Showing 26–50 of 184 documents
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Srinivasa Arer
Background: Childhood tuberculosis is largely underestimated due to diagnostic difficulties and non-specific clinical manifestations, even in many tertiary care hospitals. With increase in coverage of BCG vaccination and improved nutritional status in children, modified clinical …
Hansen SG, Zak DE, Xu G, Ford JC, Marshall EE, et al.
Despite widespread use of the bacille Calmette-Guérin (BCG) vaccine, tuberculosis (TB) remains a leading cause of global mortality from a single infectious agent (Mycobacterium tuberculosis or Mtb). Here, over two independent Mtb challenge studies, we demonstrate that subcutaneou…
White AD, Sibley L, Sarfas C, Morrison A, Gullick J, et al.
A single intradermal vaccination with MTBVAC given to adult rhesus macaques was well tolerated and conferred a significant improvement in outcome following aerosol exposure to M. tuberculosis compared to that provided by a single BCG vaccination. Vaccination with MTBVAC resulted …
Xin Ge, Haoran Wang, Dingpu Liu, Yuhui Dong, Lin Li, et al.
Type II toxin-antitoxin (TA) systems are significantly expanded in thecomplex; however, the functional role of the VapBC40 system in() pathogenesis remains poorly characterized. This study aimed to investigate the role of VapBC40 in mycobacterial virulence and evaluate its potent…
Gloria G. Guerrero, Rogélio Hernández‐Pando
…individuals. There are several new promising candidates for vaccines to replace or boost BCG-induced immunity. Several evidences exist from humans and mice on the role of the trained innate memory of monocytes and NK cells, on the second encounter with the same mycobacterial path…
Nieuwenhuizen NE, Kaufmann SHE
… involves the development of recombinant live mycobacterial vaccines with improved efficacy and safety. The second strategy is to boost BCG with subunit vaccines containing Mtb antigens. This article reviews recombinant BCG strains that have been tested against TB in animal model…
Haoyan Yang, Xinkui Lei, Siyu Chai, Sigen Zhang, Guimin Su, et al.
… highlight the potential of adhesin-inclusive multi-epitope vaccines to elicit both humoral and cellular immunity and demonstrate how computational vaccinology can accelerate the development of targeted interventions against tuberculosis.
Sharifi G, Mousavinejad SA, Moradian K, Ebrahimzadeh K, Samadian M, et al.
Background Brain tuberculoma is a rare manifestation of tuberculosis especially in immunosuppressed patients. The definitive diagnosis may be difficult owing to mimicking brain tumors and the absence of the common presentation. Bacille Calmette-Guérin (BCG) vaccine is used for pr…
Brzezińska S, Zabost A, Borkowska-Tatar D, Klatt M, Goździk J, et al.
According to the World Health Organization (WHO), around 1 million children worldwide are diagnosed with tuberculosis each year. The Bacillus Calmette-Guérin (BCG) vaccine has been used around the world for over 100 years. The complications of the BCG vaccination can occur in abo…
Procianoy GS, Cotrim MW, Cia LO, Behar PRP
Pandemic-related disruptions led to lower Bacille Calmette-Guérin (BCG) vaccine coverage in Brazil. This study highlights a link between reduced vaccinations and increased tuberculosis pulmonary and extrapulmonary cases in infants. Addressing vaccine hesitancy and ensuring health…
Shamaeel, Farzana Shiakh, Ghulam Shabbir Laghari, Yasmeen Memon
Objectives: To determine the frequency of BCG vaccination in children with tuberculous meningitis of age 01 to 12 years at Liaquat University Hospital Hyderabad. Study Design: Cross sectional descriptive study. Setting: Department of Pediatrics, Liaquat University Hospital, Jamsh…
Omair Mazhar, Sher Alam Khan, Muhammad Arsalan Qaisar, Zafar Iqbal Bhatti, Mahwish Akhtar Qureshi, et al.
