Showing 51–75 of 200 documents
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Li Q, Zhao G, Wu L, Lu M, Liu W, et al.
Background To evaluate prevalence and patterns of drug resistance among pulmonary tuberculosis (TB) patients in Hangzhou City, China. Methods Sputum samples of smear positive TB patients enrolled in 2011 and 2015 were collected and tested for drug susceptibility, and demographic …
Pan Y, Yu Y, Lu J, Yi Y, Dou X, et al.
Purpose The emergence of drug-resistant tuberculosis (DR-TB) represents a threat to the control of tuberculosis. This study aimed to estimate the patterns and trends of DR-TB in patients with suspected DR-TB. In addition, risk factors for multidrug-resistant tuberculosis (MDR-TB)…
Ruesen C, Riza AL, Florescu A, Chaidir L, Editoiu C, et al.
Mycobacterium tuberculosis drug resistance poses a major threat to tuberculosis control. Current phenotypic tests for drug susceptibility are time-consuming, technically complex, and expensive. Whole genome sequencing is a promising alternative, though the impact of different dru…
Tawsifur Rahman, Amith Khandakar, Ashiqur Rahman, Susu M. Zughaier, Muna Al Maslamani, et al.
… and expensive treatments. Moreover, due to the increase of drug-resistant tuberculosis, the disease becomes more challenging in recent years. In this work, a novel deep learning-based framework is proposed to reliably and automatically distinguish TB, non-TB (other lung infectio…
Hameed S, Ahmad SR, Rahman MAU, Nazir H, Ullah I
Objectives Drug-resistant tuberculosis (DR-TB) is a major challenge to national TB control programmes in developing countries. In the Pakistan province of Punjab, the extent and development of DR-TB is not well known. The current study was therefore conducted to assess the incide…
Pedro Gomes, Paulo Paixão, Fernando Maltez, Laura Brum, Jody E Phelan, et al.
…tuberculosis (TB) in Western Europe and, historically, multidrug-resistant (MDR) cases have been strongly associated withstrains pertaining to the endemic Q1 and Lisboa3 clades. Notwithstanding, the contribution of drug resistance-associated allelic configurations in these clades…
Manita Yimcharoen, Sukanya Saikaew, Usanee Wattananandkul, Ponrut Phunpae, Sorasak Intorasoot, et al.
…mains a global health concern because of the development of drug resistance. The adaptability of MTB in response to a variety of environmental stresses is a crucial strategy that supports their survival and evades host defense mechanisms. Stress regulates gene expression, particu…
Callistus A. Akinleye, Adekola O. Adekunle, A. Onabule, Olugbenga Adekunle Olowe, Olusoji Daniel
… tuberculosis has left everlasting scars on people’s lives. Drug-resistant tuberculosis is becoming an increasingly serious hazard to public health. With over 240,000 fatalities due to drug-resistant tuberculosis (DR-TB) worldwide, and Nigeria is one of the 14 nations with a sign…
Balaji Zacharia, Antony Roy
…the increased prevalence of HIV infection. The incidence of drug resistance strains of mycobacterium is also on the rise. When the mycobacterium is resistant to both INH and rifampicin it is called multi drug resistant tuberculosis. There is a primary and an acquired type of drug…
Noorsuzana Mohd Shariff, Shamsul Azhar Shah, Fadzilah Kamaludin
…ients had a significant contribution to the transmission of drug-resistant tuberculosis in the community. However, little is known about the profile of foreign-born drug-resistant patients in Malaysia, and this has become the aims of this current study. Methods and materials: Thi…
Khaoula Balgouthi, Emel Eker, Manaf AlMatar, Osman Albarri, Işil Var
Anti-tuberculosis activity and resistance were recently refocused since clofazimine (CFZ) had a significant therapeutic benefit in treating multi-drug resistant tuberculosis (MDR-TB). We investigate the resistance of CFZ and genetic mutations in drug-resistant Mycobacterium tuber…
Ogari CO, Nyamache AK, Nonoh J, Amukoye E
…as to determine the prevalence of mutations responsible for drug resistance in Mycobacterium tuberculosis among patients visiting selected health centers in Nairobi, Kenya. Methods The cross-sectional study involved 132 TB positive patients visiting Mbagathi and Chandaria hospita…
Dirie AMH, S Çolakoğlu, Abdulle OM, Abdi BM, Osman MA, et al.
