Showing 1–25 of 200 documents
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Olanisun P Adewole, MD, Bolanle A Omotoso, MD
Tuberculosis (TB) is caused by mycobacterial organism. It is the leading infectious disease cause of death globally, with more than 10 million new cases and over 2 million deaths annually. Developing countries bear the greatest brunt of the disease. The long duration of current t…
E. E. Lesnik, S. Ginda
…ers of cellular, humoral immunity and natural resistance in tuberculosis patients with primary and acquired multiple drug resistance; to study the correlation of these parameters with clinical and radiological manifestations. Subjects and Methods. A prospective study was conducte…
Álvaro H Borges, Marisa Russell, Dereck Tait, Thomas J Scriba, Elisa Nemes, et al.
**BACKGROUND:** People with tuberculosis who complete treatment remain at risk of recurrent disease. The vaccine H56:IC31 has been shown to be safe and immunogenic in phase 1 and 2 studies, but whether it can reduce the risk of tuberculosis recurrence is unknown. **METHODS:** In…
Jannat Nabaziwa, Eustes Kigongo, Amir Kabunga, Walter Acup, Sean Steven Puleh
Uganda has a high incidence of tuberculosis infection at 200 cases per 100,000 people. With effective therapy and adherence to medications is essential for reducing the spread of tuberculosis in the community. However, many of the initiated patients do not get to finish the entir…
Vaidehi Mehta, Ramsha Ansari, Ira Shah
Mixed tuberculosis occurs with multiple clonally distinct mycobacterium tuberculosis strains in an individual. We present a 12-year-old girl with steroid-resistant nephrotic syndrome and drug-sensitive pulmonary tuberculosis (Xpert MTB/Rif) and preextensively drug-resistant tuber…
Mvungi HC, Mbelele PM, Mbelele PM, Buza JJ, Mpagama SG, et al.
Background Human tuberculosis is a chronic inflammatory disease caused by mycobacterium tuberculosis. Pulmonary tuberculosis is the result of the failure of host immune system to control mycobacterium tuberculosis. The aim of the study was to asses the changes of the cytokines in…
Qian Zhai, Xianglong Kong, Qian Li, Na Yang
…40) levels are associated with drug-resistant Mycobacterium tuberculosis in children with pulmonary tuberculosis. **METHODS:** In this prospective observational study, 235 pediatric pulmonary tuberculosis patients treated at Hebei Provincial Chest Hospital from February 2021 to …
Shaki Aktar
The prevalence of tuberculosis (TB) is reducing in Bangladesh, but the emergence of drug resistant tuberculosis make the TB control effort more challenging and questionable. The present study aimed to identify the socio-demographic, behavioral and clinical risk factors for develo…
Saha S, Saxena D, Raval D, Halkarni N, Doshi R, et al.
Introduction Adherence to tuberculosis (TB) medication is one of the critical challenges to tuberculosis elimination in India. Digital adherence technologies (DAT) have the potential to facilitate medication adherence and monitor it remotely. Tuberculosis Monitoring Encouragement…
Debdeep Mitra, P. Sanyal, Divya Kamboj, Rakesh Kumar Deepak, Sayan Chakraborty, et al.
…way in suppression of T cell response against Mycobacterium tuberculosis (M.tb) among tuberculosis (TB) patients. Here, we checked the status of host immune response among the drug resistant (DR) and Drug Sensitive (DS) tuberculosis (TB) patients. Additionally, in a phase I/ II c…
Cintron C, Dauphinais M, Fiogbe AA, Dogo MF, Ate S, et al.
Introduction Undernourished persons with tuberculosis (TB) (PWTB) are at increased risk of mortality, treatment failure and relapse. Nutritional support for PWTB has the potential to mitigate the risk of undernutrition. However, given ethical concerns, well-powered randomised con…
World Health Organization
This web annex to the WHO consolidated guidance on tuberculosis data generation and use provides practical examples illustrating how tuberculosis (TB) diagnosis, treatment initiation and treatment outcomes should be recorded and reported within TB surveillance systems. Using a se…
Somoskovi A, Salfinger M
In 2019, tuberculosis is still a global source of morbidity and mortality. To determine and provide the most effective treatment regimen to patients, the tuberculosis laboratory needs to rapidly but reliably answer 2 main questions: (1) Is Mycobacterium tuberculosis detectable in…
Putri Immi Rizky Budiyani, Ratna Djuwita, Renti Mahkota, Dwi Handayani
Tuberculosis and HIV are serious health issues that can significantly impact an individual's immune system by evading immune monitoring functions. Research on TB-HIV treatment success, especially in DKI Jakarta province, is still limited. This study aims to assess the treatment s…
Abhinav Pandey, Abhijeet, Rajendra Pal Singh, Palak Goyal, Huma Khan, et al.
