Showing 51–65 of 65 documents
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Susanna S van Wyk, Marriott Nliwasa, F. Lu, Chih-Chan Lan, James A. Seddon, et al.
<sec> <title>BACKGROUND</title> Finding individuals with drug-resistant tuberculosis (DR-TB) is important to control the pandemic and improve patient clinical outcomes. To our knowledge, systematic reviews assessing the effectiveness, cost-effectiveness, acceptability, and feasib…
Oriekot Anthony, Senai Goitom Sereke, Felix Bongomin, Samuel Bugeza, Zeridah Muyinda
Abstract Background: Tuberculosis (TB) is one of the leading causes of death worldwide. Radiology has an important role in the diagnosis of both drug-sensitive (DS) and drug-resistant (DR) pulmonary TB (PTB). This study aimed at comparing the chest x-ray (CXR) patterns of microbi…
Tijani Sulaimon
We demonstrate not only that sensitivity and specificity by themselves offer a limited view into the performance of a test, but also that these metrics are not intrinsic to a test, but vary with disease prevalence.More generally, the contextual 'spectrum of disease' -which, in pr…
Naveen Pandhi, Ritu Dadra, Balbir Malhotra, Dr. P Prasanth
This is an observational prospective study, which included 200 microbiologically confirmed cases of tuberculosis (TB) which came to outpatient department or got admitted in the wards. Clinico-diagnostic profile of these cases was determined. The collected data were documented, co…
Ismaheel O. Lawal, Bernard Fourie, Matsontso Mathebula, Ingrid Moagi, Thabo Lengana, et al.
296 Background: FDG PET/CT imaging at the completion of anti-tuberculosis therapy (ATT) may show residual metabolically activity (RMA) in patients considered cured at end of treatment (EOT) based on current standard of care diagnostic definitions. The significance of RMA as a ris…
Jamal Hassan Mohamoud
… of decentralized and community-based care, rapid molecular diagnostics, multimodal adherence support, shorter all-oral DR-TB regimens, and integration of TB services with nutrition and humanitarian support. Strengthening health system resilience and prioritizing vulnerable popul…
Benjamin WYPLOSZ, Ph
The objective of the present study is to confirm in a multicentric study the utility of our viability test in large cohort of smear-positive pulmonary tuberculosis patients under treatment and to determine if the test could help physicians to discontinue isolation measures in hos…
Susan Shin-Jung Lee, MD, PhD
Tuberculosis remains an important global health problem, and the world is currently not on track to end the TB epidemic by 2030. With the concerted efforts of the government and medical community, the incidence of TB in Taiwan has gradually decreased, however, Taiwan remains an e…
Otsuka Pharmaceutical Development & Commercialization, Inc.
This trial will assess the safety and efficacy of OPC-167832 combined with delamanid and bedaquiline in participants with drug-susceptible tuberculosis (DS-TB) administered for 17 weeks compared to rifampin, isoniazid, ethambutol, pyrazinamide (RHEZ) administered for 26 weeks. E…
University of Virginia
Individual pharmacokinetic variability is an important driver of tuberculosis (TB) treatment failure particularly among undernourished populations, and that suboptimal serum drug concentrations are associated with delayed response to treatment, death, and acquired bacterial drug …
Bahirdar University
The study might come up with valuable findings to address poor treatment outcome, poor quality of life, disability score and depressive symptoms. The findings may also be decreased health professional workload. The findings would be supportive evidences for policy makers, program…
Karki M, Kantipudi K, Yang F, Yu H, Wang YXJ, et al.
Classification of drug-resistant tuberculosis (DR-TB) and drug-sensitive tuberculosis (DS-TB) from chest radiographs remains an open problem. Our previous cross validation performance on publicly available chest X-ray (CXR) data combined with image augmentation, the addition of s…
Menonli Adjobimey, Anete Trajman, Mayara Lisboa Bastos, Chantal Valiquette, Diana Gibson, et al.
**BACKGROUND:** The World Health Organization recommends evaluation of all household contacts (HHC) of index tuberculosis (TB) patients for TB disease (TBD) and TB infection (TBI). Tests to identify TBI and TBD are preferred but can be skipped in persons living with HIV and child…
Geliukh E, Nabirova D, Davtyan K, Yesypenko S, Zachariah R
Introduction We assessed the influence of a result-based financing (RBF) model, which included incentives for Primary Healthcare facilities on TB treatment outcomes. Methodology We compared TB patients > 17 years and their treatment outcomes among those who did and did not benefi…
Shanghai Pulmonary Hospital, Shanghai, China
\# Brief Summary This study aims to evaluate the early bactericidal activity (EBA), safety, and tolerability of 4-month short-course regimens containing bedaquiline, moxifloxacin, and pyrazinamide in patients with drug-susceptible tuberculosis. This is a prospective, randomized,…