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Gu P, Lu P, Ding H, Liu Q, Ding X, et al.
…ound To compare the effectiveness, cost, and safety of four regimens recommended by the World Health Organization (WHO) for rifampicin resistance/multidrug-resistance tuberculosis (RR/MDR-TB) Treatment in Eastern China. Methods We performed a cohort study among patients with RR/M…
Shanghai Pulmonary Hospital, Shanghai, China
…ity (EBA), safety, and tolerability of 4-month short-course regimens containing bedaquiline, moxifloxacin, and pyrazinamide in patients with drug-susceptible tuberculosis. This is a prospective, randomized, controlled, multicenter study planned to enroll 45 rifampicin-susceptible…
Kwonjune J. Seung, Cathy Hewison
…rug-resistant tuberculosis to more effective and safer drug regimens that avoid debilitating side-effects, such as permanent hearing loss.2Farmer PE Better and safer treatment for multidrug-resistant tuberculosis.Lancet. 2018; 392: 798-800Summary Full Text Full Text PDF PubMed Sc…
Danyuchen Sun, Zhili Li, Yingpeng Qiu, Wei Shu, Lijie Zhang, et al.
…valuate the cost-effectiveness of two novel drug containing regimens compared to traditional regimen in Chinese adult population. **METHODS:** We performed a cost-effectiveness analysis from the perspective of the patient. Clinical treatment information and outcomes were retrosp…
Sisay M, Edessa D, Ayele Y, Getachew M
…pattern of and reasons for change of antiretroviral therapy regimens among HIV/AIDS patients at Jugel Hospital, Eastern Ethiopia. Methods A retrospective cross-sectional study was conducted to review medical records of 220 patients who had been on treatment and experienced regime…
Ryckman TS, McQuaid CF, Cohen T, Menzies NA, Kendall EA
…of separate rifampicin-susceptible and rifampicin-resistant regimens. We estimated incremental cures; averted deaths, secondary cases, and costs; and prices below which a pan-tuberculosis regimen would be cost saving. We also assessed scenarios intended to describe which mechanis…
Tari Nur Fauziyantini, Umi Yuniarni, Lanny Mulqie
…since 2023, Indonesia has implemented several TB-RO therapy regimens, namely BPaLM (6 months), BPaL (6 months), 9 month regimen, and long-term regimen (18-24 months). The choice of regimen is based on the patient's condition, treatment history, and level of resistance to certain …
N.А. Lytvynenko, Y. I. Feschenko, Maryna Pogrebna, A.S. Lapheta, L.V. Shcherbakova, et al.
…iveness of various shortened standard or modified treatment regimens for patients with multidrugresistant tuberculosis. Materials and methods. A prospective observational study was carried out to study different shortened AMBT regimens for 346 patients with multidrug-resistant t…
Ding Y, Zhu H, Fu L, Zhang W, Wang B, et al.
…after 8 weeks). In conclusion, oral short-course three-drug regimens, including TBI-166 with high efficacy, were identified. The TBI-166+BDQ+PZA regimen is recommended for further study in a TBI-166 phase IIb clinical trial.
Nsengiyumva NP, Campbell JR, Oxlade O, Vesga JF, Lienhardt C, et al.
…r, and cheaper tuberculosis (TB) preventive treatment (TPT) regimens will enhance uptake and effectiveness. WHO developed target product profiles describing minimum requirements and optimal targets for key attributes of novel TPT regimens. We performed a cost-effectiveness analys…
R. Swapna, Karanth M P Swathi, M. Somashekar, Asit Kumar Chakraborty, J.S. Akshata, et al.
…entional longer regimen. Evaluating the performance of both regimens in a programmatic setting will help in tailoring the treatment regimen of MDR-TB. Objectives: To estimate the duration of sputum smear conversion in the shorter MDR-TB regimen. 2. To compare the treatment outcom…
Malik Zohaib Ali, Taru S. Dutt, Amy L. MacNeill, Amanda Walz, Camron Pearce, et al.
…ltaneously avoiding the L-associated AEs. The BPaL and BPaS regimens were compared in the BALB/c and C3HeB/FeJ murine chronic TB efficacy models. After 4-weeks of treatment, both regimens promoted equivalent bactericidal effect in both TB murine models. However, treatment with BP…
Narendran Gopalan, DNB (Chest), Soumya Swaminathan, MD
…dividuals treated for TB treated with standard intermittent regimens. The study would generate data on the efficacy of daily and thrice weekly regimen of ATT in pulmonary TB patients with HIV in the presence of highly active antiretroviral therapy (HAART). Not many trials have co…
Malik Zohaib Ali, Taru S Dutt, Amy MacNeill, Amanda Walz, Camron Pearce, et al.