…duction: Despite being a fully treatable infectious disease,tuberculosis remains among the major causes of death. Earlydiagnosis and antibiotic treatment are essential for stopping thespread of TB. Treatment is now more challenging and expensivedue to the emergence of drug-resist…
Apolisi I, Cox H, Tyeku N, Daniels J, Mathee S, et al.
…th household exposure to multidrug- or rifampicin-resistant tuberculosis (MDR/RR-TB) are at high risk of developing TB disease. Tuberculosis preventive therapy (TPT) is recommended, but programmatic experience is limited, particularly for adolescents. Methods We conducted a prosp…
Tait D, Diacon A, Borges ÁH, van Brakel E, Hokey D, et al.
Background H56:IC31 is a candidate vaccine against tuberculosis (TB) with the potential to reduce TB recurrence rate. It is thus important for future clinical trials to demonstrate safety and immunogenicity of H56:IC31 in individuals treated for TB. Methods Twenty-two adults conf…
Styliani Karanika, Tianyin Wang, Addis Yilma, Jennie Ruelas Castillo, James T. Gordy, et al.
Abstract Mycobacterium tuberculosis ( Mtb) is one of the leading infectious causes of death worldwide. There is no available licensed therapeutic vaccine that shortens active tuberculosis (TB) disease drug treatment and prevents relapse, despite the World Health Organization’s ca…
Sadovska D, Nodieva A, Pole I, Ķimsis J, Vīksna A, et al.
… exogenous reinfection are two possible causes of recurrent tuberculosis (TB). However, in some cases, precise cause determination can be challenging. In this study, we used whole genome sequencing to determine pairwise SNV distances and detect differing SNVs in initial and subse…
Nisha Wanichwecharungruang, Weerinth Puyati, Thanyanuch Sanchat
…nth rifampicin-based regimen for drug-susceptible pulmonary tuberculosis. Clinical trials reported serious adverse drug reactions (ADRs) in only 18% of patients, with a low incidence of grade 3 hyperbilirubinemia (3.3%) in the HPMZ group. However, real-world practice at our insti…
U. C. Samudyatha, Prasanna B T Kamath
Background: Gaps in Tuberculosis Preventive Treatment (TPT) cascade among household contacts (HHCs) of Tuberculosis patients are often attributed to the knowledge gaps among the HHCs. Objectives: To examine the factors affecting the uptake of IGRA testing among HHCs of drug-susce…
Jonathan Izudi, Simon Kyazze, Francis Bajunirwe
…ect on the well-being and treatment outcomes of people with tuberculosis (PWTB). Despite its negative effects, TB-related stigma remains underexplored in high-burden TB settings such as Uganda. **OBJECTIVE:** To examine the factors associated with tuberculosis (TB)-related stigm…
Wilber Sabiiti, Emmanuel Musisi, Bariki Mtafya, Peter M. Mbelele, Khalide Azam, et al.
<h3>Background</h3> Tuberculosis (TB) treatment is long and complex. Here we summarise data from EDCTP-funded studies of the Tuberculosis Molecular Bacterial Load Assay (TB-MBLA) as a TB treatment monitoring tool. <h3>Methods</h3> Treatment naïve participants from four Sub-Sahara…
O. Omosebi, Olanrewaju S.O., Adejumo O.A.
…nce, this paper aims to model the outcome of drug-resistant-tuberculosis and drug-susceptible-tuberculosis patients in Oyo state of Nigeria using the logit function of estimating binary logistic regression model vis-à-vis identifying the success of these TB treatments. At baselin…
Deepak Saxena, Devang Raval, Somen Saha, Jignasa Sathwara, Nishad Halkarni, et al.
…sec> <title>BACKGROUND</title> Patients with Drug sensitive tuberculosis (DSTB) often face challenges in adhering to medications. Tuberculosis Monitoring Encouragement Adherence Drive (TMEAD) is a digital pillbox that provides reminders for pill consumption and facilitates the re…