Showing 26–50 of 200 documents
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Beijing Hospital
Background: Drug resistant tuberculosis is a serious public health problem that threatens the health of human life and the development of society and economy. At present, the diagnosis of drug-resistant tuberculosis mainly depends on traditional drug susceptibility test. But it …
Pan Y, Yu Y, Yi Y, Dou X, Lu J, et al.
Background Diabetes mellitus (DM) and drug-resistant tuberculosis (DR-TB) are serious global public health problems. This study aimed to explore the differences in drug resistance between DR-TB patients with and without DM. Risk factors for developing multidrug-resistant tubercul…
Yadav R, Saini A, Mankotia J, Khaneja R, Agarwal P, et al.
Rapid detection of drug resistance in Mycobacterium tuberculosis is important for the successful treatment of tuberculosis. Fluoroquinolone and aminoglycoside resistance detection by molecular methods becomes more complex due to cross resistance among them. Thus, we aimed to dete…
Mogashoa T, Melamu P, Derendinger B, Ley SD, Streicher EM, et al.
The emergence and transmission of multidrug resistant (MDR) and extensively drug resistant (XDR) Mycobacterium tuberculosis (M.tb) strains is a threat to global tuberculosis (TB) control. The early detection of drug resistance is critical for patient management. The aim of this s…
Muhammad Novran Chalik, Alif Fathurrachman, Linda Andriani, Rouly Pola Pasaribu, Sudarto, et al.
…on immunity, there are two types of pulmonary TB infection: drug-sensitive and drug-resistant. Based on ATD sensitization tests, MTb resistance types consist of TB that is monoresistant, polyresistant, multidrug resistance (MDR), pre-extensively drug resistant (Pre-XDR), extensiv…
Christoph Lange, Keertan Dheda, Dumitru Chesov, Anna M. Mandalakas, Zarir Udwadia, et al.
…search and development and in implementation, to reduce the drug-resistant tuberculosis epidemic.1Lange C Dheda K Chesov D Mandalakas AM Udwadia Z Horsburgh Jr, CR Management of drug-resistant tuberculosis.Lancet. 2019; 394: 953-966Summary Full Text Full Text PDF PubMed Scopus (1…
Norbert Ndjeka, Nazir Ismail
Bedaquiline, a novel therapeutic drug, and clofazimine, a re-purposed drug, are front-line therapies recommended by WHO to treat rifampicin-resistant or multidrug-resistant tuberculosis. Both drugs have been in use in South Africa at least 10 years: bedaquiline since 2007 and clo…
Yenew B, Kebede A, Alemu A, Diriba G, Mehammed Z, et al.
Background The emergence of drug-resistant tuberculosis (DR-TB) has been a major obstacle to global tuberculosis control programs, especially in developing countries, including Ethiopia. This study investigated drug resistance patterns and associated mutations of Mycobacterium tu…
Sharma AK, Gupta N, Kala DK, Patni T, Dixit R, et al.
…s and objectives To determine the prevalence and pattern of resistance to second line drugs among multi drug resistant (MDR) tuberculosis patients being treated on category IV regimen. Methodology This study was conducted at Department of Respiratory Medicine, J.L.N. Medical Coll…
Balasundaram Revathi Mani, Usharani Brammacharry, Venkateswari Ramachandra, Suganthi Palavesam, Muthuraj Muthaiah
The emergence of drug-resistant tuberculosis jeopardizes the TB control programme activities globally. Multidrug-resistant TB is defined as tuberculosis strains resistant to at least two first-line drugs, rifampicin (RIF) and isoniazid (INH). Extensively drug-resistant TB refers …
Trương Thiên Phú, Thuy Le, Viet Tran, Tung Thanh Phan
…ground: Tuberculosis (TB) still threatens human beings when drug-resistant tuberculosis (DR-TB), such as rifampicin-resistant TB, isoniazid-resistant TB, multidrug-resistant TB (MDR-TB), pre-extensively drug-resistant TB, and extensively drug-resistant TB increases continuously. …
LaFreniere M, Hussain H, Vachon J
Background Drug-resistant tuberculosis (TB) is a global public health issue. To monitor this in Canada, surveillance systems have been in place for the last 20 years. Objective To describe drug resistance patterns among TB isolates in Canada in 2017 by type of resistance as well …
Chen Yang, Guangchuan Dai, Yicheng Guo, Tianzhen Wang, Weiwei Gao, et al.
