Showing 26–50 of 200 documents
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Duret A, Thorley E, Eni-Olotu A, Sikdar O, Papineni P
…on with HBV or HCV can lead to an increased risk of adverse treatment outcomes, such as drug-induced liver injury (DILI) in patients with active or latent TB. National guidelines recommend routinely screening for HBV/HCV prior to initiating TB treatment. Our objectives were to 1)…
Suman Saurabh, Pankaj Bhardwaj
The WHO consolidated guidelines on tuberculosis: Module 1, covering preventive treatment and an accompanying operational manual have been released in March 2020.[1] The new guidelines integrate the previously separate algorithms for detection of latent TB infection (LTBI) and the…
Kuscu F, Yildirim F, Erturk D, Cabalak M, Komur S, et al.
Background About 10% of individuals with latent tuberculosis infection (LTBI) develop tuberculosis (TB) disease during their lifetime. People living with HIV (PLWH) have a significantly higher risk of developing tuberculosis disease from latent tuberculosis infection (LTBI) compa…
Sana Sharrack, Caroline Zollinger-Read
…ent the case of a 75-year-old male with no risk factors for latent tuberculosis (TB), who was diagnosed with rheumatoid arthritis and appropriately escalated to adalimumab after failing two csDMARDs. His pre-biologic screen revealed a negative IGRA and normal chest X-Ray. He resp…
…on. Currently, there are no comprehensive clinical practice guidelines providing recommendations for the screening, diagnosis, treatment, and prevention of TB in RD patients. To address this issue, the Collaborative Group for TB Prevention and Control in Patients with RD in China…
Andrey S Borisov, MD, MPH, Robert Belknap, MD, Robert Belknap, MD
…al trial. The trial is conducted in patients diagnosed with latent tuberculosis infection (LTBI) who are recommended for treatment. The primary objective is to evaluate adherence to a three-month (12-dose) regimen of weekly rifapentine and isoniazid (3RPT/INH) given by directly o…
Delia Goletti, Seif Al-Abri, Giovanni Battista Migliori, Cecilia S. Lindestam Arlehamn, Pranabashis Haldar, et al.
… bacillus, Mycobacterium tuberculosis. Despite effective TB treatment being available for over 65 years, TB today causes 1.3 million deaths yearly, mostly in low- and middle-income countries. Drug-resistant TB is the leading cause of death owing to antimicrobial resistant disease…
Clare Bristow, Uli Schwab
…an Immunodeficiency Virus (HIV) are at an increased risk of latent Tuberculosis (TB) reactivation. HIV TB concurrent infection increases mortality and reduces patient quality of life. Screening for latent TB allows treatment to commence, preventing reactivation. In accordance wit…
Per Bjorkman, MD, PhD
…cts maternal and child health, can be used to construct new guidelines for management of TB in women of fertile age. This may contribute to reductions in adverse pregnancy outcomes, including maternal and infant deaths. Objective The overall objective of this project is to inves…
Nyanda E Ntinginya, MD, MSc., Ph.D, Nyasatu Chamba, MD., Irene Andia- Biraro, MD., Ph.D., Davis Kibirige, MD, Ph.D.
… expected to rise substantially as DM prevalence increases. Treatment of Latent TB Infection (LTBI) in this population will likely have a significant clinical benefit. Similar to HIV-infected individuals, those with DM might benefit from therapy to prevent the development of TB d…
Sema Aytac
…with the TB patients and determine whether or not they have latent TB infection and treat them and to detect the active cases among the contacts. In the current guidelines, the importance of screening all the contacts of the patients with pulmonary TB and applying a protective tr…
Basu S, Sharma N, Mase S, Sachdeva KS
…enge of effective management to minimise the progression of latent TB infection (LTBI) to TB, thereby interrupting the chain of transmission. Approximately 5%-10% LTBI cases eventually develop TB in their lifetime with the risk being higher in children, people living with HIV/AID…
Eva Maria Guix-Comellas, Professor
…sis in children and young people receiving antituberculosis treatment (non-intervention group); and Phase 2: quasi-experimental, longitudinal, prospective study (intervention group). The results of the two phases will be compared. The study was carried out in the outpatient tube…
Ren B, Bai X, Zhang H, Sun L, Fang L, et al.
