Showing 51–75 of 200 documents
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Cui ZJ, Zhang WT, Zhu Q, Zhang QY, Zhang HY
…vaccines, TB has again become a threat because of increased drug resistance. There is still a lack of effective treatment regimens for a person who is already infected with multidrug-resistant Mtb (MDR-Mtb) or extensively drug-resistant Mtb (XDRMtb). In the past decades, many res…
Guo Liang Gan, Matthew H. Nguyen, Elijah Willie, Mohammad H. Rezaie, Brian Lee, et al.
Abstract The efficacy of antibiotic drug treatments in tuberculosis (TB) is significantly threatened by the development of drug resistance. There is a need for a robust diagnostic system that can accurately predict drug resistance in patients. In recent years, researchers have be…
Song T, Li LJ, Liu JL, Geng SJ
… TNF-α in the peripheral blood of patients affected by multidrug-resistant and extensively drug-resistant tuberculosis. Patients and methods 179 patients suffering from tuberculosis treated in the Chest Hospital of Hebei from April 2010 to December 2015 were selected for the stud…
Che Y, Yang T, Lin L, Xiao Y, Jiang F, et al.
Setting: Programmatic management of drug-resistant tuberculosis in Ningbo, China. Objective: To assess whether data-driven genetic determinants of drug resistance patterns could outperform phenotypic drug susceptibility testing in predicting clinical meaningful outcomes among pat…
Olivia Marsha Maritsa, Ni Made Mertaniasih, Ariani Permatasari, Tutik Kusmiati
…the world. This study aims to determine patterns of anti-TB drug resistance in drugresistant TB patients in Dr. Soetomo Academic Hospital from January 2022 to December 2023. This was a descriptive retrospective using patient medical record data in Dr. Soetomo Academic Hospital fo…
Urooj Ahmad, Anab Arshad, Sara Jadoon, Shahana Saba Salih, Hafsa Ahmed, et al.
…research was to find out the demographic characteristics of drug-susceptible and drug-resistant Tuberculosis in Khyber Pakhtunkhwa, Pakistan. Material and Methods: A retrospective survey was conducted on data from the TB Control Program Khyber Pakhtunkhwa recorded between 1st Jan…
Bwire Wilson Bwire, Maurice C Y Mbago, Amina S Msengwa
**BACKGROUND:** The prevalence of tuberculosis (TB) multi-drug resistance is increasing worldwide, including in Tanzania. This trend hinders the attainment of sustainable development goal number three as it increases the number of cases of the disease and treatment costs. Fewer c…
Derner, Catherine Marie
…t challenges to effective treatment due to the emergence of drug-resistant strains. The prevalence and mechanisms of drug resistance amplification in TB remain areas of ongoing research and debate. This study investigated the consequences of suboptimal treatment on the acquisitio…
Christoph Lange, Anca Vasiliù, Anna M. Mandalakas
… increase in the number of individuals identified with multidrug-resistant or rifampicin-resistant tuberculosis has been observed.1WHOGlobal tuberculosis report 2022. World Health Organization, Geneva2022Google Scholar Although a large part of this increase is attributed to impro…
Fizza Mushtaq, Syed Mohsin Raza, Adeel Ahmad, Hina Aslam, Sunia Karam Din, et al.
