Showing 51–75 of 192 documents
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Millard JD, Mackay EA, Bonnett LJ, Davies GR
… Methods We will search for randomised and quasi-randomised clinical trials in adult participants with and without the inclusion of PZA in TB treatment regimens in the Cochrane infectious diseases group's trials register, Cochrane central register of controlled trials (CENTRAL), …
Hills NK, Lyimo J, Nahid P, Savic RM, Lienhardt C, et al.
…osis (TB). However, the current practice in TB therapeutics trials is to use composite binary outcomes, which in the absence of standardization may inflate false positive and negative errors in evaluating regimens. The lack of standardization of outcomes is a barrier to the ident…
Xie F, Duan Z, Zeng W, Xie S, Xie M, et al.
… 159 CAP patients to assess the diagnostic performance of a clinical metagenomics assay and its impact on clinical management and patient outcomes. When compared to other techniques, clinical metagenomics detected more pathogens in more CAP cases, and identified a substantial num…
Ye Q, Wang H, Xia X, Zhou C, Liu Z, et al.
…ls (DPSCs) in treating severe pneumonia caused by COVID-19. Trial design This is a single centre, two arm ratio 1:1, triple blinded, randomized, placebo-controlled, parallel group, clinical trial. Participants Twenty serious COVID-19 cases will be enrolled in the trial from April…
Rudolf F, Abate E, Moges B, Mendes AM, Mengistu MY, et al.
Background The Bandim TBscore is a clinical score that predicts treatment outcome in Tuberculosis (TB) patients and proved useful as an indicator of which healthcare-seeking adults to refer for sputum smear microcopy. We aimed to test in a randomized trial if the TBscore could be…
Human Sciences Research Council
…his pragmatic, open-label, individual randomised controlled trial was done in nine clinics in Johannesburg, South Africa. Participants (aged ≥18 years) undergoing investigation for tuberculosis were randomly assigned (1:1) to the intervention group or control group (standard of c…
Jagannath Purushothama
…ebo controlled, block- randomized, double-arm, single blind trial will be experimented between March 2019 and August 2022 in Mangaluru, India, with a sample size of 300 in both the arms. The intervention group will be prescribed with nicotine polacrilex chewing gums along with br…
Yoshihiro Kanemitsu, Motohiko Suzuki, Kensuke Fukumitsu, Takamitsu Asano, Norihisa Takeda, et al.
…indicators of Th2-driven inflammation in the lower airways. TRIAL REGISTRATION: This study was registered on the UMIN Clinical Trials Registry (Registry ID UMIN000018672).
Chang Liu, Xin Wang, Yue Wang, Yuanyu Zhao, Huiwen Guan, et al.
…he anesthesia management of double-lumen endotracheal tube. Trial registration : This clinical research was registered at the Chinese Clinical Trial Registry(www.chictr.org.cn,ChiCTR2000040188).
J. Nancy Hilda, Gopalan Narendran, Banu Rekha VV, Elizabeth Hanna Luke, Ponnuraja Chinnaiyan, et al.
…our to prevent mortality caused by this co-infection. <bold>Clinical trial registration:</bold> Two studies were registered with the Clinical Trial Registry (CTRI 2008/091/000024 & NCT00933790).
Xiao Li, Li Wen, Lianjie Sun, Junyi Ren, Ying Xu, et al.
… dysfunction. Reducing pulmonary inflammation and improving clinical symptoms is the focus of current treatment. Low-intensity pulsed ultrasound (LIPUS) can mitigate inflammation and inhibit edema formation. We aimed to investigate the efficacy of therapeutic LIPUS in improving l…
Xiong K, Cai J, Liu P, Wang J, Zhao S, et al.
…ug-induced liver injury in animal experiments. However, the clinical evidence is absent. The objective is to investigate the effect of adjunctive Lactobacillus casei on tuberculosis-drug-induced liver injury. Methods and results A post hoc analysis is conducted for a previous ran…
Shivalli S, Hondappagol A, Akshaya KM, Nirgude A, Varun N, et al.
…This is a pragmatic, prospective, non-randomised controlled trial in two pairs of RNTCP Designated Microscopy Centres (located at secondary and primary healthcare facilities) of Dakshina Kannada district, India. Presumptive pulmonary TB patients aged ≥18 years will be included. W…
Jahnke N, Waters V, Ratjen F, Smith S, Hambleton IR, et al.
