Showing 51–75 of 200 documents
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M Shahab, E Sturgill, O Okubadejo, T Persaud
…h extrapulmonary involvement in advanced immunosuppression. Drug-resistant Mycobacterium tuberculosis (DR-mTB) further complicates management and worsens prognosis. We present a rare and challenging case of disseminated DR-mTB in a patient with newly diagnosed AIDS, complicated b…
Darja Sadovska
…igh-resolution insights into strain phylogenetic diversity, drug resistance mechanisms, disease transmission dynamics, and recurrence causes. Although WGS offers a promising alternative to widely implemented molecular and culture-based M. tuberculosis analysis methods, further im…
Darja Sadovska
…igh-resolution insights into strain phylogenetic diversity, drug resistance mechanisms, disease transmission dynamics, and recurrence causes. Although WGS offers a promising alternative to widely implemented molecular and culture-based M. tuberculosis analysis methods, further im…
Fred Gordin
…e proportion of tuberculosis patients in the CPCRA who have drug-resistant tuberculosis (TB) and to describe the patterns of drug resistance. SECONDARY: To compare drug resistance data on the Mycobacterium tuberculosis isolates of HIV-infected patients to those of HIV-uninfected…
R k Kumar, A Chakravarty
…men, due to high culture negativity and non-availability of drug susceptibility profile. The emergence of drug-resistant TB, the presence of co-morbidities, or adverse drug reactions (hepatotoxicity) complicates EPTB management. It necessitates testing to ensure comprehensive dru…
Rushna Wazahat, Mehvash Haider, Debasish Chattopadhya, Mridu Dudeja
… and aims: India is a high-burden tuberculosis region and a drug-resistance hotspot. Despite numerous reports of pulmonary tuberculosis (PTB) cases, there needs to be more literature available on the importance of diagnostic methods in the case of extrapulmonary tuberculosis (EPT…
Mahendra Kumar, Ramraju Ambati, Prachi J Urade, Anil H Lotke, Musti Venkata Krishnasastry
**BACKGROUND:** Extrapulmonary tuberculosis (EPTB) constitutes 15%-20% of the entire tuberculosis (TB) cases worldwide. However, the lack of proper diagnostic methods, the absence of a reliable model system, and limited knowledge of its pathogenesis impair therapeutic efficacy an…
Karami-Zarandi M, Bahador A, Gizaw Feysia S, Kardan-Yamchi J, Hasan-Nejad M, et al.
The potentially pathogenic Non-Tuberculosis Mycobacteria (NTM) are emerging nowadays which result in pulmonary and non-pulmonary infections in human. This group of bacteria consists of at least 200 different species. While the pulmonary disease is the most common form of NTM infe…
Selvan Pillay, Margaretha de Vos, Hojoon Sohn, Yonas Ghebrekristos, Tania Dolby, et al.
…r, laboratory decision making on whether widely-used reflex drug susceptibility assays (MTBDR plus , MTBDR sl ) are done on specimens is often based on smear microscopy status. Method We performed receiver operator characteristic (ROC) curve analyses using sputum bacterial load m…
Natalya Karpina, М. А. Колесникова, Irina Shabalina, Olga Gordeeva, Т. Г. Смирнова, et al.
…tural methods (38.7%) (р < 0.05). We obtained results of drug susceptibility testing in 67.9% of cases. TB was caused by drug susceptible MTB in в 68.4% and drug resistant MTB – 31.6% of cases (р < 0.05). Extensive drug resistance was determined in 15.7%, multiple drug resi…
Yajuan Zhou, Jing Wang, Wenjuan Chen, Nan Shen, Yue Tao, et al.
…s 56.07%, and 60 (60/107, 56.07%) patients were infected by drug-resistant M. pneumoniae. Adenovirus was the most prevalent coinfecting organism, accounting for 22.43% (24/107). The classification tree confirmed that viral coinfection was more common in patients younger than 3 ye…
Yajuan Zhou, Jing Wang, Wenjuan Chen, Nan Shen, Yue Tao, et al.