…ospital, Mogadishu, Banadir, Somalia; 2Manager of the Multi-Drug Resistant Center in Southern Somalia, Mogadishu, Banadir, Somalia; 3HIV Program manager, Ministry of Health, Somali Federal Government, Mogadishu, Banadir, Somalia; 4Infectious and Microbiology Department, Somalia M…
Oyeniyi Muhammed, Israel Olukayode Popoola, Muhammed Mubashir B Uthman, Ebenezer Obi Daniel, Taiwo Popoola, et al.
… in regions like Nigeria. In this context, the emergence of drug-resistant strains of Mycobacterium tuberculosis poses an escalating challenge. This study aimed to assess awareness of anti-TB drug resistance among TB patients in Kwara State, Nigeria. Utilizing a descriptive cross…
Zhang X, Lam C, Martinez E, Sim E, Crighton T, et al.
…f Mycobacterium tuberculosis harboring mutations conferring resistance can become dominant populations during tuberculosis (TB) treatment, leading to treatment failure. Our understanding of drug-resistant within-host subpopulations and the frequency of resistance-conferring mutat…
A Stoltz, R R Nathavitharana, E de Kock, V Ueckermann, P Jensen, et al.
**BACKGROUND:** Most drug-resistant tuberculosis occurs due to transmission of unsuspected or ineffectively treated drug-resistant tuberculosis. The duration of treatment to stop person-to-person spread of drug-resistant tuberculosis is uncertain. We evaluated the impact of novel…
В. Н. Даниленко
…ssue of the growing morbidity and mortality caused by multi-drug-resistant (extreme drug-resistant) tuberculosis (TB). This issue is aggravated by the alarming rise of immunocompromized patients and immigration worldwide. In order to solve this problem, an interdisciplinary appro…
Bisrat Solomon, Yimtubezinash Woldeamanuel, Tigest Ajeme, Mbazi Senkoro, Tsegahun Manyazewal
**BACKGROUND:** Drug-resistant tuberculosis poses a major global public health threat, with adverse drug reactions complicating treatment and contributing to mortality. In Ethiopia, although many patients with drug-resistant tuberculosis are receiving treatment, studies on advers…
Hilina Mollalign, Dawit Hailu Alemayehu, Kalkidan Melaku, Abaysew Ayele, Dawit Chala, et al.
Globally, drug-resistant tuberculosis (DR-TB) is responsible for 13% of mortality attributable to antimicrobial resistance. In Ethiopia, extrapulmonary tuberculosis (EPTB) is a significant public health challenge, and drug resistance (DR) in EPTB is often overlooked. In a cross-s…
Mesfin EA, Beyene D, Tesfaye A, Admasu A, Addise D, et al.
Background Multidrug drug-resistant tuberculosis (MDR-TB) is a major health problem and seriously threatens TB control and prevention efforts globally. Ethiopia is among the 30th highest TB burden countries for MDR-TB with 14% prevalence among previously treated cases. The focus …
Amyn A. Malik, Mercedes C. Becerra, Hamidah Hussain
…y of TB preventive treatment for persons exposed at home to drug-resistant tuberculosis (DR-TB) [[3]Brooks M N.E. Hussain H. Malik A. Jaswal M. Siddiqui S. Barry Z. Fuad J. Becerra M.C. Seddon J. Furin J. How to care for people exposed to drug-resistant tuberculosis: a practical …
Dadu A, Hovhannesyan A, Ahmedov S, van der Werf MJ, Dara M
…ions, the WHO European Region has the highest proportion of drug-resistant tuberculosis among new and retreated cases. The 18 high-priority countries in eastern Europe and central Asia account for 85% of the tuberculosis incidence and more than 90% of drug-resistant tuberculosis …
Margineanu I, Butnaru T, Lam M, Baiceanu D, Dragomir R, et al.
Background Tuberculosis (TB), and especially its drug resistant forms, is responsible for not only significant mortality, but also considerable morbidity, still under-quantified. This study used four Patient-Reported Outcome Measures (PROMS) to assess the status of persons affect…
Sari Afiah Miyuki Rifani, Zen Ahmad, M. Yusri, Erial Bahar
…esia ranks third in tuberculosis cases, with 23,000 new dualdrug-resistant tuberculosis patients. The delay in predicting tuberculosis resistanceoccurs because sputum tools are not yet available. This study aimed to determinethe differences in chest x-rays for drug-sensitive mult…
Tingting Li
…, significantly compounded by the rising prevalence of multidrug-resistant (MDR-TB) and rifampicin-resistant (RR-TB) strains [1,2]. The cornerstone of effective TB management is timely and accurate diagnosis, yet the current gold standards for detecting drug resistance-molecular …