Showing 51–75 of 93 documents
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MEH Mohamed, MM Mukhtar, ME Hamad, AA Daffalla
…ce, prevalence, diagnosis, and management outcomes of Multi Drug Resistant-Tuberculosis (MDR-TB) in Sudan.This study aimed to assess MDR-TB diagnosis, management, treatment outcomes and predictors of treatment in Abu-Anga TB Reference Hospital in Sudan between the period 2015 -20…
Yogesh Yadav, JYOTI CHOUDHARY, MOHAMMED NASIR KHAN
Objective: This study aimed to identify drug-resistant tuberculosis cases and treatment results. Because it is one of the few studies that have looked at the results of TB treatment among children in the nation, this one was noteworthy. Methods: Drug-resistant cases of paediatric…
Saeed DK, Shakoor S, Razzak SA, Hasan Z, Sabzwari SF, et al.
…uced antimycobacterial susceptibility to bedaquiline (BDQ). Resistance conferring mutations in treatment naïve MTB strains is likely to have implications for BDQ based new drug regimen that aim to shorten treatment duration. We therefore investigated the genetic basis of resistan…
Kamal Ahmadi, Nahid Madadi-Goli, M Masoumi, Mahshid Nasehi, Seyed Davar Siadat, et al.
…eases worldwide. Epidemiological studies of M. tuberculosis drug resistance are critical for improving patient treatment approaches and controlling the spread of tuberculosis. The present study aimed to determine antibiotic resistance among M. tuberculosis clinical isolates using…
Mogashoa T, Loubser J, Choga OT, Ngom JT, Choga WT, et al.
Background The emergence of drug-resistant Mycobacterium tuberculosis ( M. tb ) strains remains a threat to tuberculosis (TB) prevention and care. Understanding the drug resistance profiles of circulating strains is crucial for effective TB control. This study aimed to describe t…
Hameed HMA, Tan Y, Islam MM, Guo L, Chhotaray C, et al.
…xifloxacin (MXF) are the cornerstones for treatment of multidrug-resistant tuberculosis (MDR-TB). China is one of the highest MDR- and fluoroquinolones (FQ)-resistant TB burdens countries. DNA gyrase encoded by gyr genes is the main target of FQ in Mycobacterium tuberculosis (MTB…
Divya Bhatt, Rashmi Ratnam, Faisal Abbas, Manu Singh, Urmila Singh, et al.
…dia. Data were analyzed for age, gender, site of infection, drug resistance patterns, and associated comorbidities. Comparative assessments were performed among the geriatric cohort (≥ 60 years; mean age, 67.88 ± 6.63 years), the adult group (19&#…
Suneel Bhooshan, P. K. Khatri
Drug resistance in MTB is alarming because of the limited choice of drugs available for treatment. First line drugs are safe, effective and cheaper than second line drugs. Any resistance in rifampicin or isoniazid will increase the chances of sensitive MTB strain to shift toward …
А. В. Мордык, О. Г. Иванова, S. V. Sitnikova, V. I. Gusina, A. O. Ptukhin
…e continued decline in the number of patients shedding multidrug-resistant mycobacteria (MDR MDR), which has continued since 2018, determines the priority of measures to improve the effectiveness of treatment of newly diagnosed patients, including HIV-associated tuberculosis, wit…
М.В. Ураксина, E. P. Еremenko, Е. А. Бородулина, B. Borodulin
… treatment of tuberculosis (TB) patients is the increase in drug resistance of M.tuberculosis, which is not always detected at the start of chemotherapy, which leads to inadequate and lengthy treatment. Research objective . Analysis of the treatment of newly diagnosed patients ac…
Igor Mokrousov, Anna Vyazovaya, Neliya Vasilieva, Regina Mudarisova, Natalia Solovieva, et al.
…ong-term observation showed an increase in mutations in the drug resistance genes in strains of the Beijing B0/W148 cluster (Russian epidemic strain). The first isolates from 8 patients were MDR, from 5 – pre-XDR. In the follow-up, XDR strains were isolated from three more MDR-TB…
Rosângela Siqueira Oliveira, Angela Pires Brandao, Fabiane Maria de Almeida Ferreira, Sonia Maria da Costa, Vera Lucia Maria Silva, et al.
Drug-resistant tuberculosis (DR-TB) threatens global TB control. We investigated the prevalence and molecular characteristics of second-line drug resistance among rifampicin (RIF)- and/or isoniazid (INH)-resistantcomplex (MTBC) isolates in São Paulo, Brazil, using the MTBDRv…
Soumya Renji, Rekha Solomon, Deepali Wankhade, Soonu Udani, Vrajesh Udani
…g) between January, 2007 and December, 2019 were retrieved. Drug resistance was classified as per World Health Organization definitions. RESULTS: 59 children (28 boys) met the inclusion criteria (median (IQR) age 8 (4,13) years). About a third (22/59) had past history of treatmen…
Fábio Rocha Formiga, Giovanna Gabriela Pedroza Rodrigues, Luanna de Ângelis Correia de Sousa, Douglas Dourado Oliveira, Ronaldo Nascimento de Oliveira, et al.
