Showing 26–50 of 200 documents
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Yadav J, Verma S, Chaudhary D, Jaiwal PK, Jaiwal R
…e being trailed for the development of effective and potent vaccines like mucosal- and epitope-based vaccines, which may replace BCG or boost BCG responses. The use of nanotechnology for diagnosis and treatment of TB is also in the pipeline along with many other vaccines, which a…
Eva Morgun, Jennifer Zhu, Sharan Bobbala, Melissa S. Aguilar, Junzhong Wang, et al.
…ant strains, an efficacious vaccine solution is imperative. Vaccines currently being developed for Mtb utilize protein antigens, which target MHC-restricted conventional T cells, overlooking the potential of Mycobacterium tuberculosis (Mtb) lipid antigens such as mycolic acid (MA…
Nichola R Naylor, Mateusz Hasso-Agopsowicz, Chaelin Kim, Yixuan Ma, Isabel Frost, et al.
…biotic-resistant infections and the potential for bacterial vaccines to mitigate this burden. **METHODS:** We take healthcare system and labour productivity perspectives. Hospital cost-per-case and length-of-stay estimates were calculated through meta-analyses and reviewing publ…
Arpita Batta, Vineeta Singh, Bhartendu Nath Mishra, Tapankumar N. Dhole, Prahlad K. Seth
The aim of this study was to predict promiscuous vaccine candidates against Mycobacterium tuberculosis (MTb) using in silico reverse vaccinology. Antigenic peptides from selected MTb strain LJ319 (4,025 proteins) were analyzed by various immunoinformatics tools; from which 165 ou…
Vikas Jha, Kunal Gharat, Joshua Koli, Ashish Jhangiani, Vrushali Dhamapurkar, et al.
…ne technology aims to accelerate the development of subunit vaccines by identifying specific proteins in a pathogenic bacterial proteome that may be protective antigens. This approach was employed on four extracellular proteins namely Secreted fibronectin-binding protein C antige…
Ayan Mukherjee, Sukhen Samanta, Molla Zakirul Haque, Partha Sarathi Jana, Arun K. Das, et al.
Bovine tuberculosis (bTB) is a severe infectious disease that affects both domesticated and wild animals and has a negative impact on both public health and the global economy. The causative organism of the disease is Mycobacterium bovis and, sporadically, other pathogenic mycoba…
Randeep Guleria, Prof
Prospective, randomized, double-blind, multicentre, placebo-controlled clinical phase IIb trial to evaluate efficacy of RUTI® vaccine in DS- (Drug-Sensitive) and MDR-TB (Multidrug-resistant) patients favourably responding to standard MDR-TB treatment. Time point of vaccination st…
Maltezou HC, Magaziotou I, Tseroni M, Syrigonaki K, Syrogiannopoulos GA, et al.
In 2016 a Βacillus Calmette-Guérin vaccination policy targeting high-risk neonates for tuberculosis before discharge from maternity hospital was adopted in Greece. Vaccination rates were 38.2% in 2019 and 24.7% in 2020. Vaccination coverage varied by risk group (higher for neonat…
Manu Sharma, Sher Afghan, Amit Singh, Iqbal Alam, Meetu Agarwal, et al.
Tuberculosis (TB), caused by(), affects one-third of humanity. Despite the availability of effective drug regimens, complete eradication ofremains challenging due to prolonged treatment duration. Additionally, MDR-TB and co-infection with HIV further exacerbate disease severity. …
Song N, Tan Y, Zhang L, Luo W, Guan Q, et al.
Mycobacterium tuberculosis (M. tb) is emerging as a more serious pathogen due to the increased multidrug-resistant TB and co-infection of human immunodeficiency virus (HIV). The development of an effective and sensitive detection method is urgently needed for bacterial load evalu…
Yari S, Afrough P, Yari F, Ghazanfari Jajin M, Fateh A, et al.
… crucial public health challenge. Therefore, we need new TB vaccines; diagnostic and therapeutic strategies to briskly prevent disease promotion; reduce drug-resistant TB and protect everyone from disease. The study identified various potent membrane and cell wall M. tuberculosis…
da Costa C, Benn CS, Nyirenda T, Mpabalwani E, Grewal HMS, et al.
…ease, is essential to ensure universal access to quality TB vaccines, regardless of their background or personal circumstances.
