Showing 26–50 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Chen S, Shang Y, Zheng J, Huo F, Xue Y, et al.
Objectives The co-resistance between bedaquiline and clofazimine raises significant concerns, as they are commonly co-administered as core drugs in drug-resistant TB regimens. The present study aimed to monitor drug resistance-associated gene mutations and the phenotypic change i…
Anderson K, Pietersen E, Shepherd BE, Bian A, Dheda K, et al.
…een HIV-positive and HIV-negative South African adults with drug-resistant tuberculosis (DR-TB) and high incidence of acquired second-line drug resistance. Methods We performed a retrospective review of DR-TB patients with serial second-line TB drug susceptibility tests (2008-201…
Rajeev Ranjan, Venkata Siva Reddy Devireddy
Drug resistant tuberculosis is a major public health concern, since the causative agent Mycobacterium tuberculosis is resistant to the most effective drugs against tuberculosis treatment ie., rifampicin and isoniazid. Globally, it accounts 4.6 percent of the patients with tubercu…
Hailemariam TG, Ayele A, Gelanew T, Atnafu A, Brennan M, et al.
…jor global health challenge, particularly due to increasing drug resistance. Beyond the well-characterized mutations, the mechanisms involved in driving resistance appear to be more complex. This study investigated the differential gene expression of Ethiopian drug-resistant Mtb …
Bwire Wilson Bwire, Maurice C Y Mbago, Amina S Msengwa
**BACKGROUND:** The prevalence of tuberculosis (TB) multi-drug resistance is increasing worldwide, including in Tanzania. This trend hinders the attainment of sustainable development goal number three as it increases the number of cases of the disease and treatment costs. Fewer c…
Jaber AAS, Ibrahim B
…nization (WHO) has reported that Yemen has a high burden of drug resistance and a worrying shortage of implemented diagnostic methods and drug treatment regimens. Therefore, in this study, we evaluated the risk factors associated with multidrug-resistant tuberculosis (MDR-TB) and…
Chen X, He G, Wang S, Lin S, Chen J, et al.
…lly feasible tool for timely and comprehensive diagnosis of drug resistance in developed countries. With the increase in the incidence of multidrug-resistant tuberculosis (MDR-TB), second-line anti-TB drugs are gaining importance. However, genetic resistance to second-line anti-T…
Ansarin K, Sahebi L
Background and objectives Drug-resistant tuberculosis (Tb) is a major public health issue across the world. Therefore, it is crucial to determine its pattern in different regions of the world. The aim of this study was to review the prevalence of drug resistant TB in the west and…
Li M, Deng B, Huang Y, Li Q, Han J, et al.
To investigate the status of the drug-resistant tuberculosis (DR-TB) among children in Sichuan, and to find out the risk factors and high-risk population related to drug resistance among children. The clinical data of tuberculosis patients ≤14 years old with culture-confirmed tub…
Nesri Padayatchi, MBChB, PhD
…omparing treatment success of a gene-derived individualized drug-resistant Tuberculosis regimen to a standard Tuberculosis regimen based on South African National Tuberculosis guidelines. When drug resistance is detected by molecular methods such as the Xpert MTB/RIF assay, seco…
Anila Jaleel, Farouk Qamar Malik, Imran Ali Zaidi, Sana Hafeez, Kiran Namoos
…se which is approximately 270 per 100,000. The emergence of drug resistant MTB poses a serious threat to the ongoing efforts to control the disease epidemic. Drug resistance to the first line drugs such as Isoniazid (INH) and Rifampicin (RIF) needs to be investigated. In this res…
Xu P, Li M, Jiang Q, Yang C, Liu X, et al.
Objective Drug resistance is the critical determinant for appropriate tuberculosis (TB) treatment regimens and an important indicator of the local TB burden. We aimed to investigate and compare trends in TB drug resistance in the urban Songjiang District of Shanghai from 2011 to …
Kidenya BR, Mshana SE, Fitzgerald DW, Ocheretina O
Background Drug resistant Tuberculosis (TB) is considered a global public health threat. Whole-genome sequencing (WGS) is a new technology for tuberculosis (TB) diagnostics and is capable of providing rapid drug resistance profiles and genotypes for epidemiologic surveillance. Th…
Wei Wang, Yuxin Gao, Yong Gao, Tuantuan Li, Yan Liu, et al.