…s approach becomes even more relevant given the increase in resistance to traditional drugs. Triazole derivatives emerge as relevant candidates due to their antimycobacterial potential. However, they face issues related to stability, bioavailability, and toxicity. Therefore, nano…
Renji S, Solomon R, Wankhade D, Udani S, Udani V
…g) between January, 2007 and December, 2019 were retrieved. Drug resistance was classified as per World Health Organization definitions. Results 59 children (28 boys) met the inclusion criteria (median (IQR) age 8 (4,13) years). About a third (22/59) had past history of treatment…
Marie José Bajani Kabedi, Steve Ahuka, Octavie Metila Lunguya, Jean Marie Kayembe, Hippolyte Nani Tuma Situakibanza, et al.
… study was to determine the frequency of TB and the primary resistance of Mycobacterium tuberculosis strains to antituberculosis drugs as well as genetic variants. Methods. The study is cross-sectional and descriptive carried out between June 2011 and December 2017 in Kinshasa am…
Anusmriti Pal, Tanka Acharya, Kamal Hamal, Nanda Acharya, Khadga Bikram Shah
…d) 16.7%, Extra-pulmonary 28.6% with one case of each multi-drug resistant tuberculosis (MDR-TB), and Pre-XDR (Extensive drug resistant) TB. Among them, 12% of people had a history of TB undergone ATT (anti-tuberculosis drugs) in the past with 6% having a close contact history. &…
Naima Nur, Azaz Bin Sharif, Anish Khan, Md Rashedul Islam, Hafid Soualhine, et al.
…ntial to address the high incidence of the disease, as multidrug-resistant pulmonary TB (MDR-PTB) remains a significant concern to halt pre-extensive drug-resistant (pre-XDR) recrudescence. The objective of the current study was to examine and compare MDR-PTB patterns among adult…
Ghosh A, Biswas VK, Bal HB, Das D, Pati S, et al.
… strategy, this study seeks to comprehend the diversity and drug resistance pattern in the eastern region. A total of 102 M. tuberculosis isolates from North East (n = 54), and Odisha (n = 48) were sequenced along with 7 follow up isolates from Sikkim. The pre-XDR and XDR isolate…
Che Y, Bo D, Lin X, Chen T, He T, et al.
Background Detection of pyrazinamide (PZA) resistance in Mycobacterium tuberculosis (TB) patients is critical, especially in dealing with multidrug-resistant Mycobacterium tuberculosis (MDR-TB) case. Up to date, PZA drug susceptibility testing (DST) has not been regularly perform…
Fernandez Do Porto DA, Monteserin J, Campos J, Sosa EJ, Matteo M, et al.
…m, 10 fixed variants) emerged, most of them associated with drug resistance. The first isolate was already resistant to isoniazid, rifampicin, and streptomycin, thereafter the strain developed resistance to fluoroquinolones and pyrazinamide. Surprisingly, isolates remained suscep…
Gopalaswamy R, Palani N, Viswanathan D, Preysingh B, Rajendran S, et al.
Background : Patients with first-line drug resistance (DR) to rifampicin (RIF) or isoniazid (INH) as a first-line (FL) line probe assay (LPA) were subjected to genotypic DST using second-line (SL) LPA to identify SL-DR (including pre-XDR) under the National TB Elimination Program…
Ushtanit A, Mikhailova Y, Krylova L, Grigorash D, Makarova M, et al.
The emergence of drug-resistant tuberculosis forced the development of new drugs and the screening of more effective or less toxic analogues. Mycolic acid biosynthesis is targeted by several antituberculosis drugs, isoniazid being one of the most important in tuberculosis therapy…
San LL, Aye KS, Oo NAT, Shwe MM, Fukushima Y, et al.
…tion high tuberculosis (TB) burden country with a high multidrug-resistant (MDR)-TB burden. Of significance, a high prevalence of the Beijing genotype of Mycobacterium tuberculosis (MTB) among MDR-MTB has been reported previously. A detailed genetic characterization of TB clinica…
Arash Ghodousi, Alamdar Hussain Rizvi, Aiman Baloch, Abdul Ghafoor, Faisal Masood Khanzada, et al.
…e first seven cases of acquired bedaquiline and clofazimine resistance identified in Pakistan. The study was conducted within the framework of a retrospective surveillance project to monitor the acquisition of resistance to bedaquiline implemented by the National TB Reference Lab…