Showing 51–75 of 129 documents
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Tsang CA, Shah N, Armstrong LR, Marks SM
…8-24 month regimen) for patients without extrapulmonary TB, pregnancy, a previous second-line TB medication exposure, or drug resistance to pyrazinamide, ethambutol, kanamycin, moxifloxacin, ethionamide, or clofazimine. The recommendation was based on successful clinical trials c…
Adejumo OA, Olusola-Faleye B, Adepoju VA, Gidado M, Onoh MO, et al.
…id function tests, serum electrolyte, haemoglobin level and pregnancy test) of DR-TB patients initiated on treatment in Lagos, Nigeria between 1 August 2014 and 31 March 2017 were reviewed. Results A total of 565 DR-TB patients' laboratory records were reviewed, of which 397 (70.…
Angella Musiimenta, PhD
… The use of mobile money for saving and making payment for pregnancy-related care was beneficial and feasible among pregnant women in Madagascar. Among hard-to-reach populations, mobile money has helped enable routine payment of health insurance and improve access to family plan…
Iglesias E, Bayona-Bafaluy MP, Pesini A, Garrido-Pérez N, Meade P, et al.
… phosphorylation-inhibiting pharmaceuticals provided during pregnancy when dopaminergic neuronal differentiation is taking place.
Ieuan Evans, Aaron Weimann, Timothy Baird, Charles Haworth, R. Andrés Floto
… %) of the pwCF, with two not commencing treatment owing to pregnancy and psychological issues respectively. Analysis of the treatment outcomes for 39 pwCF was conducted (one subject was excluded as they had only been on treatment for 3 months at the time of data collection). Of …
Lorenzo Guglielmetti, Uzma Khan, GE Velasquez, Maëlenn Gouillou, Nathalie Lachenal, et al.
…ptibility to fluoroquinolones Participants aged 15 years No pregnancy, allergy or resistance to study drugs, severe lab abnormalities or cardiac risk factors 12 sites 754 participants
Anila Basit, Wajeeeha Syed, Nadia Ashiq Hussain, Muhammad Nasir, Laraib Aurangzeb
… been shown to negatively affect mothers and infants during pregnancy, labor, and the postpartum period. Objective: This Study aimed to determine the frequency of gynecological issues among women receiving therapy for multidrug-resistant T.B. Materials and Methodology: The Obstet…
Alladi Mohan
…ent chapters. Treatment of TB in special situations such as pregnancy and underlying renal and hepatic diseases, including case-based approach, is covered in the ensuing chapters. The principles of management of multidrug-resistant TB (MDR-TB) and rifampicin-resistant TB (RR-TB) …
Andreea Amuzescu, Mircea Tampa, Dorin Ionescu
…paresis due to peripartum hypoxia subsequent to a gemellary pregnancy, coexisting with seizures (under treatment with sodium valproate), intravenous drug abuse since childhood, chronic hepatitis C virus (HCV) infection and human immunodeficiency virus (HIV) infection. Numerous ho…
Anand Kumar, Aparjot Singh, Sudhir Chaudhri, Sanjay Kumar Verma, Kiran Pandey, et al.
…tients’ section of the hospital at random. After ruling out pregnancy, the endometrial samples were collected from premenstrual endometrium (approximately 2-3 days before menstruation) and were subjected to histopathological examination and CBNAAT. Day 1 or 2 menstrual blood of u…
Frédérique Chammartin, Cam Ha Dao Ostinelli, Kathryn Anastos, Antoine Jaquet, Ellen Brazier, et al.
…ated comorbidities and coinfections and (iv) to examine the pregnancy-related and HIV-related outcomes of women on ART and their infants exposed to HIV or ART in utero or via breast milk. PARTICIPANTS IeDEA is organised in four regions (Central, East, Southern and West Africa), w…
Frédérique Chammartin, Cam Ha Dao Ostinelli, Kathryn Anastos, Antoine Jaquet, Ellen Brazier, et al.
