Showing 26–50 of 200 documents
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Somen Saha, Devang Raval, Deepak Saxena, Nishad Halkarni, Rahul Doshi, et al.
Abstract Background Drug-sensitive tuberculosis (DSTB) patients often face challenges in adhering to medications. Tuberculosis Monitoring Encouragement Adherence Drive (TMEAD)is an electronic cartridge-based dispensing module that dispenses patients’ daily dose in a small disposa…
Jeong D, Kim J, Lee SW, Choi H, Sohn H, et al.
Despite a steady decline in incidence, tuberculosis (TB) remains a substantial public health burden in Korea, particularly among older adults. Existing national TB surveillance systems lack sufficiently comprehensive data to assess long-term outcomes and health disparities. The K…
Chiwook Chung, Seung Won Lee, Dawoon Jeong, Hongjo Choi, Hojoon Sohn, et al.
…ment persists regarding the cause of death in patients with tuberculosis (TB) between the national TB registry and vital registration statistics. This study investigated the disagreement and contributing factors between TB-related and non-TB-related deaths using an integrated nat…
Zhang P, Shi H, Xie Y, Liang J, Hu Q, et al.
Background The coexistence of tuberculosis (TB) and type 2 diabetes mellitus (DM) presents unique challenges in treatment optimization and management, given the mutual exacerbation of disease processes. Objective This multicenter, open-label, randomized controlled trial aims to e…
Osman M, van Schalkwyk C, Naidoo P, Seddon JA, Dunbar R, et al.
…V treatment eligibility criteria were expanded to allow all tuberculosis (TB) patients lifelong ART. The impact of this change on TB mortality in South Africa is not known. We evaluated mortality in all adults (≥ 15 years old) treated for drug-susceptible TB in South Africa betwe…
Freimane L, Kivrāne A, Ulanova V, Vīksna A, Sevostjanovs E, et al.
Biomarker research characterising the effect of anti-tuberculosis (TB) chemotherapy on systemic body response is still limited. In this study, we aimed to investigate fluctuations in circulating cell-free mitochondrial DNA (ccf-mtDNA) and circulating cell-free nuclear DNA (ccf-nD…
Ki MS, Jeong D, Kang HY, Choi H, Sohn H, et al.
…kground The fixed-dose combination (FDC) for first-line antituberculosis (TB) treatment has long been a standard practice worldwide; however, there is limited evidence on whether the use of FDC improves long-term treatment outcomes in the real-world setting. Methods We identified…
Araújo-Pereira M, Nogueira BMF, Spener-Gomes R, Carvalho ACC, Sant'Anna FM, et al.
Background Tuberculosis (TB) remains a major plague of humanity. People with TB (PWTB) are commonly anemic. Here, we assessed whether the severity of anemia in PWTB prior to anti-TB treatment (ATT) was a risk factor for an unfavorable outcome. Methods Patients ≥ 18 years old with…
Alfi Nurul Islamiyah, Syarifuddin Syarifuddin, Morsalina Akhsa, Iis Rukmawati, Eni Margayani, et al.
Tuberculosis (TB) remains a significant global health concern, particularly in Indonesia. Ensuring rational TB treatment is crucial for effective disease control and preventing the emergence of drug resistance. This study aimed to evaluate the rationality of TB treatment among ne…
Hassane-Harouna S, Gils T, Decroo T, Ortuño-Gutiérrez N, Delamou A, et al.
Directly observed treatment (DOT) for tuberculosis (TB) is recommended by the World Health Organization. However, DOT does not always meet patients' preferences, burdens health facilities, and is hard to implement in settings where access to healthcare services is regularly inter…
Ruchita A Sakaria, Bina Modi, Anjana MS, Bharti Koria, Kamlesh Vithalani
Introduction: Drug-resistant tuberculosis (DR-TB) poses a significant public health challenge in India. While treatment success in DR-TB cases remains limited, bedaquiline-based oral longer regimens have shown promising results in select studies. Objective: This study aimed to ev…
Kalva J, Babu SP, Narasimhan PB, Raghupathy K, Ezhumalai K, et al.
Background Tuberculosis (TB) is well-known for causing wasting. Patients on treatment gain weight and weight loss is associated with unfavorable treatment outcomes. There is limited description of weight loss and its predictors during intensive treatment phase. The objective of t…
Shah D, Bhide S, Deshmukh R, Smith JP, Kaiplyawar S, et al.
