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McDonald AK, Nakkonde D, Kaggwa P, Zalwango S, Joseph A, et al.
…da. We collected data on demographics, TB-related symptoms, HIV status, and disability measured using the World Health Organization Disability Assessment Schedule (WHODAS 2.0). Results Of the 200 participants, the median age was 33.0 years (IQR 26-44.5); 52.5% were male, and 23% …
Cumming BM, Addicott KW, Maruri F, Pillay V, Asmal R, et al.
…ents were severely impaired in comparison to non-TB and non-HIV-infected controls. However, most bioenergetic parameters were not affected by HIV status or glycemic index. Treatment of TB patients restored the % spare respiratory capacity (%SRC) of the circulating lymphocytes to …
Osman M, van Schalkwyk C, Naidoo P, Seddon JA, Dunbar R, et al.
In 2011, the South African HIV treatment eligibility criteria were expanded to allow all tuberculosis (TB) patients lifelong ART. The impact of this change on TB mortality in South Africa is not known. We evaluated mortality in all adults (≥ 15 years old) treated for drug-suscept…
Chabala C, Turkova A, Thomason MJ, Wobudeya E, Hissar S, et al.
…ren aged below 16 years with non-severe TB, with or without HIV infection. The primary efficacy and safety endpoints are TB disease-free survival 72 weeks post randomisation and grade 3 or 4 adverse events. Nested pharmacokinetic studies will evaluate anti-tuberculosis drug conce…
V Shukatka, L Skoklyuk, M Germanovych, A Bogdanov, T Ivanenko, et al.
**BACKGROUND:** Ukraine faces intersecting epidemics of HIV and drug-resistant TB (DR-TB), with high risk of progression from TB infection to active disease. The Support TB Control Efforts in Ukraine project supported the National TB Program's efforts to operationalise World Heal…
Dmytro O. Butov, Tetyanas S Butova
… meningoencephalitis (TM) and human immunodeficiency virus (HIV) co-infection in the intensive phase of treatment. Methods: Fifty-four patients with TB / TM and HIV co-infection were enrolled in this study. Group 1 included 23 patients treated with E and H i/v, while rifampicin a…
Kerkhoff AD, Havlir DV
…rapy hold promise for reducing TB incidence in persons with HIV in high-burden settings. In persons who develop drug-susceptible TB, progress to shorten TB treatment continues to be made with the introduction of new drugs and novel treatment strategies that could allow for treatm…
A.O. Temitayo-Oboh, Ayotunde Sherif Azees, J.O. Amin, A.R. Salam, M.M. Fasiku
…ere 83.2% and 43.7% respectively. TB patients with negative HIV status were about two times more likely to have successful treatment outcomes (OR=1.86, 95%CI=1.20-2.88).
 Conclusion: The TSR and cure rate obtained in this study were below the national targets set by the Worl…
Burusie A, Enquesilassie F, Salazar-Austin N, Addissie A
…), age less than 10 years (aRR = 2.69; 95% CI = 1.56-4.61), HIV infection (aRR = 2.62; 95% CI = 1.50-4.59), and relapsed TB (aRR = 3.19; 95% CI = 1.79-4.71) were independent predictors of unfavorable TB treatment outcomes. When we looked separately at children who had been on TB …
Marissa Russell
…ups. * H56:IC31 (investigational vaccine) * Placebo 900 HIV-negative adults with a diagnosis of drug susceptible pulmonary TB are planned to be included, recruited from TB clinics with established relationships to the trial sites at the start of their TB treatment. 5 study…
Abdulrhman Awadh Alharbi, Ibrahim Muhammad Al-Arej, Abdullatif Suliman Alsayegh, Meshal Ibrahim Zaid Al Owias, Bader Sayah Alanezi
… particularly in low- and middle-income countries and among HIV-positive individuals. TB transmission occurs primarily through inhaling aerosolized droplets from an infected person, leading to potential disease progression. Risk factors for TB include close contact with infected …
Dmytro Butov, Yurii Feshchenko, Mykhailo Kuzhko, Mykola Gumenuik, Yurko Kateryna, et al.
…usceptible pulmonary TB with TB meningoencephalitis(TM) and HIV co-infection in the intensive phase of treatment. <b>Material and Methods:</b> 54 patients with TB/TM and HIV co-infection were enrolled in this study. Group1 included 23 patients with TB/TM and HIV co-infection trea…
Seid MA, Ayalew MB, Muche EA, Gebreyohannes EA, Abegaz TM
…Nations (83%), Tigray (85%) and Afar (86%). Mainly old age, HIV co-infection, retreatment cases and rural residence were the most frequently identified factors associated with poor TB treatment outcome. Conclusion The result of this study revealed that the overall TB treatment su…
Grace Kansiime, Abinet M. Aklilu, Joseph Baruch Baluku, Farah Yasmin, Michael Kanyesigye, et al.