Ayman Elbehiry, Eman Marzouk, Husam M Edrees, Riyad AlShaqi, Abousree T Ellethy, et al.
…the Xpert MTB/RIF Ultra, BPaLM regimen, and next-generation vaccines such as M72/AS01E represent pivotal progress, their deployment remains uneven. Implementation science, cost-effectiveness analyses, and health equity considerations are vital to scaling up these tools. Moreover,…
Niharika Sharma, Beenu Joshi, Bhawna Sharma, Santosh Kumar, Keshar Kunja Mohanty, et al.
…vel immunological strategies, such as peptide-based/subunit vaccines that can stimulate specific immune responses. In this context, we evaluated the immunogenic potential of two Major Histocompatibility Complex (MHC) Class I/II-restricted peptides from Mycobacterium tuberculosis …
Zhai PY, Chen ZX, Jiang T, Feng J, Zhang B, et al.
This study used a calibrated mathematical model to evaluate age-specific tuberculosis (TB) vaccination strategies, for drug-resistant (DR)-TB management in China. Prioritizing elderly vaccination significantly reduced multidrug-resistant or rifampicin-resistant TB incidence and m…
Strong EJ, Lee S
…ctivating agents, small molecules, and autophagy-activating vaccines may be beneficial in restricting intracellular mycobacterial infection, even with multidrug-resistant strains. This review will examine how mycobacteria evade autophagy and discusses how autophagy could be explo…
Lennin I Garrido-Palazuelos, Haris A Khan, Tooba Ameer, Diego Sarabia-Torres, Omar Guerra-Meza, et al.
Non-typhoidal Salmonella (NTS) remains a major global health concern, aggravated by the emergence of multidrug-resistant strains. This study employed immunoinformatics and structural bioinformatics approaches to design a multi-epitope vaccine targeting the Type IV Secretion Syste…
Williamson ED
In this two-part series of reviews, we have invited experts in their fields to contribute articles on the status of vaccine research and development for emerging pathogens. This topic has been brought into sharp focus in recent years following significant outbreaks of viral disea…
Bourinbaiar AS, Batbold U, Efremenko Y, Sanjagdorj M, Butov D, et al.
Objective Immunotherapy of tuberculosis (TB) to shorten treatment duration represents an unmet medical need. Orally delivered, tableted TB vaccine (V7) containing heat-killed Mycobacterium vaccae (NCTC 11659) has been demonstrated in prior clinical studies to be safe and fast-act…
Chathika K. Weerasuriya, Rebecca C. Harris, Christopher Finn McQuaid, Fiammetta Bozzani, Yunzhou Ruan, et al.
The original article contained errors in the Abstract which have all since been corrected.
Jesús Gonzalo‐Asensio, Nacho Aguiló, Dessislava Marinova, Carlos Martı́n
Tuberculosis (TB) is the biggest killer of humanity. TB has killed more human beings than any other infectious disease in history, with an estimated loss of over a billion lives in the past 200 years (1). Despite effective treatment, in the WHO 2016 there were an estimated 10.4 m…
Chopra H, Mohanta YK, Rauta PR, Ahmed R, Mahanta S, et al.
Tuberculosis (TB), one of the deadliest contagious diseases, is a major concern worldwide. Long-term treatment, a high pill burden, limited compliance, and strict administration schedules are all variables that contribute to the development of MDR and XDR tuberculosis patients. T…
Penny M. Heaton, Jeffrey S. Barrett
…scribes some of the institute's work on candidate drugs and vaccines against tuberculosis, the leading infectious diseases killer in the world. The Bill & Melinda Gates Medical Research Institute (Gates MRI) is a nonprofit biotechnology organization focused on diseases that dispr…
Moreno-Mendieta S, Barrera-Rosales A, Mata-Espinosa D, Barrios-Payán J, Sánchez S, et al.
…vaccine drives the development of new generation multistage vaccines against this disease that can boost BCG-primed immunity. The use of polymeric microparticles for this purpose increases due to their advantages, especially their good safety levels and intrinsic immunostimulant …
Ally Yeketi Ayinla
This project analyses the tuberculosis (TB) epidemic mathematically using compartmental modelling approach. Three models are presented to discuss drug susceptible and multi-drug resistant TB. The first model presented has 4 compartments; susceptible, exposed, infectious and recov…