Showing 26–50 of 200 documents
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Kusum Sharma, Aveg Bhandari, Gowrang Kasaba Manjunath, Mona Rastogi, Aishwarya S. Babu, et al.
…nary sites, potentially influencing clinical outcomes. Poor drug penetration at these sites may cause treatment failure, even in the absence of resistance. Timely access to resistance profiles and lineage information may support more effective, personalized treatment for extrapul…
P. K. Yаblonskiy, B. I. Vishnevskiy, N. S. Solovyova, Vladimir Galkin
The objective: to assess changes in the data on drug resistance of M. tuberculosis for 2015-2021 and compare it with data for 2012-2014. Subjects and Methods. Using continuous sampling, the frequency of drug resistance of Mycobacterium tuberculosis (MTB DR) was studied in isolate…
Kusum Sharma, Megha Sharma, Ritu Shree, Himanshu Joshi, Neeraj Singla, et al.
**PURPOSE:** - The emerging drug resistance in Tuberculous meningitis (TBM) worsens the prognosis and hamper elimination efforts. The need of the hour is a relatively simple, rapid, near point-of-care test that could allow universal drug susceptibility testing, beyond rifampicin …
Pace D, Corvaglia F, Lisi C, Galli L, Chiappini E
…s (EPTB), severe forms of the disease, and the spreading of drug-resistant strains. Describing the characteristics of children with EPTB and those with drug-resistant tuberculosis (DR-TB) and analysing the role of second-line drugs could facilitate the management of these cases. …
N. Neenu, Ketaki Utpat, Unnati Desai, Susvirkar Akshay
…appropriate treatment before the correct diagnosis is made. Drug-resistant cutaneous TB should be suspected in patients with no response to first-line drugs, with clinical deterioration. We are reporting a case of a 15-year-old male with a skin lesion over the right foot who was …
Vishal Wadhwa, Rohini Kelkar, Shibani Ramchandran, Kirti Chadha, Raj Jatale, et al.
…diagnosing extrapulmonary infection and discordance between drug susceptibility reported through culture, Xpert MTB/ RIF, line probe assay require further review. Objectives were to compare positivity rate of Xpert MTB/RIF ULTRA across various sample types; compare drug susceptib…
Kalawadia D, Gandhi D, Dirkhipa TY, Jaiswal A, Shah D, et al.
… months of Delamanid (DLM) based treatment in children with drug-resistant tuberculosis (DR-TB) and determine factors associated with bacteriological conversion. Methods This is a descriptive retrospective study done in children between the age of 6-17 years with DR-TB who receiv…
Animaw Lingerew, Samuel Addis, Adugnaw Atnafu, Zeru Siyoum, Solomie Jebessa Deribessa
Diagnosing extrapulmonary and drug-resistant tuberculosis in children is challenging. Early recognition and treatment improve outcomes and reduce transmission. In this 9-year-old boy, diagnosis of drug-resistant subphrenic TB required a high index of suspicion, appropriate diagno…
T. D. (Tosheva) Rakhmatovna
…esent stage for the treatment of tuberculosis with multiple drug resistance. A clinical example of treatment of a patient with multidrug category 4 resistance, second-line drugs, the use of which made it possible to achieve clinical improvement, cessation of bacterial excretion a…
Tanish Modi, Kusum Sharma, Neeraj Singla, Tina Sood
We aim to study the extensiveness of drug resistance in patients of Tubercular Meningitis (TBM) in our population.
Addo SO, Mensah GI, Mosi L, Abrahams AOD, Addo KK
…es This study sought to determine the genetic diversity and drug resistance profiles of Mycobacterium tuberculosis complex (MTBC) isolates from extrapulmonary tuberculosis (EPTB) patients in Ghana, and their associated immune responses. Methods Spoligotyping was performed on 102 …
Sarika Jain Agrawal, V Mamatha, Somashekar Narasimhaiah
Objectives: Isoniazid (INH) and second-line drug resistance (DR) detection through line probe assay (LPA) takes long in extrapulmonary (EP) specimens because culture growth needs to be obtained to perform deoxyribonucleic acid (DNA) extraction due to the paucibacillary nature of …
Webster Chewe, Abidan Chansa, Patrick Lungu, Namakando Liusha
Extrapulmonary drug resistant tuberculosis (DRTB) is a rare manifestation of disseminated tuberculosis which carries high mortality more so if the central nervous system (CNS) is affected. This paper reviews two cases of extrapulmonary DR-TB, involving two males both aged 32 year…
Webster Chewe, Abidan Chansa, Patrick Lungu, Namakando Liusha
Extrapulmonary drug resistant tuberculosis (DR-TB) is a rare manifestation of disseminated tuberculosis which carries high mortality more so if the central nervous system (CNS) is affected. This paper reviews two cases of extrapulmonary DR-TB, involving two males both aged 32 yea…
Binit Singh, Pankaj Jorwal, Nishant Thakur, Manish Soneja, Naveet Wig, et al.
