Showing 26–50 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
University College, London
…: The objective of the Phase 2B stage is to identify novel regimens of 16 weeks' duration with acceptable safety profile and the greatest potential, based on assessment of quantitative sputum liquid culture and treatment failure/relapse, to progress to investigation of optimal t…
Dr. Banurekha MBBS., MPH
The 4-month daily regimen containing moxifloxacin (2HRZEM 7 / 2HRM7) of ICMR-NIRT was studied in 321 sputum positive pulmonary TB patients in a randomised clinical trial. Of the 321, there were 96% with sputum smear grading of 2+/3+ and 80% with \>2 zone involvement in the chest …
Ju Mi Lee, Jiyun Park, Sang‐Won Choi, Byung Woo Jhun, Su‐Young Kim, et al.
…se (MAC-PD) remain unsatisfactory. Thus, improved treatment regimens for MAC-PD are required. Clofazimine has recently been revisited as an effective drug against mycobacterial infection. We performed a comparison between the standard regimen and an alternative regimen (replacing…
Joseph M. Cicchese
… antibiotic treatment. Importantly, we find that changes to regimens provide greater improvements in granuloma sterilization times for these individuals. We also present a new pharmacodynamic model that incorporates the synergistic and antagonistic interactions associated with co…
J van Ingen, F -Q ter Bruggen, A Lemson, W Hoefsloot
…cure in MAC-PD patients treated with clofazimine-containing regimens at a Dutch tertiary care center. Methods Single-centre retrospective cohort study of adults with macrolide-susceptible MAC-PD who initiated treatment with clofazimine as part of either a standard ethambutol-macr…
J. A. M. Raaijmakers, Mike Marvin Ruth, Jodie A. Schildkraut, Erik van den Hombergh, Rob E. Aarnoutse, et al.
…ls infected with M. avium ATCC 700898 were exposed to these regimens for 21 d. PK profiles were determined at d 0 and d 21. The pharmacodynamic effect was measured by determining bacterial densities at d 0, 3, 7, 14 and 21 for intra- and extracellular fractions. Emergence of macr…
Hélène E. Aschmann, Allan Musinguzi, Jillian L. Kadota, Catherine Namale, Juliet Kakeeto, et al.
…f offered different tuberculosis preventive treatment (TPT) regimens, and under which conditions they would accept treatment. Actionable evidence regarding preference for TPT is needed to inform policy and the development of novel TPT regimens. Methods: Adults engaged in care at …
Shabadi N, Prashanth Kumar NK, Prakash B, Kulkarni P, Narayana Murthy MR
Introduction In the context of changing over from an intermittent treatment regimen to a daily regimen, it becomes crucial to understand the impact of a daily regimen on the treatment process and outcome. It enables health professionals to strengthen strategies, to enhance the qu…
J. A. M. Raaijmakers, Sandra Salillas, Rob E. Aarnoutse, Elin M. Svensson, Lindsey te Brake, et al.
…macodynamics were monitored throughout the experiment. Both regimens led to sustained bacterial killing (both intracellular and extracellular) throughout the experiment. No difference in kill rate was observed between the two therapies. The extracellular kill rate for the 3-drug …
Hua Li, Tong Li, Jun Wang, Qingtao Liang, Yun Zhang, et al.
BACKGROUND: ) lung disease remains far from satisfying. An effective regimen is needed to solve the problem. METHODS: lung disease who received antibiotics regimen at Beijing Chest Hospital Affiliated to Capital Medical University between July 1, 2010, and February 1, 2018. Patie…
Dhondiba Haribhau Bhise
…tum smear conversion in daily versus intermittent treatment regimens in diagnosed cases of new sputum smear-positive pulmonary tuberculosis patients. METHODS This retrospective observational study was carried out in the Department of Respiratory medicine and nodal drug resistance…
Xiaonan Geng, Fan Zhang, Ruichao Liu, Fuzhen Zhang, Ziwen Li, et al.
… and compare the effectiveness of different DR-TB treatment regimens and to assess their safety profiles based on the frequency of adverse events and drug-specific reactions. **METHODS:** We systematically searched PubMed, Web of Science, and Embase for relevant studies publishe…
Muniyandi M, Karikalan N, Velayutham B, Rajsekar K, Padmapriyadarsini C
Globally efforts are underway to shorten the existing 6-month tuberculosis (TB) treatment regimen for drug-sensitive patients, which would be equally effective and safe. At present, there is a lack of evidence on the cost implications of a shorter 4-month TB regimen in India. Thi…
Kort F, Fournier Le Ray L, Chauffour A, Jarlier V, Lounis N, et al.