…ed comorbidities and co-infections, and (iv) to examine the pregnancy- and HIV-related outcomes of women on ART and their infants exposed to HIV or antiretroviral therapy in utero or via breastmilk. Participants IeDEA is organized in four regions (Central, East, Southern and West…
Anthony Garcia-Prats, MD, Ethel Weld, MD
This study will evaluate the pharmacokinetics, safety, and tolerability of the anti-tuberculosis (TB) drug delamanid (DLM) in combination with an optimized multidrug background regimen (OBR) for multidrug-resistant tuberculosis (MDR-TB) in HIV-infected and HIV-uninfected children…
Anneke Hesseling, M.D., Ph.D.
P1108 was a Phase I/II, open-label, single-arm, exposure-controlled dose finding study of BDQ in infants, children, and adolescents living with and without HIV, with clinically diagnosed or bacteriologically confirmed rifampin-resistant tuberculosis (RR-TB). The study was designe…
Rodney Dawson, MD
The purpose of this study is to assess the mycobactericidal activity of the moxifloxacin plus PA-824 plus pyrazinamide regimen after 8 weeks of treatment.
Andreas H Diacon, MD, PhD, Kelly Dooley, MD, PhD
Isoniazid (INH) is a drug commonly used to treat tuberculosis (TB) worldwide. Sometimes, the bacteria that cause TB can become resistant to INH. Resistance means that bacteria have adapted to a drug and are able to live in the presence of the drug. When TB becomes resistant to IN…
Gavin Churchyard, MBBCh MMed FRCP FCP(SA) PhD, Amita Gupta, MD, MHS, Anneke Hesseling, MD, PhD, Susan Swindells, MBBS
The purpose of this study is to compare the efficacy and safety of 26 weeks of delamanid (DLM) versus 26 weeks of isoniazid (INH) for preventing confirmed or probable active tuberculosis (TB) during 96 weeks of follow-up among high-risk household contacts (HHCs) of adults with mu…
Asan Medical Center
The objective of this study is to analyze the efficacy of a new regimen using Bedaquiline, Pretomanid, Linezolid, and Moxifloxacin for 24 weeks or Bedaquiline, Pretomanid, Linezolid for 26 weeks for the treatment of MDR/RR-TB through the clinical trial. The BPaL (Bedaquiline, Pr…
Clifton E Barry, Ph.D.
This study will evaluate the effect of adding metronidazole to standard second-line therapy for tuberculosis in patients who have multi-drug resistant tuberculosis (MDR-TB) of the lungs. It will evaluate the safety and tolerability of metronidazole in combination with antitubercu…
Kelly Dooley, MD
The overall goal of this exploratory proof-of-concept study is to determine whether, in participants with pulmonary tuberculosis caused by M. tuberculosis (MTB) with or without rifampin resistance-conferring rpoB-gene mutations, the combination of meropenem and amoxicillin/clavul…
Otsuka Pharmaceutical Development & Commercialization, Inc.
The purpose of this study is: * To evaluate the safety and tolerability of orally administered OPC-67683 when administered two times daily to MDR tuberculosis (TB) participants refractory to treatment with an optimized background regimen of anti-TB medications (OBR). * To evalua…
Mareike Rabe, Jennifer A Hughes
Tuberculosis (TB), particularly drug-resistant TB (DR-TB), remains a major public health concern in South Africa (SA), with children, adolescents, and pregnant and postpartum women (CAPPW) facing heightened risks because of biological and social vulnerabilities. This article high…
Kelly E. Dooley, MD, PhD
Tuberculosis (TB) is a global public health concern and developing new treatment regimens is an important research priority. PA-824 is an experimental TB medication. This study will evaluate the safety and tolerability of PA-824 when combined with efavirenz (EFV) or ritonavir-boo…
Aishwarya Venkataraman, MRCPCH
Bacille Calmette Guerin (BCG) vaccine is one of the most used vaccines of the world, to reduce the risks of natural tuberculous infection. The efficacy of BCG vaccination in newborns is well known and has a documented protective effect against meningitis and disseminated TB in ch…
Acquah R, Mohr-Holland E, Daniels J, Furin J, Loveday M, et al.
This brief report presents a series of 5 pregnant women treated for rifampicin-resistant tuberculosis with the novel drugs bedaquiline, delamanid, and linezolid as part of an optimized backbone regimen and reviews the outcomes of the children born to them. Although the case serie…