Abstract Background: Rapid diagnosis of drug-resistant tuberculosis (DR-TB) is very challenging, specifically in extra-pulmonary TB specimens. Methods: Current study was performed on non-sputum specimens. All specimens were subjected on Xpert MTB/RIF Ultra followed by Xpert MTB/X…
Binit Singh, Pankaj Jorwal, Nishant Thakur, Manish Soneja, Naveet Wig, et al.
Abstract Background: Rapid diagnosis of drug-resistant tuberculosis (DR-TB) is very challenging, specifically in extra-pulmonary TB specimens. Methods: Current study was performed on non-sputum specimens. All specimens were subjected on Xpert MTB/RIF Ultra followed by Xpert MTB/X…
Z.I. Pіskur, L.І. Pylypiv, Olga Shvets, M.І. Sakhelashvili, O.P. Kostyk, et al.
…nary tuberculosis (EPTB) taking into account the profile of drug resistance. A retrospective study of medical charts of children with EPTB (n = 47; 1 st group) and pulmonary tuberculosis (PTB) (n = 49; 2 nd group) aged 0-15 for 2013-2020 has been conducted. 2 subgroups with EPTB …
Sharma K, Sharma M, Gupta N, Modi T, Joshi H, et al.
…(TruRif) was evaluated for detection of TBLA and rifampicin resistance and compared with GeneXpert Ultra (Xpert Ultra). Design 100 fine-needle aspirated specimens [50 confirmed by culture/smear/cytology, 20 clinically suspected, and 30 controls], processed in the mycobacteriology…
Lohiya S, Tripathy JP, Sagili K, Khanna V, Kumar R, et al.
Extrapulmonary drug-resistant tuberculosis (DR-EPTB) poses a formidable diagnostic and therapeutic challenge.Besides associated with high morbidity, it is a major financial burden for the patient and the health system. In spite of this, it has often been neglected as it does not …
Qiang Liu, Fen Wang, Haoran Wang, Guanglu Jiang, Adong Shen, et al.
…/MeltPro TB for detecting(MTB) and rifampicin and isoniazid resistance in osteoarticular TB. Pus/tissue samples from suspected osteoarticular TB patients were tested by smear, culture, Xpert, and InnowaveDX; drug-susceptibility testing was conducted on MTB isolates. A comprehensi…
Svetlana Degtyareva, Т. А. Кузнецова, В. Н. Зимина
…ith disseminated pulmonary and extrapulmonary pre-extensive drug resistant tuberculosis, HIV-infection and other severe opportunistic and concomitant infections. Short all-oral regimen has been used for the treatment. This clinical case demonstrates the clinical efficacy of moder…
Ngwira A, Manda S, Karimuribo ED, Kimera SI
…osis (BTB) and human extrapulmonary tuberculosis (EPTB) and drug-resistant tuberculosis (DRTB) can support integrated disease control and monitoring programmes. We employed the recently developed multivariate disease mapping methods to examine whether the diseases exhibited any s…
Xiao Fu, Tongxin Li, Tao Shi, Guobin Deng, Chuanyu Liao, et al.
…uberculosis (MTB) is a threat to human health. However, the drug-resistant Mycobacterium tuberculosis (DR-MTB) is more threat than MTB. In the patients with pulmonary tuberculosis (PTB), the reasons of recurrence are key points for prevention and treatment. Objective: This study …
Alastair Yeoh, Charlotte Brookfield, Stephen Aston, Dennis Wat, Tom Wingfield
…ic overshadowing. We present a case of a patient exposed to drug-resistant TB presenting with a multisystem inflammatory syndrome ultimately diagnosed as disseminated sarcoidosis. Case Report: A 55-year-old Congolese male with type 2 diabetes presented to clinic with a one-month …
Hatolkar SM, Misra RN, Mahato R, Jadhav S
…solates and identify the genomic signatures associated with drug resistance, pathogenesis, and disease transmission. Isolate LJ319 of the Mycobacterium tuberculosis complex (MTC)-Beijing genotype circulating in Maharashtra, India, which was obtained from the cerebrospinal fluid (…