…nds supervising the treatment of tuberculosis. Intermittent regimens have the potential to simplify the supervision and improve compliance. Our objective was to analyse the sterilising activity of once-weekly regimens based on drugs with a long half-life, bedaquiline and rifapent…
Vijay Kumar, Upinder Kaur, Mohit Bhatia, Jaya Mishra
<bold>Introduction:</bold> Real-world evidence on oral regimens for drug-resistant tuberculosis (DR-TB) is scarce. <bold>Aims and objectives:</bold> To assess culture conversion at 6 months and adverse events (AEs) with oral regimens of DR-TB. <bold>Methods:</bold> A prospective …
Ge Q, Ma Y, Zhang L, Ma L, Zhao C, et al.
…ate, adverse reaction rate, and recurrence rate between two regimens. Multivariate Cox regression model was used to identify the potential risk factors for recurrence after successful treatment with proportional hazards assumptions tested for all variables. Results A total of 381…
Sweeney S, Berry C, Kazounis E, Motta I, Vassall A, et al.
…s (TB) that is resistant to rifampicin (RR-TB) are few, and regimens are often long and poorly tolerated. Following recent evidence from the TB-PRACTECAL trial countries are considering programmatic uptake of 6-month, all-oral treatment regimens. We used a Markov model to estimat…
Musisi E, Wyness A, Eldirdiri S, Dombay E, Mtafya B, et al.
…andard-of-care and experimental anti-tuberculosis treatment regimens on the respiratory microbiome and implications for treatment outcomes. Methods In this retrospective study, we analysed the sputum microbiome of participants with tuberculosis treated with six experimental regim…
Wenhong Zhang, Dr.
This study is a randomized controlled trial among asymptomatic tuberculosis individuals aiming to assess whether the standard treatment duration can be shortened to 17 weeks without increasing the types or doses of anti-tuberculosis medications or 13 weeks with the high-dose rifa…
Alexander Berg, James Clary, Debra Hanna, Eric L. Nuermberger, Anne J. Lenaerts, et al.
…necessitating the development of new and improved treatment regimens. Non-clinical evaluation of candidate drug combinations via the relapsing mouse model (RMM) is an important step in regimen development, through which candidate regimens that provide the greatest decrease in pro…
Malaisamy Muniyandi, Nagarajan Karikalan, Banurekha Velayutham, Kavitha Rajsekar, Chandrasekaran Padmapriyadarsini
Abstract Globally efforts are underway to shorten the existing 6-month tuberculosis (TB) treatment regimen for drug-sensitive patients, which would be equally effective and safe. At present, there is a lack of evidence on the cost implications of a shorter 4-month TB regimen in I…
Rokeya Tasneen, Andrew Garcia, Paul J. Converse, Matthew Zimmerman, Véronique Dartois, et al.
…rine models of tuberculosis were used to test whether novel regimens replacing rifapentine and isoniazid with bedaquiline and another drug would maintain or increase the sterilizing activity of the regimen. In BALB/c mice, replacing rifapentine in the PZM backbone with bedaquilin…
Josephine G R Simanjuntak, Made A K Gandhy, Kynthia Sadha
…y in high- burden regions like Indonesia. Shorter treatment regimens have been proposed to improve outcomes for multidrug- and rifampicin-resistant tuberculosis (MDR/RR-TB). This systematic review and Bayesian network meta-analysis aimed to evaluate the efficacy and safety of the…
Lin YJ, Lin HC, Yang YF, Chen CY, Lu TH, et al.
…logical impact and cost-effectiveness of shorter antibiotic regimens in high tuberculosis (TB) burden regions of Taiwan. Methods This study combined the TB population dynamic model and cost-effectiveness analysis with local data to simulate the disease burdens, effectiveness and …
Fekadu G, Wang Y, You JHS
BACKGROUND: Recent clinical findings reported improvement in the treatment outcomes of highly resistant TB (HDR-TB) with the pretomanid (Pa) based regimen. This study aimed to evaluate the cost-effectiveness of the Pa-based regimen for HDR-TB treatment from the perspective of the…