…ltaneously avoiding the L-associated AEs. The BPaL and BPaS regimens were compared in the BALB/c and C3HeB/FeJ murine chronic TB efficacy models. After 4-weeks of treatment, both regimens promoted equivalent bactericidal effect in both TB murine models. However, treatment with BP…
Masayuki Ikeda, Hiroki Matsui, Yasuhiro Morimoto, Norihiko Kubota, Tatsuya Nagai, et al.
…%) patients received clarithromycin- and azithromycin-based regimens, respectively. The aORs for initial regimen modification were as follows; age 1.05 (95% CI; 1.01-1.10), women 0.77 (95% CI; 0.34-1.74), body mass index 1.06 (95% CI; 0.96-1.18), smear-positive status 0.85 (95% C…
Malik Zohaib Ali, Taru S Dutt, Amy MacNeill, Amanda Walz, Camron Pearce, et al.
…ltaneously avoiding the L-associated AEs. The BPaL and BPaS regimens were compared in the BALB/c and C3HeB/FeJ murine chronic TB efficacy models. After 4-weeks of treatment, both regimens promoted equivalent bactericidal effect in both TB murine models. However, treatment with BP…
Innocent Murhula Kashongwe, Leopoldine Mbulula, Fina Mawete, Nicole Anshambi, Nadine Maingowa, et al.
…w approach improved favorable outcomes. Both short and long regimens reached a high level of favorable outcome compared to the previous study. The short regimen, well supervised seems to be superior to the long regimen in term of Death rate and loss to follow up (LTFU).
Bavesh D Kana
…ltaneously avoiding the L-associated AEs. The BPaL and BPaS regimens were compared in the BALB/c and C3HeB/FeJ murine chronic TB efficacy models. After 4-weeks of treatment, both regimens promoted equivalent bactericidal effect in both TB murine models. However, treatment with BP…
Malik Zohaib Ali, Taru S Dutt, Amy MacNeill, Amanda Walz, Camron Pearce, et al.
…ltaneously avoiding the L-associated AEs. The BPaL and BPaS regimens were compared in the BALB/c and C3HeB/FeJ murine chronic TB efficacy models. After 4-weeks of treatment, both regimens promoted equivalent bactericidal effect in both TB murine models. However, treatment with BP…
Hisayuki Shuto, Kosaku Komiya, Akihiko Goto, Takamasa Kan, Kokoro Honjo, et al.
…ficacy and safety of fluoroquinolone-containing combination regimens as an alternative remain uncertain. This study aimed to compare the efficacy and safety of fluoroquinolone-containing regimens with those of the standard regimens for treating pulmonary MAC disease. METHODS: We …
Azmeraw M, Workineh Y, Girma F, Kassaw A, Kerebeh G, et al.
…rtant to maintain children's initial antiretroviral therapy regimens. However, the incidence and predictive factors of initial antiretroviral therapy regimen changes in the research context are still unknown in the study setting. So, the study was aimed to assess incidence and pr…
Kohler S, Sitali N, Achar J, Paul N
…hs), 10 shorter (9-12 months), and 8 short (≤6 months) drug regimens for drug-sensitive (DS) and multidrug-resistant (MDR)-TB treatment. Costs per regimen were estimated by multiplying recommended drug amounts with 2021 Global Drug Facility prices and drug import costs of a TB pr…
Nunn AJ, Phillips PPJ, Meredith SK, Chiang CY, Conradie F, et al.
…idrug-resistant tuberculosis who received existing drugs in regimens shorter than that recommended by the World Health Organization (WHO) in 2011. Methods We conducted a phase 3 noninferiority trial in participants with rifampin-resistant tuberculosis that was susceptible to fluo…
Taipei Medical University WanFang Hospital
… (Ri-TB) and TB patients for whom rifamycin-sparing anti-TB regimens are preferred due to drug-drug interaction (Rs-TB). Trial intervention The novel regimen will be given in two phases: 1. An intensive phase consisting of isoniazid, bedaquiline, moxifloxacin and pyrazinamide …
Lyndon P. James, Fayette Klaassen, Sedona Sweeney, Jennifer Furin, Molly F. Franke, et al.
…ging evidence suggests that shortened, simplified treatment regimens for rifampicin-resistant tuberculosis (RR-TB) can achieve comparable end-of-treatment outcomes to longer regimens. We compared a 6-month regimen containing bedaquiline, pretomanid, linezolid, and moxifloxacin (B…