…I in the immediate post-TB diagnosis period in Uganda, a TB/HIV-endemic country in sub-Saharan Africa. Methods We included patients enrolled in an observational cohort study of adults diagnosed with drug-susceptible TB followed longitudinally. Adults (≥18 years) without known kid…
Oladimeji O, Adepoju V, Anyiam FE, San JE, Odugbemi BA, et al.
…rity were male, 980 (59.04%), Human Immunodeficiency Virus (HIV) negative status, 1295 (80.24%), diagnosed with smear, 1141 (73.14%), treated in private not-for-profit (PNFP) hospital, 1097 (66.08%), treated for TB between 2014-2016 (18.96%-19.52%). In multivariate analysis, age>…
Felipe Ridolfi, Gustavo Amorim, Lauren Peetluk, David W. Haas, Cody Staats, et al.
…dictors of TB-ADR included concomitant medication (CM) use, HIV-status, glycated hemoglobin (HbA1c), age, body mass index (BMI), sex, substance use, and TB drug metabolism variables (e.g., NAT2 acetylator profile). Bootstrapped backwards selection was used to develop the models. …
Dereck Tait, MBChB
… immunogenicity profile of escalating doses of AERAS-456 in HIV-negative subjects recently treated for drug-susceptible pulmonary TB will be investigated. The study will be conducted at three sites in South Africa. This study will be the first evaluation of AERAS-456 in subjects…
Edwin Nuwagira, Stellah Mpagama, Conrad Muzoora, Joseph Mugerwa, Mike Ssemusu, et al.
…m are from low and middle income settings. Malnutrition and HIV remain the leading risk factors for TB infection. Despite the advocacy and awareness about TB, post-TB morbidity and disability have been neglected by TB programs in Africa. We have previously showed that HIV-positiv…
Argita D. Salindri
…rs such as pre-existing T2DM, human immunodeficiency virus (HIV), and hepatitis C co-infections on post-TB health has not been assessed. To evaluate the relationship between comorbidities and post-TB treatment health, we conducted three observational studies (two retrospective an…
Rockwood N, Cerrone M, Barber M, Hill AM, Pozniak AL
…n its pharmacokinetic and toxicity profile, particularly in HIV co-infected patients on combined antiretroviral therapy (cART). In this commentary, we evaluate evidence supporting increased global use of rifabutin and highlight key recommendations for action. Discussion Although …
Collins Timire, Mkhokheli Ngwenya, Joconiah Chirenda, John Metcalfe, Katharina Kranzer, et al.
… (6%) DR-TB patients. Thirty-five (72%) DR-TB patients were HIV co-infected. Overall, 80% (95% CI:77-82%) of TB patients and their households experienced catastrophic costs. The major cost drivers pre-TB diagnosis were direct medical costs. Nutritional supplements were the major …
Timire C, Ngwenya M, Chirenda J, Metcalfe JZ, Kranzer K, et al.
… (6%) DR-TB patients. Thirty-five (72%) DR-TB patients were HIV co-infected. Overall, 80% (95% CI: 77-82) of TB patients and their households experienced catastrophic costs. The major cost driver pre-TB diagnosis was direct medical costs. Nutritional supplements were the major co…
Kim Y, Kim SP, Han S
…nly reported in patients with human immunodeficiency virus (HIV). However, a similar reaction to anti-TB therapy can also occur in patients without HIV, especially in patients who have undergone solid organ transplantation. A 65-year-old woman who underwent kidney transplantation…
O. Omosebi, Olanrewaju S.O., Adejumo O.A.
…sociated with DS-TB categorised patients (i.e. Relapse) and HIV status (i.e. Negative). Also, for the DR-TB patients, the results depicted that mortality significantly associated with DR-TB categorised patients (i.e. TAF, Treatment after Loss to Follow Up and New), both HIV statu…
Finlayson H, Lishman J, Palmer M
…s 'rule-in' tests for children with presumed TB living with HIV. Treatment decision algorithms can be used to diagnose TB in symptomatic children in settings with and without access to chest X-rays; bacteriological confirmation should always be attempted. Summary Recent guideline…