al.
…reatment strategy is based on pulmonary TB (PTB) management regimens which consider rifampicin as the backbone. Optimal treatment regimens for PTB may not be the most effective option for TBM due to difference in TB drug penetration across the blood-cerebrospinal fluid barrier, h…
Mohd Jaish Siddiqui, Yang Liu, Yu Zhu, Qin Guo, Chaomin Wan, et al.
To the Editors: Laryngeal tuberculosis (TB) is a rare manifestation of extrapulmonary TB, at present the incidence rate is 1% of all cases, compared to in the 20th century, the impacted rate was 25%–30% of all TB cases.1 Here, we present a case of laryngeal TB with miliary TB and…
Víctor Asensi, Juan J. Palacios, María Rivas-Carmenado, Tomás Suárez‐Zarracina, Enrique García-Carús, et al.
…(INH) and ethambutol (EMB) are included in all the standard regimens against M.kansasii. We report a case of a healthy 65-year-old male farmer who presented with isolated right supraclavicular lymphadenopathy. The lymph node FNA showed acid-fast-bacilli and granulomatous inflamma…
Chandramouli Bhattacharya, Tanmay Mukherjee, Sayan Das, Prasad Krishnan
Sir, Vertebrae are the commonest site of skeletal tuberculosis[1] and the vast majority of them occur in the thoracic and lumbar spine. Isolated coccygeal tuberculosis is a very rarely reported entity.[1–4] A 73-year-old lady with history of chronic kidney disease on maintenance …
Bella Devaleenal Daniel, Leeberk Raja Inbaraj, D. Tumu
… impacts TB research globally. The need for newer treatment regimens with different doses of the recommended drugs or newer drugs for the management of all forms of TB is being explored globally. This includes adjusting doses of recom- mended drugs, replacing drugs based on pharm…
Misra UK, Kumar M, Kalita J
…ing the inclusion criteria were randomized to four drug ATT regimens (rifampicin, isoniazid, ethambutol and pyrazinamide) administered either simultaneously (standard arm) or one after another (sequential arm) in a 1 : 1 ratio. The primary endpoint was drug-induced hepatitis (DIH…
Shanindra De Alwis, Arjuna Fernando
<h3>Objective:</h3> NA <h3>Background:</h3> Tuberculous Meningitis (TBM) is a challenging entity to diagnose as well as to treat. Most of the treatment principles are based on data from pulmonary Tuberculosis (TB). The Fixed Dose Combination (FDC) formulation is currently recomme…
Gudisa Bereda
Tuberculosis is more sophisticated to diagnose in pregnant women contract the diseases because tuberculosis clinical manifestations suchlike tiredness, difficulty of breathing, sweating, weakness, coughing, and rare body temperature that is higher than normal are identical to the…