Showing 26–50 of 93 documents
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M K Wijayanto, J Juniastuti, R Yudhawati, D Handayani
…approximately one million cases annually. The prevalence of drug-resistant (DR) TB is also among the highest, with about 7.4% of cases classified as rifampicin-resistant (RR) or multidrug-resistant (MDR) TB. Indonesia is likewise a high-burden country for TB-HIV coinfection. Nati…
Dana Auganova, Sabina Atavliyeva, Aygulya Akisheva, Anna Tsepke, Pavel Tarlykov
… research is to determine the geographical distribution and drug resistance profiles of Mycobacterium tuberculosis lineage 2, which is predominant in Kazakhstan. A total of over 200 clinical isolates of M. tuberculosis complex (MTBC) were collected from regional phthisiopulmonolo…
Morey-León G, Andrade-Molina D, Fernández-Cadena JC, Berná L
…ite of efforts to reduce the disease, increasing antibiotic resistance has contributed to persist in the top 10 causes of death worldwide. In fact, the increased cases of multi (MDR) and extreme drug resistance (XDR) worldwide remains the main challenge for tuberculosis control. …
Jain P, Singh U, Kumar V, Ratnam R, Jain A
…or diagnosis of Mycobacterium tuberculosis and detection of drug resistance among EPTB cases. Methods The EP samples were subjected to CBNAAT (Xpert MTB/RIF, Cepheid, USA) and wherever possible, to LC (MGIT 960, Becton Dickinson, USA) followed sequentially by first line and secon…
Tatiana Minogina, Leonid Lavrenchuk, Diana Vakhrusheva, Sergey Skornyakov
… for rational chemotherapy selection, especially when rapid drug susceptibility results are unavailable. Objectives To define the mutation patterns and frequency associated with resistance to isoniazid, rifampicin, fluoroquinolones and aminoglycosides in Mtb isolated from bone ti…
Pinhata JMW, Brandao AP, Gallo JF, Oliveira RS, Ferrazoli L
We assessed the performance of MTBDRsl for detection of resistance to fluoroquinolones, aminoglycosides/cyclic peptides, and ethambutol compared to BACTEC MGIT 960 by subjecting simultaneously to both tests 385 phenotypically multidrug-resistant-Mycobacterium tuberculosis isolate…
Ángel de Jesús Dzul-Beh, Karlina García‐Sosa, Andrés Humberto Uc‐Cachón, Jorge Bórquez, Luis Loyola, et al.
…ity shown by spathulenol was established as bactericidal on drug-resistant and susceptible strains of M. tuberculosis. Finally, cytotoxic activity on the Vero cell line (CC50 = 95.7 µg/ml) indicated that spathulenol is a selective anti-M. tuberculosis compound, with a selective i…
Namburete E
…ng the genetic diversity of M. tuberculosis strains causing drug-resistant tuberculosis (DR-TB) in high burden TB and low resources countries such as Mozambique is a key factor to TB disease spread control and world TB epidemic control. Whole-genome sequencing (WGS) better descri…
O. A. Zhurilo, А. І. Barbova, L.B. Skokluk, O. V. Chernov
…osis (NDPTB). Critical concentrations of anti-mycobacterial drugs (AMBD): H; R; E; Z; Lfx; Mfx; Am; cm; Lzd; Bdq; Dlm and Cfz were determined using the BACTEC MGIT system. Sequencing of MBT strains was performed on Illumina MiSeq equipment at the laboratory of microbiology and bi…
Gupta M, Ish P, Malhotra N
The recent guidelines on the Programmatic Management of Drug-Resistant Tuberculosis (DR-TB) in India (PMDT) have been released in March 2021 on World TB Day. The new guidelines have considered emerging diagnostic trends including TrueNat, Xpert Mtb/XDR, Next generation sequencing…
S. V. Sklyuev, Е. М. Жукова, N. V. Stavitskaya
The article describes a clinical case of a female patients with the continuous course of tuberculosis (more than 14 years). Despite the ongoing anti-tuberculosis therapy, the use of all possible surgical methods including valvular bronchial blocking, bacterial excretion persisted…
Irina Kostyukova, Anna Vyazovaya, О. А. Пасечник, Igor Mokrousov
Background . The prevalence of multidrug-resistant tuberculosis poses a serious public health problem, hampering the success of tuberculosis control programs around the world. Aim : Evaluation of epidemiological manifestations of tuberculosis and molecular genetic characteristics…
Akinduti Paul Akinniyi, Ajanaku Christiana Oluwatoyin, Oluwaseun Ejilude, Olumuyiwa Emmanuel Olukayode, Ofem Oluchi Gladys, et al.
