Showing 26–50 of 200 documents
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Torane VP, Nataraj G, Kanade S, Deshmukh CT
…objective Global TB report 2021 mentions 11 % prevalence of pediatric TB, whereas 5.65% of the cases were reported from India in 2020. India features in the list of TB high burden countries, HIV-TB high burden and MDR-TB high burden countries. The diagnosis of pulmonary tuberculo…
Jhanjhria S, Kashyap B, Gomber S, Gupta N, Hyanki P, et al.
…tations in Mycobacterium tuberculosis strains isolated from pediatric TB patients from a tertiary care hospital. Material and methods A total of 51 pulmonary and extra pulmonary specimens were collected from clinically suspected pediatric TB cases, who were microbiologically conf…
Ravi Bandhu, Sanjeev Kumar, S. Jain, Ganesh Singh, Neelam Gautam
…fampicin resistance linked to poorer outcomes. Conclusions: Pediatric DR-TB predominantly affects older children from socio-economically disadvantaged backgrounds and crowded living conditions, necessitating enhanced diagnostics, individualized treatment, and strengthened support…
Ravi Bandhu, Sanjeev Kumar, Seema Jain, Ganesh Singh, Neelam Gautam
…fampicin resistance linked to poorer outcomes. Conclusions: Pediatric DR-TB predominantly affects older children from socio-economically disadvantaged backgrounds and crowded living conditions, necessitating enhanced diagnostics, individualized treatment, and strengthened support…
Park M, Owles H, Williams A, Williams B, Whittaker E, et al.
…ildhood death and morbidity worldwide. The diagnosis in the pediatric population remains challenging due to the paucibacillary nature of the disease. Intrathoracic lymphadenopathy is one of the most common manifestations of primary disease but is often difficult to sample. A retr…
Schäfer HL, Barker M, Follmann P, Günther A, Hörning A, et al.
…longs time to effective treatment. Data on risk factors for pediatric MDR from low-incidence countries are scarce. Retrospective nationwide case-control study to analyze MDR-pTB cases in Germany between 2010 and 2020 in comparison to a drug-susceptible (DS)-pTB group. We included…
Muhammad Soaib Said, Razia Fatima, O See, Amjad Khan, Mahmood Basil A. Al‐Rawi, et al.
…to multidrug-resistant (MDR) tuberculosis (TB) treatment in pediatric patients. This multicenter retrospective cross-sectional study was conducted in the programmatic management of drug-resistant tuberculosis sites in Khyber Pakhtunkhwa, Pakistan. Basic characteristics, treatment…
Gupta S, Khanna H, Gupta V, Barman NK, Parihar A, et al.
Objective To identify chest X-ray (CXR) characteristic of Pediatric pulmonary drug-resistant tuberculosis (DRTB) in comparison to drug sensitive tuberculosis (DSTB) for early identification and treatment of DRTB. Methods This was a prospective cross-sectional study in which CXR p…
Hannah-Lena Schäfer, Michael Barker, Peter Follmann, Annette Günther, André Hörning, et al.
…longs time to effective treatment. Data on risk factors for pediatric MDR from low-incidence countries are scarce. Retrospective nationwide case–control study to analyze MDR-pTB cases in Germany between 2010 and 2020 in comparison to a drug-susceptible (DS)-pTB group. We included…
Taneja R, Nahata MC, Scarim J, Pande PG, Scarim A, et al.
…temperature or 30°C for several weeks, to support pragmatic pediatric dosing in the field and reduce wastage. METHODS: BDQ tablets were suspended in simple syrup and a sugar-free vehicle. Each 20 mg/mL formulation was stored at room temperature or 30°C for 30 days in amber dispen…
Sasaki T, Svensson EM, Wang X, Wang Y, Hafkin J, et al.
…aracterize the pharmacokinetics of delamanid and DM-6705 in pediatric participants with multidrug-resistant tuberculosis (MDR-TB). Data from participants between the ages of 0.67 and 17 years, enrolled in 2 clinical trials, were utilized for the analysis. The final data set conta…
Yeshiwork Abebaw, Arash Ghodousi, Dawit Hailu Alemayehu, Abaysew Ayele, Gebremedhin Gebremicael, et al.
