Showing 26–50 of 200 documents
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Mortimer TD, Weber AM, Pepperell CS
…nd global TB control efforts are increasingly threatened by drug resistance in Mycobacterium tuberculosis . Unlike most bacteria, where lateral gene transfer is an important mechanism of resistance acquisition, resistant M. tuberculosis arises solely by de novo chromosomal mutati…
Prerna Jasmine Kerketta
…s (TB) by 2025.So we need to have high adherence to anti-TB drugs. We conducted this study to know the adherence to second line drugs for drug-resistant TB. It was a prospective-observational study conducted from November 2022 to May 2024. After obtaining informed consent from th…
Ketema Tafess, Timothy Ting-Leung Ng, Hiu Yin Lao, Kenneth Siu Sing Leung, Kingsley King Gee Tam, et al.
…mergence of Mycobacterium tuberculosis strains with complex drug resistance profiles necessitates a rapid and extensive drug susceptibility test for comprehensive guidance of patient treatment. Here, we developed two targeted-sequencing workflows based on Illumina MiSeq and Nanop…
Thi-Kim-Thang Dao, Dao Dinh, Mai-Hien Chuc, Hai‐Anh Ha
…m 448 inpatient TB cases throughout 2022, encompassing both drug-sensitive and drug-resistant forms of TB. Analysis revealed that drug-resistant TB patients incur significantly higher treatment costs compared to those with drug-sensitive TB, with costs escalating further among ol…
Cheng N, Wu S, Luo X, Xu C, Lou Q, et al.
Purpose To investigate the CT features of drug-resistant pulmonary tuberculosis (DR-PTB) and the diagnostic value of CT in DR-PTB diagnosis to provide imaging evidence for the timely detection of drug-resistant Mycobacterium tuberculosis . Materials and methods A total of 1546 ca…
Chen X, He G, Wang S, Lin S, Chen J, et al.
[This corrects the article DOI: 10.3389/fmicb.2019.01741.].
Tong Chen, Tianchi Yang, Xiang Lin, Sijia Wang, Ping Guo-hua, et al.
ObjectiveTo evaluate the levels and patterns of drug resistance in initially treated smear-negative pulmonary tuberculosis (TB) patients in Ningbo, and provide scientific evidence for the prevention and control of drug-resistant TB. MethodsSputum samples of 1 434 initially treate…
Bhagwat A, Deshpande A, Parish T
Drug resistance is an increasing problem for the treatment of tuberculosis. The prevalence of clinical isolates with pre-existing resistance needs to be considered in any drug discovery program. Non-specific mechanisms of resistance such as increased efflux or decreased permeabil…
Juexin Wang, Chan Chen, Huan Fang, Yong Liao, Qiong Lei, et al.
**OBJECTIVE:** The study aimed to understand the drug resistance profile and transmission characteristics of drug-resistant(MTB) in Ganzhou, China, to provide a scientific basis for developing prevention and control strategies. **METHODS:** DNA extracted from re-cultured positiv…
Zhongchen Ma, Tianhao Sun, Xinyu Bai, Xiang Ji, Qian Zhang, et al.
Introduction In recent years, drug-resistant Mycobacterium tuberculosis strains have gradually become widespread. Most drug resistance is related to specific mutations. We investigated M. tuberculosis drug resistance in the Kashgar area, China. Methods The drug-susceptibility tes…
Yi-Ran Han, Tianhao Wang, Wenping Gong, Jianqin Liang, Huiru An
…nical efficacy of thymopentin combined with antituberculous drugs in treating drug-resistant pulmonary TB (PTB).Methods: Relevant studies were retrieved from PubMed, Embase, Cochrane Library, Chinese Biomedical Literature Database, CNKI, and Wanfang Database. STATA software was u…
Elmiawati Latifah, Endang Yuniarti, Rinto Susilo, Hidayah Karuniawati, Nur Azizah, et al.
Drug-resistant tuberculosis (TB) is a public health problem that poses major challenges to patients, health workers, society, and the health care system. This research is a qualitative study to explore the implementation of drug side-effect monitoring and the role of health worke…
Yao L, Wang B, Chen X, Liu Q, Sheng J, et al.