…s 56.07%, and 60 (60/107, 56.07%) patients were infected by drug-resistant M. pneumoniae . Adenovirus was the most prevalent coinfecting organism, accounting for 22.43% (24/107). The classification tree confirmed that viral coinfection was more common in patients younger than 3 y…
Assiut University
…g conditions . TB is a curable and preventable disease. TB drugs are administered in different combinations of four first-line drugs which form the core of treatment regimens in the initial treatment phase of 6-9 months. Several reasons account for the failure of TB therapy such…
Manal Arshad Malik, Aleena Kamran, Dua Ahsan, Aafia Amjad, Sara Moatter, et al.
…outcomes, especially in children, due to delayed diagnosis, drug resistance, and limited diagnostic techniques. **METHODS:** This review provides a comprehensive overview of recent advancements in TBM management and treatment. A systematic search was performed across major datab…
Roof I, Jajou R, Kamst M, Mulder A, de Neeling A, et al.
…clusters are thought to be homogeneous regarding antibiotic resistance. In practice, however, heterogeneous clusters are also identified. This study investigates the prevalence and characteristics of heterogeneous VNTR clusters and assesses whether isolates in these clusters rema…
Nabaneeta Dash, Maura Manion, Sarah L. Silverberg, Ian Kitai
…, and the findings should not be explained by TB relapse or drug resistance, newly acquired infection, expected clinical course or drug side effects. In practice, differentiating these possibilities is often difficult. Incidence The reported frequency of PR in children varies wid…
Beijing Chest Hospital
…as demonstrated promising clinical results in patients with drug-resistant tuberculosis, making it a powerful tool in the fight against drug-resistant tuberculosis. Currently, there is a lack of pharmacokinetic data on contezolid in patients with central nervous system tuberculo…
Venus Marie R Rojas, Michaela Zwyer, Selim Bouaouina, Daniela Brites, Sonia Borrell, et al.
…ly widespread and have been repeatedly associated with multidrug resistance. By comparison, MTBC L1 has received little attention, partially because of its restricted geographical range that mainly includes low- to middle-income countries in South and Southeast Asia, and East Afr…
Ka Pang Chan, MBChB
…o exclude other diseases, low invasiveness and detection of drug resistance. The inability to diagnose TBP early leads to unnecessary invasive pleural procedures and delayed curative treatment. There is a pressing need for a better diagnostic test to diagnose TBP confidently. Wh…
В. Д. Москалюк, T. R. Kolotylo
… lack of changes in the X-ray of the thoracic cavity.
 Drug resistance to one anti-TB drug is significantly more commonly found in the group with the associated infection. The same pattern is noted for subgroup 1 and 3 of HIV/TB.
 The percentage of mortality from infilt…
Young C, Walzl G, Du Plessis N
…settings is unfeasible due to unclear treatment durability, drug toxicity, logistical constraints related to directly observed treatment strategy (DOTS) and the lengthy treatment protocols. Together, these factors promote non-adherence, contributing to relapse and establishment o…
Leonid Lavrenchuk, Tatiana Minogina, Sergey Skornyakov, Diana Vakhrusheva, A Gaida
…dylitis, it is often impossible to obtain information about drug resistance of the pathogen even when examining bone resectates. 418 samples of bone material from 333 patients diagnosed with tuberculous spondylitis were examined. 96 cultures of Mycobacterium tuberculosis were obt…
Yadav S
…sis is commonly seen in endemic countries. Cases of primary drug resistance are rare. There is a paucity of data related to primary drug resistance at extrapulmonary sites. Herein, a case of primary isoniazid mono-resistant extrapulmonary tuberculosis of the multiple right cervic…
Chen Y, Fan L, Ren Z, Yu Y, Sun J, et al.
…S) enables high-performance tuberculosis (TB) diagnosis and drug resistance prediction directly from clinical samples. However, its applicability to paucibacillary TB, including pediatric TB and extrapulmonary TB (EPTB), has been less explored. We aimed to evaluate the performanc…
Shereen Farghaly, Ashraf Zin El-Abdeen, Lamiaa H. Shaaban, Abelmalek Mahmoud
Context Drug-resistant tuberculosis (DR-TB) is a worldwide health problem. Its presence generally reflects poor tuberculosis control. Adequate knowledge about social and epidemiological factors and their interaction is required for its control. Aims To describe incidence, demogra…