…curring with multidrug-resistant tuberculosis (MDR-TB) in a pediatric patient. **CASE PRESENTATION:** A 12-year-old HIV-negative female with a previous history of tuberculosis was admitted in August 2021 to Selale University Comprehensive Specialized Hospital in Ethiopia. She wa…
Kim S, Seddon JA, Garcia-Prats AJ, Montepiedra G
…arm, multistage designs may currently not be appropriate in pediatric trials because of the lack of sensitive and specific intermediate outcomes. However, including an arm with an agent to ameliorate toxicity would be efficient. Covariates can be used to stratify randomization, d…
Hoffman CJ, France T, Cram T, Bodmer JL, Sanders JS
…e. We review the difficulties in diagnosis and treatment of pediatric MDR-TB.
K S S, Saldanha PRM, Kushwah S, Prabhu AS
…ntrol. Objectives To know the current practices among local pediatricians regarding management of TB. Materials and methods Field based cross sectional study. All the registered pediatricians who were practicing in Mangalore, (list - local IAP branch) were included in the study. …
Iqbal A, Ashraf M, Rathore AW, Omer MO, Anjum AA, et al.
…cobacterium tuberculosis (MDR-MTB) isolates, collected from pediatric patients. Fractions of Aloe vera and Allium sativum extracts were separated using glass column chromatography, followed by evaluation of cytotoxicity and mutagenicity by tetrazolium salt (3-(4,5-dimethylthiazol…
Munindra Pratap Singh, Pawan Kumar Sharma, Pradeep Upadhyay, Puneet Agrawal, Dinesh Gupta, et al.
…10%) turned reactive for tuberculosis by CBNAAT. None of thepediatric samples was positive for MDR TB. 66% of children completed treatment and 33% weredeclared cured. Conclusion: 42% positivity after CBNAAT testing for tuberculosis infection incollected samples of sputum and gast…
Shruti Kaushal, Sunil Kumar Dhatwalia, Rakesh Yadav, Sumedha Sharma, Pankaj C Vaidya, et al.
The World Health Organization (WHO) recommends Xpert® MTB/RIF (Xpert) and its advanced version, Xpert® MTB/RIF Ultra (Xpert Ultra), as first-line diagnostic tests for detecting pulmonary tuberculosis (PTB) and rifampicin resistance in children suspected of having the di…
Singh V
Childhood tuberculosis does not get the attention it deserves, both in the general child health services and the TB specific services. The difficulty in identification of the organism due to lack of proper sample as well as lower sensitivity of the smear, made it harder to detect…
Princy GS, Jyoti Iravane, Maitrik Bhupendrabhai Dave
Multidrug-resistant or rifampicin-resistant tuberculosis (MDR or RR-TB) resulted in around 150,000 global deaths.The proportion of new TB cases with MDR/RR-TB declined from 4.1% in 2015 to 3.2% in 2023. 7he National Tuberculosis Elimination Program (NTEP) estimates, in India, a s…
He Huang, J Wei, Hongjie Shen, Qiang Tan, J Xue, et al.
to β-lactamase inhibitor combinations was more serious. Regular monitoring the changes of the etiology of respiratory tract infections in ICU Children is particularly important for the prevention and treatment of multidrug-resistant bacterial infections.
I. B. Kulikova, I. А. Vаsilyevа, А. И. Казаков, Н. И. Клевно, С. А. Стерликов, et al.
The objective: to evaluate tuberculosis situation in the Russian Federation among children aged 0-17 years based on the analysis of key epidemiological rates from official statistics for 2023. Subjects and Methods. Information from official statistical surveillance forms was stud…
Fred Monje, Daniel Kadobera, Yakubu Owolabi, Lilian Bulage, Alex Riolexus Ario, et al.
Abstract Background: Childhood tuberculosis (TB) remains a major public health problem in Uganda. Failure to complete TB treatment is associated with development of multi-drug-resistant TB, continued spread of TB, and death. The World Health Organization (WHO) recommends treatmen…
Ingrid Burkhardt, Nunurai Ruswa, Maria Iitana, Hilya Ekandjo, Mareli M Claassens, et al.
**BACKGROUND:** Multidrug-resistant (MDR) and rifampin-resistant (RR) tuberculosis (TB) is challenging the national response to tuberculosis in Namibia. The recent introduction of Xpert MTB/RIF (Cepheid, Sunnyvale, CA) and the use of new and repurposed drugs have the potential to…
Garcia-Prats AJ, Purchase SE, Osman M, Draper HR, Schaaf HS, et al.
This study characterized the pharmacokinetics of novel 100-mg levofloxacin dispersible tablets in 24 children aged n = 109) with MDR-TB receiving adult (250-mg) levofloxacin tablets, using nonlinear mixed-effects modelling. The adult tablets had 41% lower bioavailability than the…