Modeling the epidemiologic impact of age-targeted vaccination for drug-resistant tuberculosis
Zhai PY, Chen ZX, Jiang T, Feng J, Zhang B, Zang X, Zhao YL, Qin G
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2024-11
Abstract
This study used a calibrated mathematical model to evaluate age-specific tuberculosis (TB) vaccination strategies, for drug-resistant (DR)-TB management in China. Prioritizing elderly vaccination significantly reduced multidrug-resistant or rifampicin-resistant TB incidence and mortality, while avoiding the need for second-line treatment, offering a promising approach to mitigate DR-TB burden by 2050.
MeSH terms
- Humans
- Mycobacterium tuberculosis
- Tuberculosis, Multidrug-Resistant
- Rifampin
- Tuberculosis Vaccines
- Antitubercular Agents
- Vaccination
- Incidence
- Age Factors
- Models, Theoretical
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Middle Aged
- Child
- Child, Preschool
- Infant
- China
- Female
- Male
- Young Adult