…(CF). Search methods We searched Cochrane's Cystic Fibrosis Trials Register, online databases (MEDLINE, Embase and PubMed) and online trials registries (www. Clinicaltrials gov and the World Health Organization International Clinical Trials Registry). We also searched the referen…
Geetanjali Chander, Nishi Suryavanshi, Nikhil Gupte, Gauri Dhumal, Shatabdi Bagchi, et al.
…outcomes. This paper describes the protocol for HATHI,ybrid trial forlcohol reduction among people withB andIV inndia, a Hybrid Type 1 effectiveness-implementation trial, that tests if a behavioral intervention integrated into TB and HIV treatment, compared to usual care, results…
Karikalan Nagaraj, Bella Devaleenal Daniel, Chandra Suresh, Dhanalakshmi Angamuthu, Shobana Palanisamy, et al.
…based interventions under the National TB program of India. Clinical trial registration The study has been registered in the Clinical Trial Registry of India CTRI/2024/05/066847.
Yadav B, Rai A, Mundada PS, Singhal R, Rao BCS, et al.
…tions in cases suffering with long term effects of COVID 19 TRIAL DESIGN: Multi-centric, randomized, controlled, parallel group, open-label, exploratory study. The study duration is 9 months and the intervention period is 90 days from the day of enrolment of the participant. Part…
Kohei Fujita, Yutaka Ito, Yuki Yamamoto, Osamu Kanai, Takuma Imakita, et al.
…ormer had more localized lung inflammation than the latter. Trial registration : This trial was prospectively registered in the Clinical Trials Registry (UMIN 000027652).
Kohei Fujita, Yutaka Ito, Yuki Yamamoto, Osamu Kanai, Takuma Imakita, et al.
…ormer had more localized lung inflammation than the latter. TRIAL REGISTRATION: This trial was prospectively registered in the Clinical Trials Registry (UMIN 000027652).
Nazir Ismail, Harry Moultrie, Judith Mwansa-Kambafwile, Andrew Copas, Alane Izu, et al.
…his pragmatic, open-label, individual randomised controlled trial was done in nine clinics in Johannesburg, South Africa. Participants (aged ≥18 years) undergoing investigation for tuberculosis were randomly assigned (1:1) to the intervention group or control group (standa…
Sumari-de Boer M, Pima FM, Ngowi KM, Chelangwa GM, Mtesha BA, et al.
…reatment outcome. We propose a pragmatic cluster randomized trial to investigate the effectiveness of evriMED with reminder cues and tailored feedback on adherence to TB treatment in Kilimanjaro, Tanzania. Methods/design We will create clusters in Kilimanjaro based on level of he…
Khan S, Shahzadi A
… search of PubMed, the Cochrane Central Register of Control Trials, Science Direct, and Clinical Trials Registry (ClinicalTrials.gov), encompassing the period between 2000 and 2017, was conducted in accordance to PRISMA guidelines. Seven studies were identified. Collectively, the…
Steven Taylor, Kerry L. Ivey, Peter G. Gibson, Jodie L. Simpson, Geraint B. Rogers
… in adults with persistent symptomatic asthma in the AMAZES trial (Australian and New Zealand Clinical Trials Registry (ANZCTR), number 12609000197235) [1]. However, response to treatment was variable between participants and the characteristics of those who experience most clini…
Bethou Adhisivam, Chinnathambi Kamalarathnam, B Vishnu Bhat, Kumutha Jayaraman, Siva P Namachivayam, et al.
… **DESIGN:** Multicentre, open label, randomised controlled trial SETTING: Three tertiary neonatal intensive care units (NICUs) in southeast India. **POPULATION:** Newborn babies weighing <2000 g. 7067 were assessed for eligibility and 5420 were randomised (2714 BCG-OPV, 2706 co…
Bhargava A, Bhargava M, Velayutham B, Thiruvengadam K, Watson B, et al.
…. We designed an open-label, field-based cluster randomised trial to assess the impact of nutritional supplementation (with food rations) on TB incidence in a group at higher risk of TB infection and disease, viz household contacts (HHC) of patients with microbiologically confirm…