Showing 26–50 of 200 documents
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Haraka F, Kakolwa M, Schumacher SG, Nathavitharana RR, Denkinger CM, et al.
…es (Web of Science). We also searched the WHO International Clinical Trials Registry Platform, ClinicalTrials.gov, and the Pan African Clinical Trials Registry for ongoing trials. Selection criteria We included individual- and cluster-randomized trials, and before-after studies, …
Abraham Y, Assefa DG, Hailemariam T, Gebrie D, Debela DT, et al.
…ns. Methods We searched PubMed/MEDLINE, Cochrane Center for Clinical Trials (CENTRAL), Scopus, ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, US Food and Drug Administration, and Chinese Clinical Trial Registry for primary articles published from 2013 to…
Kolli SS, Kepley AL, Cline A, Feldman SR
… certolizumab pegol and apremilast, using phases III and IV clinical trial data. Expert opinion Even as treatment of psoriasis becomes safer, it is important to recognize both common and uncommon adverse effects of treatment. Common adverse effects are similar across treatment op…
Wickremsinhe MN, Little MO, Carter AS, Sullivan KA, Lyerly AD
…t women's own health needs are addressed, representation in trials of HIV preventives or treatments for comorbidities, and equitable study of newer medications during pregnancy. Methods We employed a keyword search of the International Clinical Trials Registry Platform to identif…
Kate Rich, Ronelle Burger, Andrew Boulle, Deanne Goldberg, Noxolo Gqada, et al.
…B Check. **DESIGN:** The study was a randomised controlled trial with a parallel design. **SETTING:** This study assessed mHealth support to boost TB testing in high-burden Cape Town clinics. **INTERVENTION:** Patients aged 18 or above with a valid mobile phone number that had…
Fan Wu, Suyin Huang, Ming Lei, Zhishan Deng, Qi Wan, et al.
**BACKGROUND:** Clinical trials have shown that glycopyrrolate/formoterol fumarate improves lung function in patients with chronic obstructive pulmonary disease (COPD) caused by tobacco exposure. Although tuberculosis-associated COPD has worse respiratory health outcomes than smo…
World Health Organization
Rapid advances in genomic technologies are transforming clinical research and enabling more precise approaches to disease diagnosis, treatment and prevention, yet their application remains uneven across populations and settings. This analytical report provides a global snapshot o…
Su-Won Lee, Yee Ran Lyu, Si Yeon Kim, Won‐Kyung Yang, Seung‐Hyung Kim, et al.
… a combined formulation containing four herbs, and has been clinically used for bronchitis in South Korea. We conducted a phase II, randomized, double-blind, and placebo-controlled, multicenter trial to evaluate its efficacy and safety. Patients with acute bronchitis or AECB were…
Kitenge M, Phiri B, Pheeha SM, Ogunrombi M, Nyasulu PS
…NE), EMBASE (OVID), Cochrane Central Register of Controlled Trials (CENTRAL), Scopus (Elsevier). We also searched Google Scholar along with trial registries and hand-searched the reference list of identified original research as well as review articles. Conference proceedings of …
Nusrat Shafiq, Ashok Kumar, Vikram Vohra, Gopal Krishan Khuller, Manjula Singh, et al.
…multicentric, investigator-initiated, randomized controlled trial designed to assess the non-inferiority of a 16 week clofazimine-based regimen compared with the standard 24 week regimen for drug-susceptible pulmonary TB (Clinical Trials Registry of India no. CTRI/2019/03/018102)…
Padmapriydarsini C, Mamulwar M, Mohan A, Shanmugam P, Gomathy NS, et al.
…monary tuberculosis (PTB). Methods In a randomized, 8-week, clinical trial, newly diagnosed, culture-positive PTB patients were randomized to standard ATT (HREZ = control arm) or standard ATT plus daily 1000 mg metformin (MET-HREZ = Metformin with Rifampicin [METRIF] arm) for 8 w…
Kohei Fujita, Naoki Fujimoto, Saiki Yoshimura, Shogo Toyama, Takanori Ito, et al.
…t common adverse events (13.8%), followed by fever (10.3%). Clinical trial registration: This retrospective study was registered in the UMIN Clinical Trials Registry (registration No. UMIN000055755). This clinical trial was registered on 6 October 2024 and is publicly available.
Naidoo A, Dooley KE, Naidoo K, Padayatchi N, Yende-Zuma N, et al.