…uate the safety and efficacy of decortication for stage III drug-resistant tuberculous empyema (TE). Methods We analysed all patients with stage III TE who underwent decortication between March 2015 and October 2019 at Wuhan Pulmonary Hospital. The patients were divided into 2 gr…
Bao X, Liang S, Li J, Ye Q, Wu D, et al.
…ssess the prevalence and control effect of tuberculosis and drug-resistant tuberculosis (TB) in Anhui province, and analyze the trends in the changing drug resistance spectrum of Mycobacterium tuberculosis (Mtb) isolated in Anhui province from 2016 to 2022. Methods From 2016 to 2…
Tamilarasu Kadhiravan
Drug-resistant tuberculosis is an important public health problem. 1 Erratic adherence to antituberculosis treatment often results in treatment failure and is widely considered to be the driving force behind the emergence of drug-resistance in previously treated patients."Drugs d…
Giri VP, Giri OP, Pandey PT, Mishra KN, Prasad RS, et al.
Background Drug-resistant tuberculosis is a major public health problem throughout the world and accounts for substantial morbidity and mortality rates in India, too. Early diagnosis is the corner stone of tuberculosis treatment. State-level and cluster-wise variations in drug re…
Hui Cen, Peng Zhang, Yunchao Ling, Guoping Zhao, Guoqing Zhang
Understanding the mechanisms of drug resistance in(MTB) is essential for the rapid detection of resistance and for guiding effective treatment, ultimately contributing to reducing the global burden of tuberculosis (TB). Under anti-TB drugs pressure, MTB continues to accumulate re…
Н. А. Мацегора, S.O. Polyakova
…logical and biochemical disorders in patients with isolated drugs resistant tuberculosis (DRTB) and coinfection of DRTB/HIV/AIDS in the terminal phase, to assess the extent of their linear relationship.Materials and methods. The method of continuous sampling analyzed the histori…
Brigitta Derendinger, Anzaan Dippenaar, Margaretha de Vos, S. Huo, Rencia Alberts, et al.
…ion Bedaquiline (BDQ) is a lifesaving new tuberculosis (TB) drug undergoing global scale-up. Data on resistance emergence in programmatic settings, especially in patients resistant to other drugs with potentially weak background regimens, is scarce. Such individuals are a priorit…
Gupta-Wright A, Fielding K, van Oosterhout JJ, Alufandika M, Grint DJ, et al.
…ak routine virological monitoring has driven increasing HIV drug resistance. We investigated ART failure, drug resistance, and early mortality among patients with HIV admitted to hospital in Malawi. Methods This observational cohort study was nested within the rapid urine-based s…
G.I.A. Okoroiwu, Gloria I. Onokpise
Introduction: The occurrence of multi-drug resistance tuberculosis among tuberculosis patients has raised global public health concern, especially in Nigeria. The increase in the number of cases of resistance tuberculosis despite the effort and need to curb the menace in Nigeria …
Halisyah Hasyim Lubis
Introduction: Drug-resistant tuberculosis (DR TB) is a condition where Mycobacterium tuberculosis is resistant to isoniazid, rifampicin or resistant to isoniazid and rifampin as well as other first-line anti-tuberculosis drugs (OAT). Tuberculosis (TB) is a contagious infectious d…
Xu G, Liu H, Jia X, Wang X, Xu P
…n health. Rifampin (RIF) is an important first-line anti-TB drug, and rifampin resistance (RIF-R) is a key factor in formulating treatment regimen and evaluating the prognosis of TB. Compared with other drugs resistance, the RIF-R mechanism of Mycobacterium tuberculosis (M. tuber…
Dana Auganova, Aygulya Akisheva, Anna Tsepke, Pavel Tarlykov
…osis mortality has risen in comparison with previous years. Drug resistance is another threatening issue when the resistance to antitubercular (anti-TB) drugs makes therapy less effective. Furthermore, drug resistance is often burdened with compensatory mechanisms that overcome f…
Sushil Giri, Kailash Chandra Semwal, Shruti Agarwal, Gautam Singh Bhandari, Amit Kumar, et al.
Acquiring of the resistance to the variant line of the drugs used in drug therapy for M. tuberculosis is becoming a crucial problem for the entire globe. Mutation in cord factor led to the bacterium resistant against antibiotics therapy. These changes drive the chromosomal mutati…