Showing 26–50 of 200 documents
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Indian Council of Medical Research
Tuberculous meningitis (TBM) is the most lethal form of extra pulmonary tuberculosis. This devastating disease kills almost a third of its sufferers and disables a significant proportion of the survivors. TBM poses one of the most difficult diagnostic and therapeutic challenges i…
Surendra Kumar Sharma, Vishwanath Upadhyay, Alladi Mohan
…12 months after culture conversion45. Suggested antibiotics regimens for adults with MAB-pulmonary disease have been adequately described previously in the guidelines459. Expert consultation should be obtained while treating MAB45. Treatment for clarithromycin-sensitive MAB-pulmo…
Radisic MV, Pujato NR, Bravo PM, Del Grosso RC, Hunter M, et al.
…rom other populations or observational. Rifampin-containing regimens have strong pharmacokinetic interactions with immunosuppressive regimens, with high rates of organ dysfunction and ∼20% mortality. This report describes the results obtained using non-rifampin-containing regimen…
Colette Biro, Corinne Muirhead
…ilities and provider experience facilitate chosen treatment regimens. MABSC infections are difficult to treat due to intrinsic and acquired resistance patterns, limited oral antibiotic options, and medication toxicity.2 Optimal treatment duration is not known and people who do no…
Xueyi Chen, Carlos E Ruiz-Gonzalez, Yuderleys Masias-Leon, Medha Singh, Oscar J Nino-Meza, et al.
…men, and retrospective studies showing that rifabutin-based regimens are effective and well-tolerated, both drugs still need dedicated evaluation in TB meningitis. **METHODS:** Mice were intracranially inoculated with Mycobacterium tuberculosis and treated with rifamycin (rifamp…
Heather Wang, Mohammad Mahdee Sobhanie, Courtney Nichols
…. Breakdown of antibiotic classes used in initial treatment regimens for dNTM-infected patients, along with antibiotics that caused patient intolerances. For each antibiotic class that caused intolerance, average time to develop intolerance listed. Conclusion Treatment of dissemi…
Rizvi I, Malhotra HS, Garg RK, Kumar N, Uniyal R, et al.
…iew summarizes the effects of fluoroquinolone in first line regimens in tuberculous meningitis. Methods A systematic search of literature was performed using PubMed, Cochrane Central Register of Controlled Trials (CENTRAL) and LILACS for articles published till march 2017. We als…
Akhmad Imron, Yulius Hermanto, Timotius Wira Yudha, Ahmad Rizal, Vycke Yunivita Kusumah Dewi, et al.
…erculosis therapy for TBM, focusing on optimizing treatment regimens. **METHODS:** This literature review primarily draws from studies available in the PubMed and Scopus databases on TBM regimens, focusing on publications that evaluate higher doses or novel drug therapies. Key s…
Marcelo Radisic, Natalia Pujato, Pablo M. Bravo, Roxana Del Grosso, Martin Hunter, et al.
…mTOR/calcineurin inhibitors (CNI) led to use of alternative regimens for TB treatment in this group of patients. Results obtained in TB treatment with RFP-free regimens in K/KP TX patients are presented. Methods: Retrospective review of confirmed TB cases in K/KP Tx patients. (Ja…
Tosin Ogunsiakan, Kristen D. Fajgenbaum, Thomas B. Montgomery, Gautam M. Phadke, Kiran Gajurel
INTRODUCTION Mycobacterium kansasii (MK) is an environmental nontubercular mycobacterium (NTM) that can occasionally cause human infections. The incidence of MK infection varies by geographic location, but in general, it is much less prevalent than Mycobacterium avium complex (MA…
Xinxin Zeng, Hao Yao, Aole Li, Fei Wang, Juanjuan Liu, et al.
…ytical cohort. Clinical data, including detailed medication regimens, dosages, treatment durations, and adverse events, were collected. **RESULTS:** Of all included children, about a quarter were diagnosed with extrapulmonary TB. The dosage and duration of PZA often did not alig…
Dario Cattaneo, Agostino Riva, Paola Columpsi, Giuseppe Lapadula, Carlo Fìlice, et al.