**BACKGROUND:** Drug-resistant tuberculosis has emerged as a major public health issue that requires immediate attention. NTS is an innovative method that allows for the direct detection of clinical samples without the need for culture. It could provide more accurate, reliable, a…
Khawbung JL, Nath D, Chakraborty S
… tuberculosis continuously evolved to resist the antagonist drugs. This has led to the outbreak of resistant strain that gave rise to "Multi Drug Resistant-Tuberculosis" and "Extensively Drug Resistant Tuberculosis" that can still be cured with a lower success rate. While the mec…
Nattakarn Preehativong
… health problem in Thailand according to the high burden of drug resistant tuberculosis. The drugs used in the treatment of drug resistant tuberculosis are classified as new drugs or drugs with new indications that need to use with precautions in closely monitoring This article w…
Natalie E. Nieuwenhuizen, Lei Ji
The standard treatment regime for drug-sensitive TB is two months of therapy with rifampicin (RIF), isoniazid (INH), pyrazinamide (PZA), and ethambutol (EMB), followed by four months treatment with RIF and INH (2) Infection with Mtb strains resistant to RIF and INH is termed mult…
Paryani RH, Gupta V, Singh P, Verma M, Sheikh S, et al.
… is high among household contacts (HHCs) of pre-extensively drug resistant (pre-XDR) TB and XDR-TB, data on yield of systematic longitudinal screening are lacking. We aim to describe the yield of systematic longitudinal TB contact tracing among HHCs of patients with pre-XDR-TB an…
Platon Eliseev, Irina Vasilyeva, Anatoly Vinokurov, E. A. Kuznetsov, Kirill Baibekov, et al.
…utations in M. tuberculosis (MTB) associated with delamanid drug resistance in patients with tuberculosis (TB) in Russia. Delamanid is important in treatment of multi- and extensively drug-resistant TB. Reports on delamanid drug resistance are increasing making it necessary to pe…
Garg RK, Rizvi I, Malhotra HS, Uniyal R, Kumar N
Introduction Drug-resistant tuberculous meningitis has been reported worldwide. Isoniazid mono-resistance is the most frequent cause of drug-resistant tuberculous meningitis, a life-threatening disease. Extensive drug-resistant tuberculous meningitis has also been reported in som…
Osei-Wusu S, Amo Omari M, Asante-Poku A, Darko Otchere I, Asare P, et al.
Background Drug resistance surveillance is crucial for tuberculosis (TB) control. Therefore, our goal was to determine the prevalence of second-line anti-TB drug resistance among diverse primary drug-resistant Mycobacterium tuberculosis complex (MTBC) isolates in Ghana. Materials…
Jin C, Wu Y, Chen J, Liu J, Zhang H, et al.
…ence of resistant Mycobacterium tuberculosis (MTB) strains. Drug-resistant TB, including mono-drug-resistant TB, multidrug-resistant TB (MDR-TB), and extensively drug-resistant TB (XDR-TB), presents significant public health challenges. Methods We conducted a systematic literatur…
Kateete DP, Kamulegeya R, Kigozi E, Katabazi FA, Lukoye D, et al.
…g cause of morbidity and mortality in developing countries. Drug resistance, a huge problem in this contagious disease, is driven by point mutations in the Mycobacterium tuberculosis genome however, their frequencies vary geographically and this affects applicability of molecular…
Siddharth G. Chatterjee
Background: India has largest population of drug resistant tuberculosis, the treatment of which is long and full of adverse drug reactions. Despite the ongoing research in clinical and pharmacological aspects, quality of life in drug-resistant tuberculosis remains less explored. …
Hiral Gadhavi, Akansha Goyal, Binita Aring, Summaiya Mullan
The rate of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) has been steadily increasing in developing countries like India. The availability of rapid and reliable methods for the detection of drug resistance to second-line drugs is vital for adeq…
O'Toole RF
…demic has had on the control of tuberculosis (TB) including drug-resistant forms of the disease. Antimicrobial resistance increases the likelihood of worsened outcomes in TB patients including treatment failure and death. Multidrug-resistant (MDR) strains, resistant to first-line…