…phase 2b, open-label, non-comparative randomised controlled trial to assess the antiretroviral activity of a fixed-drug, single tablet, combination of bictegravir (BIC) 50 mg/emtricitabine (FTC) 200 mg/tenofovir alafenamide (TAF) 25 mg (Biktarvy). The primary objective is to dete…
Naidoo K, Naidoo A, Abimiku AG, Tiemersma EW, Gebhard A, et al.
…ve of rifampicin (RIF) resistance (RR) status) from several clinical sites across South Africa, Nigeria and Ethiopia will be enrolled over 18-24 months and followed-up for approximately 6 months post-TB treatment completion. Participants will be enrolled into one of two cohorts b…
Mathebula L, Mapahla L, Nurkhametova D, Ziganshina LE, Mazinu M, et al.
… to identify and describe ongoing, planned and completed TB trials conducted in the BRICS countries registered in WHO-International Clinical Trial Registry Platform (WHO-ICTRP); to report selective outcome reporting by comparing primary outcomes in published trials with their pre…
Cattamanchi A, Crowder R, Kityamuwesi A, Kiwanuka N, Lamunu M, et al.
…s We conducted a pragmatic stepped-wedge cluster-randomized trial including all adults treated for drug-susceptible pulmonary TB at 18 health facilities across Uganda over 8 months (1 December 2018-31 July 2019). Facilities were randomized to switch from routine (control period) …
Martinson NA, Nonyane BAS, Genade LP, Berhanu RH, Naidoo P, et al.
… morbidity and mortality. We conducted a cluster-randomized trial of large urban and rural primary healthcare clinics in 3 provinces of South Africa to evaluate whether a novel intervention of targeted universal testing for TB (TUTT) in high-risk groups diagnosed more patients wi…
Zeguang Zheng, Wuzhuang Sun, Jieying Hu, Zhijun Jie, Jin‐Fu Xu, et al.
…ODS: This prospective, randomized, double-blind, controlled clinical trial in 10 centres enrolled patient with AECOPD and a Breathlessness, Cough, and Sputum Scale (BCSS) score of at least 6 points. Eligible patients were randomly assigned (in a 1:1 ratio) to receive either hydro…
Burza S, Mahajan R, Kazmi S, Alexander N, Kumar D, et al.
…ods This is a randomized, open-label, parallel-arm, phase 3 trial conducted within a single hospital in Patna, India. One hundred and fifty patients aged ≥18 years with serologically confirmed HIV and parasitologically confirmed VL were randomly allocated to 1 of 2 treatment arms…
Kang NM, Zhang N, Luo BJ, Wu ED, Shi JQ, et al.
…ntilator-associated adverse events. Registration number for clinical trial Chinese Clinical Trial Registry ChiCTR2000032311, April 21st, 2020.
Wang Chung Kwok, Shung Kay Samuel Chan, Ka Yan Chiang, Jcm Ho
…ECOPD. Methods This is a double‐blind randomized controlled trial. Patients will be randomized in 1:1 ratio to receive oral NAC at 600 mg twice daily or placebo twice daily with standard of care. Partial pressure of oxygen (PaO 2 ), partial pressure of carbon dioxide (PaCO 2 ) an…
Rongrong Kang, Huanqing Liu, Qian Lei, Tingting Li
…aditional statistical models struggle with high-dimensional clinical data, necessitating advanced machine learning (ML) approaches. **OBJECTIVE:** To analyze clinical data from 467 pulmonary TB patients and construct a predictive model using multiple ML algorithms. **METHODS:**…
Xiong L, Chen L, Wang C, Yue J, Li Y, et al.
…d safety, the authors systematically evaluated all relevant trials. Methods The authors searched published trials using the search strategy as (Tanreqing OR "Tanreqing injection") AND ("Tuberculosis" [MeSH] OR Tuberculosis OR TB) in Embase, PubMed, CNKI, VIP, Wanfang Database, CB…
Sahile Z, Perimal-Lewis L, Arbon P, Maeder AJ
…ystematically with evidence-based theory and conducting the trial with strong measurement methods. Methods This study is a single-blind parallel-group design individual randomized control trial. A total of 186 participants (93 per group) will be individually randomized into one o…
Pichanon Mingchay, Kamon Kawkitinarong, Pattama Torvorapanit, Pirapon June Ohata, Gompol Suwanpimolkul
… for presumed PTB. **METHODS:** In a randomized controlled trial at King Chulalongkorn Memorial Hospital, Thailand, 204 adults with presumed PTB and negative Xpert MTB/RIF Ultra results or inadequate sputum production were enrolled between July and October 2024. Participants wer…