Pulmonary morbidity caused by the clonally diverse multi-drug resistant Mycobacterium tuberculosis complex (MDR-Mtbc) is alarming due to increasing resistance to available antimicrobials which further exacerbates the disease burden. The constituted chemical compounds (chemotypes)…
Jantarabenjakul W, Supradish Na Ayudhya P, Suntarattiwong P, Thepnarong N, Rotcheewaphan S, et al.
Background The prevalence of drug-resistant tuberculosis (DR-TB) in adults has stabilized in the past decade. Our study aimed to describe the prevalence of DR-TB in Thai children between 2006 and 2021. Materials and methods Children younger than 15 years old who had culture-confi…
Lindiwe Modest Faye, Mojisola Clara Hosu, Ntandazo Dlatu, Vatiswa Henge-Daweti, Teke Apalata
Hearing loss (HL) is a major global health concern, with drug-induced ototoxicity contributing significantly, particularly in patients undergoing treatment for drug-resistant tuberculosis (DR-TB). In South Africa, where both TB and HIV are prevalent, the risk of treatment-related…
Richmond Ronald Gomes
…tuberculosis infection. There are limited documents on multidrugresistant cervical tubercular lymphadenitis, but there is no evidence which may occur in TB endemic regions. Multidrug-resistant tuberculosis (MDR-TB) occurs when strains of Mycobacterium are resistant to the first-l…
Greif G, Coithino C, Bentancor MN, Robello C
…tive tool for the analysis of tuberculosis transmission and drug-resistance. We used WGS to analyze the Mycobacterium tuberculosis evolution from isoniazid monoresistance to MDR/preXDR during a prolonged household outbreak. The outbreak started with a isoniazid resistant strain (…
Faye LM, Hosu MC, Apalata T
This study investigated the characteristics and outcomes of drug-resistant tuberculosis patients in selected rural healthcare facilities in the Eastern Cape, South Africa. A retrospective review of clinical records from 456 patients, covering the period from January 2018 to Decem…
А. I. Gayda, A. V. Abramchenko, M. I. Romanova, T. V. Toichkina, V. S. Burykhin, et al.
… treatment outcomes in patients with multiple/pre-extensive drug resistant (MDR/preXDR) tuberculosis who interrupted treatment at different time points. Subjects and Methods. 800 patients with MDR/preXDR tuberculosis were enrolled in the study, they were from all regions of the R…
Linhares LA, Dos Santos Peixoto A, Correia de Sousa LA, Lucena Laet JP, da Silva Santos AC, et al.
…en causes of death worldwide. The alarming increase in multidrug-resistant and extensively resistant variants (MDR, pre-XDR, and XDR) makes the disease more difficult to treat and control. New drugs that act against MDR/XDR strains are needed for programs to contain this major ep…
E. S. Ovsyankinа, Л. В. Панова, E. A. Krushinskaya, М. А. Багиров
The objective: to evaluate the effectiveness of short-curse chemotherapy regimens for treatment of MDR/pre-XDR tuberculosis in combination with surgery in older children and adolescents. Subjects and Methods. 51 patients with MDR/pre-XDR respiratory tuberculosis aged 13-17 years w…
Introduction. The treatment of patients with recurrent empyema of the pleural cavity associated with bronchial fistula of the main bronchus has been an urgent problem in phthisiosurgery for many decades. There are non-radi-cal methods of treatment using various variants of bron-c…
Podlekareva DN, Folkvardsen DB, Skrahina A, Vassilenko A, Skrahin A, et al.
Background To cure drug-resistant (DR) tuberculosis (TB), the antituberculous treatment should be guided by Mycobacterium tuberculosis drug-susceptibility testing (DST). In this study, we compared conventional DST performed in Minsk, Belarus, a TB DR high-burden country, with ext…
Ismail NA, Omar SV, Moultrie H, Bhyat Z, Conradie F, et al.
…ves outcomes of patients with rifampicin-resistant and multidrug-resistant (MDR) tuberculosis; however, emerging resistance threatens this success. We did a cross-sectional and longitudinal analysis evaluating the epidemiology, genetic basis, and treatment outcomes associated wit…
Natalya Eremeeva, Tatyana Umpeleva, Diana Vakhrusheva, Sergey Skornyakov, Leonid Lavrenchuk
The problem of resistance of <i>Mtb</i> to antibiotics is a global threat to humanity. Along with drug resistance, <i>Mtb</i> can also develop resistance to other biocides (e.g. disinfectants), but this phenomenon is currently not well understood and became the goal of this …