…rom Botswana treated with dolutegravir-based antiretroviral regimens. Interestingly, only 53% of the 739 TB/HIV coinfected patients who received rifampicin- and dolutegravir-based regimens received the twice daily dolutegravir dosing suggested by international guidelines (and for…
Trina Sarkar, Niccolò Riccardi, Haresh D Wagh, Zarir Udwadia
Sir, Rifampicin (RIF) is a key drug in the treatment of drug-susceptible tuberculosis;[1] however, RIF associated adverse reactions pose a threat to effective anti-tuberculosis treatment.[2] Thrombocytopenia due to RIF is well known since 1970, is a rare, immunologically mediated…
Shireen Yan Ling Tan, Jamie Bee Xian Tan, Dorothy Hui Lin Ng
…of poor companion antibiotics, such as macrolide-containing regimens without amikacin. Continuous surveillance and research will be vital in addressing this emerging public health threat. Acknowledgement We thank our research coordinator Ms Charlene Suk Teng Cheong, Department of…
Ruth A Howe, Binayak Rimal, Jay Khandelwal, Chandra M Panthi, Gyanu Lamichhane
…ntibiotics, modeled after tuberculosis treatment, but these regimens are limited by toxicity, poor adherence, and low cure rates. Importantly, unlike M. tuberculosis, M. avium is acquired from the environment rather than transmitted between humans, weakening the rationale for mul…
Ruth A Howe, Binayak Rimal, Jay Khandelwal, Chandra Panthi, Gyanu Lamichhane
…ntibiotics, modeled after tuberculosis treatment, but these regimens are limited by toxicity, poor adherence, and low cure rates. Importantly, unlike,is acquired from the environment rather than transmitted between humans, weakening the rationale for multidrug therapy as a strate…
Dhruv Gandhi, Viren Amesur, Aditi Gupta, Minnie Bodhanwala, Ira Shah
A bstract Background: Conventional first-line regimens for pediatric central nervous system tuberculosis (CNS-TB) have been associated with poor clinical outcomes. In view of their bactericidal effect and high penetration rates into the CNS, ethionamide and ofloxacin may improve …
Armine Galstyan, Borisov Se, Michail Sinitsyn, Diana Ivanova, Ludmila Slogodskay
<b>Background:</b> The use of Bedaquiline-containing regimens improves outcomes of treatment, but the safety of bedaquiline (Bdq) in HIV patients is not enough studied. The aim was to analyze the frequency and severity of adverse drug reactions (ADRs) during bedaquiline-containin…
Pranger AD, van der Werf TS, Kosterink JGW, Alffenaar JWC
…ination. Simplified, shorter and preferably less toxic drug regimens are being investigated for pulmonary TB to counteract emergence of drug resistance. Intensified regimens with high-dose anti-TB drugs during the first weeks of treatment are being investigated for TB meningitis …
Nabaneeta Dash, Maura Manion, Sarah L. Silverberg, Ian Kitai
Worsening of clinical, radiologic or laboratory parameters while receiving appropriate antituberculous therapy (ATT) is broadly classified as a “paradoxical reaction” (PR). In this review, we refer to PR as a dysregulated inflammatory response following the institution of appropr…
Dhruv Gandhi, Viren Amesur, Aditi Gupta, Minnie Bodhanwala, Ira Shah
Abstract Background Conventional first-line regimens for pediatric central nervous system tuberculosis (CNS-TB) consisting of isoniazid (H), rifampicin (R), pyrazinamide (Z), and ethambutol (E) have been associated with poor patient outcomes. In view of their bactericidal effect …
Ravindran Chetambath
… chance of noncompliance; hence, shorter and more effective regimens with preserved safety profiles are needed to eliminate TB. Due to highly variable pharmacokinetic properties and a short half-life, suboptimal concentrations have been associated with decreased 2-month sputum cu…
Zachary A. Yetmar
…apolated from nontransplant populations. Typical antibiotic regimens commonly have drug-drug interactions with usual maintenance immunosuppression and carry many potential adverse effects. Third, transplant recipients are at risk for concurrent pathogens, which can complicate NTM…
Olga Adriana Căliman-Sturdza
…iagnostics for cerebrospinal fluid (CSF), refined pediatric regimens, and emerging intensified/adjunctive treatments. Narrative synthesis of current guidelines and peer-reviewed articles (priority on 2019–2025), with an emphasis on pathophysiology, diagnostics, treatment (drug-su…
Lorisna Hardiknastia Damastiwi, Saiful Hidayat, Paulus Stephen Pulung Aditya Nugraha Sembiring
…ry outcome of this study was to analyze the impact of these regimens in decreasing the risk of death and neurological deficit. The articles were collected using the PRISMA diagram, critically appraised using PICO analysis, then the data were analyzed using Review Manager 5.4.1 so…