…ulated areas in the world and is a major contributor to the tuberculosis (TB) epidemic in India. A test and treat approach for TB infection (TBI) amongst household contacts (HHC) is part of the national policy for TB preventive treatment (TPT). However, in practice, the use of in…
Rebecca Thomas, Nicola L Harman, Paula R Williamson, Laura Bonnett, Geraint R Davies, et al.
**BACKGROUND:** The global burden of tuberculosis (TB) remains high, and treatment of both drug-susceptible and drug-resistant diseases is complex and prolonged. International clinical trial networks and public-private partnerships are beginning to deliver advances in TB treatmen…
Megerso A, Deyessa N, Jarso G, Worku A
…Three of the eight hospital patients were on drug resistant tuberculosis (TB) treatment. Sixty two codes, five code categories and three themes emerged from the interviews. The three themes were health system, stigma and discrimination, and socioeconomic problem related experienc…
Argita D. Salindri
The global strategy to end tuberculosis (TB) includes interim goals to reduce TB incidence by 80% and TB mortality by 90% by the end of 2030. However, global TB control primarily focuses on achieving favorable TB treatment outcomes (i.e., microbial cure or treatment completion). …
Adisa R, Ayandokun TT, Ige OM
Background Tuberculosis (TB) remains one of the most common infectious diseases worldwide. Although TB is curable provided the treatment commenced quickly, appropriately and uninterrupted throughout TB treatment duration. However, high default rate, treatment interruption and the…
Shivakoti R, Dalli J, Kadam D, Gaikwad S, Barthwal M, et al.
Individuals with concurrent tuberculosis (TB) and Type 2 diabetes (DM) have a higher risk of adverse outcomes. To better understand potential immunological differences, we utilized a comprehensive panel to characterize pro-inflammatory and pro-resolving (i.e., mediators involved …
Collins Timire, Rein M G J Houben, Debora Pedrazzoli, Rashida A. Ferrand, Claire Calderwood, et al.
Introduction: Tuberculosis (TB) disproportionally affects poor people, leading to income and non-income losses. Measures of socioeconomic impact of TB, e.g. impoverishment and patient costs are inadequate to capture non-income losses. We applied impoverishment and a multidimensio…
Pranay Sinha, Madhavi Bhargava, Madolyn R Dauphinais, Madeline E Carwile, C Robert Horsburgh, et al.
**BACKGROUND:** Undernutrition is the leading cause of tuberculosis (TB) globally, but nutritional interventions are often considered cost-prohibitive. The RATIONS study demonstrated that nutritional supplementation to household contacts of persons with TB can reduce TB incidence…
Muhammed S Bah, Kyaw Ko Ko Htet, Gregory P Bisson, Celso Khosa, Refiloe Masekela, et al.
Tuberculosis (TB) remains a major public health issue across the world and national TB guidelines are an important resource for diagnosis and treatment. This scoping review aimed to analyze how countries with the highest TB burdens approach the integration of comorbidity and risk…
Timire C, Houben RMGJ, Pedrazzoli D, Ferrand RA, Calderwood CJ, et al.
Tuberculosis (TB) disproportionally affects poor people, leading to income and non-income losses. Measures of socioeconomic impact of TB, e.g. impoverishment and patient costs are inadequate to capture non-income losses. We applied impoverishment and a multidimensional measure on…
Kusmiati T, Burhan E, Sugiyono RI, Arlinda D, Naysilla AM, et al.
…nary histoplasmosis can occur simultaneously with pulmonary tuberculosis (TB) or as an alternative diagnosis in clinically-diagnosed TB patients with no microbiological evidence of TB. This study aimed to determine the seroprevalence of anti-H. capsulatum IgG antibody among pulmo…
Sarita Mukura, Parinya Ruenwilai
**OBJECTIVES:** First-line anti-tuberculosis (TB) medications are effective for drug-susceptible TB but are commonly associated with hepatotoxicity, which can compromise treatment adherence and contribute to drug resistance. This study aimed to determine the frequency of anti-TB …
Kivrane A, Ulanova V, Grinberga S, Sevostjanovs E, Viksna A, et al.
…). However, the effect of genetic polymorphisms on the anti-tuberculosis (anti-TB) drug, and particularly rifampicin (RIF), exposure or anti-TB drug-induced liver injury (DILI) remains uncertain. Here, we evaluated the relationship between single nucleotide polymorphisms (SNPs) d…