…nvolves the administration of a panel of five antimicrobial drugs for the period of 6 months. The purpose of this study was to determine antimicrobial drug resistant features of Mycobacterium tuberculosis associated with treatment failure and to determine efficacy of the second l…
Mevlüt Karataş, Tülin Kuyucu, Tülin Sevim
…btained from TB surveillance forms, bacteriology laboratory drug resistance database and octomed patient follow-up program. Results: N=1146 (65.4%) of the cases were male and n=607 (34.6%) were female. The male/female ratio was 1.8 and the highest cases were observed in the 15-24…
Hongkuan Yang, Yahong Cheng, Haoli Ma, Y. Li, Bei Han
Objective: To understand the epidemic status of drug-resistant Mycobacteriun tuberculosis in Xi'an in the past three years, and the impact of COVID-19 epidemic during 2020 so as to provide basic information for local multidrug-resistant tuberculosis (MDR-TB) prevention and treatm…
М.В. Ураксина, Petr Rogozhkin, Ekaterina Eremenko
…ic indicators for tuberculosis, the number of patients with drug-resistant forms of tuberculosis is increasing, which complicates and prolongs the treatment of such patients. The aim of the work is to study the drug resistance of Mycobacterium tuberculosis obtained from surgical …
Khawbung JL, Nath D, Chakraborty S
… tuberculosis continuously evolved to resist the antagonist drugs. This has led to the outbreak of resistant strain that gave rise to "Multi Drug Resistant-Tuberculosis" and "Extensively Drug Resistant Tuberculosis" that can still be cured with a lower success rate. While the mec…
Kidenya BR, Mshana SE, Fitzgerald DW, Ocheretina O
Background Drug resistant Tuberculosis (TB) is considered a global public health threat. Whole-genome sequencing (WGS) is a new technology for tuberculosis (TB) diagnostics and is capable of providing rapid drug resistance profiles and genotypes for epidemiologic surveillance. Th…
Siddharth G. Chatterjee
Background: India has largest population of drug resistant tuberculosis, the treatment of which is long and full of adverse drug reactions. Despite the ongoing research in clinical and pharmacological aspects, quality of life in drug-resistant tuberculosis remains less explored. …
Ogwang MO, Imbuga M, Ngugi C, Mutharia L, Magoma G, et al.
Introduction Globally anti-tuberculosis drug resistance is one of the major challenges affecting control and prevention of tuberculosis. Kenya is ranked among 30 high burden TB countries globally. However, there is scanty information on second line antituberculosis drug resistanc…
Ngula Monde, Mildred Zulu, Mathias Tembo, Ray Handema, Musso Munyeme, et al.
… like many countries in sub-Saharan Africa is affected with drug resistant tuberculosis. However, the drug resistant tuberculosis situation over the years has not been described in various regions of the country. Consequently, this study aims to determine the drug resistant tuber…
Yang J, Lu Y, Chen Y, Wang Y, Wang K
Objective This study aims to analyze the drug resistance spectrum, genetic diversity, and transmission dynamics to provide a basis for the prevention and control of drug-resistant (DR) tuberculosis (TB) epidemics. Methods This retrospective study is based on routine national drug…
Muhammad Novran Chalik, Alif Fathurrachman, Linda Andriani, Rouly Pola Pasaribu, Sudarto, et al.
…on immunity, there are two types of pulmonary TB infection: drug-sensitive and drug-resistant. Based on ATD sensitization tests, MTb resistance types consist of TB that is monoresistant, polyresistant, multidrug resistance (MDR), pre-extensively drug resistant (Pre-XDR), extensiv…
Hasan Ismail Sultan, Ibrahim Khalil Ibrahim
…uberculosis (TB) is an international public health problem. Drug resistant tuberculosis is a considerable global health risk, leading the ongoing TB epidemic and increasing the morbidity and mortality of TB worldwide. Incomplete and insufficient therapeutic regimens can result in…
Natalie E. Nieuwenhuizen, Lei Ji
The standard treatment regime for drug-sensitive TB is two months of therapy with rifampicin (RIF), isoniazid (INH), pyrazinamide (PZA), and ethambutol (EMB), followed by four months treatment with RIF and INH (2) Infection with Mtb strains resistant to RIF and INH is termed mult…
Kateete DP, Kamulegeya R, Kigozi E, Katabazi FA, Lukoye D, et al.
…g cause of morbidity and mortality in developing countries. Drug resistance, a huge problem in this contagious disease, is driven by point mutations in the Mycobacterium tuberculosis genome however, their frequencies vary geographically and this affects applicability of molecular…
Jin C, Wu Y, Chen J, Liu J, Zhang H, et al.
…ence of resistant Mycobacterium tuberculosis (MTB) strains. Drug-resistant TB, including mono-drug-resistant TB, multidrug-resistant TB (MDR-TB), and extensively drug-resistant TB (XDR-TB), presents significant public health challenges. Methods We conducted a systematic literatur…
Al Mahrouqi S, Gadalla A, Al Azri S, Al-Hamidhi S, Al-Jardani A, et al.
…ulation. The present study examined the genetic profile and drug resistance-conferring mutations in Mycobacterium tuberculosis collected from Omanis and expatriates to recognise possible causes of disease transmission. Methods We examined M. tuberculosis cultured positive samples…