Aim: The purpose of the study was to govern the incidence of various forms of tuberculosis and the status of BCG vaccination in children. Study design: A Cross-sectional study. Place and Duration of the Study: In the Pediatrics department of Jinnah hospital, Lahore for one-year d…
D'Auria G, Hodzhev Y, Aceves-Sánchez MJ, Moya A, Panaiotov S, et al.
Background Bacillus Calmette-Guérin (BCG) remains the only vaccine to prevent tuberculosis (TB) during childhood, with relatively low to no efficacy against pulmonary TB in adolescents and adults. BCG consists of close to 15 different substrains, where genetic variations among th…
Layton ED, Barman S, Wilburn DB, Yu KKQ, Smith MT, et al.
… of T cells known to be induced by whole cell mycobacterial vaccines, such as BCG, and show that lipid Ag-specific T cells are resident in the lungs, where they may contribute to protective immunity.
Liao TA, Lau A, Sunil J, Hytönen V, Hmama Z
Tuberculosis (TB) is a serious infectious disease and the only available vaccine M. bovis bacillus Calmette-Guérin (BCG) is safe and effective for protection against children's severe TB meningitis and some forms of disseminated TB, but fails to protect against pulmonary TB, whic…
Saeed, N., Al Ansari, H., Al Khawaja, S., Nasser, K., Al Yousef, E.
… from 1990 to 2013,before and after the introduction of new vaccines.Of 1455 reported cases of meningitis during the study period 73.1% were viral and 26.9% were bacterial etiology [tuberculous meningitis 8.3%;Streptococcus pneumoniae 4.9%,Haemophiius influenzoe 3.6% and Neisseri…
Qianfei Liu, Songnian Que, Yixuan Qiu, Mingxing Tang, Shaohua Liu, et al.
…toinfection is a key aspect of the development of effective vaccines and immunotherapies to eradicate tuberculosis. In this review, we delve into the overview of animal models of TB infection and the host's innate and adaptive immune responses toinfection. We discuss howis recogn…
Cha HG, Kim DG, Choi JH
Lymphadenopathy after coronavirus disease 2019 (COVID-19) vaccination is a common side effect that usually resolves within several days to weeks, and only observation is recommended. However, for prolonged lymphadenopathy, other possibilities, including malignancy or other lympho…
Zhang X, Pan L, Zhang P, Wang L, Shen Y, et al.
Background Our previous study revealed the transcriptome atlas of specific cell types in tuberculous meningitis (TBM) model mice injected with the BCG vaccine via scRNA sequencing. However, the activities of miRNAs in TBM at single-cell resolution remain to be explored. Method Ce…
Zhang X, Zhao Z, Wu Q, Wang L, Li L, et al.
Tuberculous meningitis (TBM) is the most severe and deadly manifestation of tuberculosis. Neurological complications are observed in up to 50% of patients affected. Here, attenuated Mycobacterium bovis are injected into the cerebellum of mice, and histopathological images and cul…
Wünsch Filho, V., de Castilho, E. A., Rodrigues, L. C., Huttly, S. R.
Shao MM, Chen QY, Zhang X, Dong SF, Wei RQ, et al.
Tuberculous pleural effusion (TPE) is a prevalent form of extrapulmonary tuberculosis, and immune abnormalities play a crucial role in promoting its development. However, the dynamic changes and regulatory characteristics of immune cells during TPE progression remain incompletely…
Helen McShane
…ce strong cellular immune responses in humans using subunit vaccines. DNA vaccines, recombinant viral vectors and protein/adjuvant combinations all induce both CD4+ and CD8+ T cells, however none of these antigen delivery systems induce high levels of antigen specific T cells, wh…
Stephen Gordon, MD
…uberculosis (TB). Efforts to come up with new and effective vaccines have not been successful. Partially, the lack of suitable disease models and protection correlates hinders the research of new vaccines. Controlled human infection model studies (CHIM) involve administering dise…
Mark F. Cotton, Helena Rabie
…ull Text Full Text PDF PubMed Scopus (35) Google Scholar As vaccines able to prevent pulmonary tuberculosis in children and adults remain elusive and are being actively studied, there is much interest in whether repeat BCG immunisation can fulfil this role. In The Lancet Global H…