…sis (TB), and about 90% of those infected have asymptomatic latent infections. It has been reported that 85-90% of newly diagnosed active TB cases evolve from patients with latent tuberculosis infection (LTBI). In approximately 5-10% of patients, LTBI progresses to active TB duri…
Tulane University
…kely TB) and in age-matched controls grouped by presence of latent TB infection (LTBI), with cfDNA measured serially in time among TB cases receiving antibiotic therapy. We will also validate standard ranges of quantitative cfDNA established for clinical subgroups of children wit…
Bar-Meir M, Pariente G, Romem A, Wiener-Well Y
Objective Official guidelines recommend tuberculosis (TB) screening programmes for all healthcare workers (HCWs), along with offering treatment when latent TB infection (LTBI) is diagnosed. However, adherence to treatment among HCWs is lower compared with non-HCWs. The aim of the…
Richard E. Chaisson, MD, Susan Swindells, MBBS
… At the time the study was designed, the standard course of treatment for TB was 6 to 9 months of isoniazid (INH).This study compared the safety and effectiveness of a 4-week regimen of rifapentine (RPT) plus INH versus a standard 9-month regimen of INH in HIV-infected people who…
Dobler CC, Bosnic-Anticevich S, Armour CL
…was to explore the views of tuberculosis (TB) physicians on treatment of latent TB infection (LTBI), focusing on decision making and communication in clinical practice. 20 Australian TB physicians participated in a semistructured interview in person or over the telephone. Intervi…
O'Connell J, Oguntuase J, McConkey S, de Barra E
…on It is estimated that 24.8% of the world's population has latent TB. The World Health Organization's (WHO) End TB Strategy states that the systematic identification and management of LTBI in groups of people at high risk of reactivation is an essential part of TB elimination in…
Sachin Atre
…o years after diagnosis of the index case.[3] TB preventive treatment (TPT) is recommended for all groups who may have the latent TB infection. These include children below and >5 years of age, adolescents, and adult household contacts. TPT remains a vital component of the active…
David Pride, Maria Gennaro, Michael Lauzardo, Niaz Banaei, Nahed Ismail, et al.
…tb) becomes ill. Therefore two TB-related conditions exist: latent TB infection (LTBI) and TB disease. People with latent TB infection are not ill and do not present TB symptoms or have TB disease. The only sign of TB infection is a positive reaction to the tuberculin skin test …
Bedingfield N, Barss L, Oxlade O, Menzies D, Fisher D
Setting Identification, assessment, and treatment of latent TB infection (LTBI), collectively known as the LTBI cascade of care, is critical for TB prevention. Objective The objective of this research, conducted within the ACT4 trial, was to assess and strengthen the LTBI cascade…
Kampmann B, Seddon JA, Paton J, Nademi Z, Keane D, et al.
…ays (IGRA) to the tuberculin skin test (TST) in its 2006 TB guidelines. Treatment for TB infection was no longer recommended for children who screened TST-positive but IGRA-negative. Objectives We performed a cohort study to evaluate the risk of TB disease in this group. Methods …
Brett K, Dulong C, Severn M
…xtrapulmonary TB). Individuals with TB are categorized into latent TB infection (LTBI) and active TB disease., LTBI refers to an individual whom does not have TB disease and may not possess any symptoms but has the M. tuberculosis infection. Persons with LTBI cannot spread TB inf…
Karishma Saran, Tiziana Masini, Isaac Chikwanha, Gregory Paton, Rosalind Scourse, et al.
…e a subset of 23 key policies in diagnosis, models of care, treatment, prevention, and drug regulation to provide a snapshot of national TB policy adoption and implementation. We examine progress since an analogous 2015 survey of 23 of the same countries. Results At the time of t…