**OBJECTIVE:** This study aimed to analyze drug resistance patterns and inpatient medication utilization among drug-resistant tuberculosis (DR-TB) patients in Fuyang City (2021-2023), and to identify factors associated with unsuccessful treatment outcomes in multidrug-resistant t…
Liu D, Huang F, Zhang G, He W, Ou X, et al.
Objectives Phenotypic drug susceptibility testing for prediction of tuberculosis (TB) drug resistance is slow and unreliable, limiting individualized therapy and monitoring of national TB data. Our study evaluated whole-genome sequencing (WGS) for its predictive accuracy, use in …
Sarwer MI, Khan MT, Khurshid S
Introduction Phenotypic drug susceptibility testing is the most common approach to assess drug-resistant isolates; however, molecular methods of drug susceptibility testing are fast, accurate hence, offer less time for transmission during the diagnosis period. As data on the mole…
Liu L, Zhao X, Wu X, Li S, Liu B, et al.
Background The emergence of antimicrobial resistance against Mycobacterium tuberculosis (M. tuberculosis) has become the major concern in global tuberculosis control due to its limited therapy options and high mortality. However, the clinical and molecular characteristics of drug…
Trigos AS, Goudey BW, Bedő J, Conway TC, Faux NG, et al.
The evolution of resistance to one antimicrobial can result in enhanced sensitivity to another, known as "collateral sensitivity." This underexplored phenomenon opens new therapeutic possibilities for patients infected with pathogens unresponsive to classical treatments. Intrinsi…
Eoh H, Liu R, Lim J, Lee JJ, Sell P
…r non-replicating and lacking a stably heritable antibiotic resistance, termed drug tolerance). The formation of drug-tolerant Mtb persisters is associated with TB treatment failure and is thought to be an adaptive strategy for eventual development of permanent genetic mutation-m…
Tao NN, Li YF, Song WM, Liu JY, Zhang QY, et al.
…ve This study was designed to identify the risk factors for drug-resistant tuberculosis (DR-TB) and the association between comorbidity and drug resistance among retreated pulmonary tuberculosis (PTB). Design A retrospective study was conducted among all the 36 monitoring sites i…
Jiandong Yang, Pengwei Lou, Weisheng Zhang, Yanggui Chen, Yaoqin Lu, et al.
…ate the epidemic status and distribution characteristics of drug-resistantin Urumqi. From January 2019 to July 2024, all sputum culture-positivestrains were collected in Urumqi. Using the traditional solid-state proportion method for drug-sensitivity testing, we determined the re…
Robin Varughese John, Hafiz Deshmukh, Sunil Jadhav, Ashish Deshmukh, Shivprasad Kasat, et al.
OBJECTIVE: To study the sensitivity and resistance pattern of multi-drug resistant tuberculosis patients at a tertiary care centre. METHODS: Retrospective study will be conducted at tertiary care centre in Aurangabad from which data of patients will be collected who have register…
Jalil Kardan-Yamchi, Hossein Kazemian, Arash Ghodousi, Daniela María Cirillo, Masoumeh Douraghi, et al.
Aims and objectives: Treatment of patients with drug-resistant tuberculosis is time-consuming and requires expensive drugs with more toxicity. Proper and timely identification of drug-resistant genotypes and determining the minimum inhibitory concentrations (MICs) alongside with …
Wang Z, Sun R, Mu C, Wang C, Zhao H, et al.
…cular characteristics of fluoroquinolone-resistant and multidrug-resistant M. tuberculosis strains using whole-genome sequencing to predict drug resistance in M. tuberculosis in Tianjin, China, which has not been established previously. Methods Twenty-one fluoroquinolone-resistan…
Okumu A, Orwa J, Sitati R, Omondi I, Odhiambo B, et al.
Multidrug-resistant tuberculosis (MDR-TB) is caused by M. tuberculosis ( Mtb ) with resistance to the first-line anti-TB medicines isoniazid (INH) and rifampicin (RIF). In Western Kenya, there is reported low prevalence of drug resistant strains among HIV tuberculosis patients, c…